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contents
Jefferson Alumni Bulletin
fall 2008
volume 57, number 4
managing editor: Andrea Laine
contributor
Nikki Senecal,
design: JeffGraphics
Bulletin committee
William V. Harrer, MD'62 Chair
Lori Siegel DePersia, MD'81
George P. Valko, MD'86
John H. Moore, Jr., MD GS'85
Robert T. Sataloff, MD'75
Joseph Sokolowski, MD'62
William Clements, MD'58
James Harrop, MD'95
Phillip J. Marone, MD'57, MS'07
Quarterly magazine published
continuously since 1922
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Editor, Alumni Bulletin
Jefferson Medical College of
Thomas Jefferson University
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Philadelphia, PA 19107-4216
215-955-7920
Fax: 215-503-5084
www.jefferson.edu/jmc/alumni/bulletin.cfm
The Jefferson community and supporters are
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above. Postmaster: send address changes
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paid at Philadelphia, PA. ISSN-0021-5821
JG 09-1199
Invasion and
Migration
Angiogenesis
IL-8 leads to
Metastases
Metastases spread
to Lungs
The absence of DACH1 gene allows
higher levels of IL-8 to be secreted,
triggering tumorigenesis
Nucleus
IL-8
DACH1
gene missing
IL-8
Recepter
Blood vessel
Blood vessel
Healthy
breast duct
IL8 attaches to IL8 receptors to activate
breast cancer cellular migration and growth
CANCER
DACH1 Gene Therapy
DACH1 gene vector is injected
into the cell's nucleus, preventing
the IL-8 protein from being secreted.
In healthy cells, DACH1 controls
levels of IL-8. Cells form healthy
breast ducts with the assistance
of these "commandeering" genes
that organize their development.
Nucleus
IL-8
DACH1
gene vector
A
TREATMENT
THOMASJEFFERSONUNIVERSITY
FeatuRes
3
new dean Announcement
6
medical education today
12
moving forward with interprofessional education
DePaRtMents
2
deAn's column
4
findings
Researchers Show Antibody to Breast Cancer-Secreted Protein Blocks Metastasis
Chinese Food Good for Your Heart
14
on cAmpus
18
clAss notes

22
in memoriAm
24
giving
37
By the numBers
pictured on cover (left to right):
James Plumb, MD'74, MPH, Vincent
armenti, MD, PhD'82, William Harrer,
MD'62, Christine Jerpbak, MD, and
Phillip J. Marone, MD'57, Ms'07
09-1199 Fall 08 Bulletin2_CS2.cr4 4
12/1/08 8:55:31 PM