Jefferson Medical College Awarded $1.23 Million Grant to Study HIV Clinical
The Center for Research in Medical Education and Health Care
of Jefferson Medical College has been awarded a $1.23 million grant continuation
from the National Institute on Drug Abuse. The grant continuation will study
the clinical outcomes of children born to HIV-infected women. The study
is being conducted in collaboration with researchers in the New York State
Department of Social Services and New York University (NYU)/Bellevue Medical
The center's senior research associate and health services division chief,
Barbara J. Turner, MD, MSEd, will study prenatal care and birth outcomes
for 1,700 New York State (NYS), Medicaid-enrolled, HIV-infected women who
will deliver through August 1996. Dr. Turner also will examine predictors
of maternal-child HIV transmission for these women's infants. Medicaid claims-based
research files and vital statistics records will be used for this analysis.
The research will aim at achieving four basic goals:
1) To evaluate the impact of Medicaid initiatives to improve
prenatal and HIV-related care among HIV-infected, drug-using women;
Similar analyses will be conducted in 240 HIV-infected women and their children
who are followed prospectively at New York University/ Bellevue Medical
Center. The main goal will be to examine the effect of AZT on the risk of
HIV infection among offspring of infected drug-using and non-drug-using
women in the NYS Medicaid cohort and the NYU cohort.
2) To assess the impact of these Medicaid initiatives in increasing the
use of zidovudine (AZT) therapy during pregnancy;
3) To examine the effect of AZT on the risk of HIV infection among offspring
of these HIV-infected women; and
4) To identify major birth defects among offspring of these women and to
evaluate differences in the rates of defects by maternal illicit drug use
and by use of AZT.
"This study unites the power of population-based research using Medicaid
data with specific analyses on a prospectively-followed model," comments
Dr. Turner. "This will extend the understanding of the use of AZT by
pregnant women with a history of illicit drug use and the impact of AZT
on maternal-fetal transmission in actual clinical practice."
Founded in 1969, the Center for Research in Medical Education and Health
Care strives to advance research that provides a greater understanding of
factors affecting the quality and cost of heath care.