Artificial Pancreas Center
Current Projects
| Evaluation of the GluMetrics GluCath Intravascular Continuous Glucose Monitoring Sensor | |
| Sponsor | GluMetrics Corporation |
| Investigators | Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Lui, MD |
| Description | Animal study to evaluate a continuous intravascular glucose monitoring system for 24 to 48 hours. |
| Evaluation of Animas Continuous Subcutaneous Insulin Infusion Catheter | |
| Sponsor | Animas Corporation (Johnson & Johnson Company) |
| Investigators | Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Lui, MD, Peter McCue, MD |
| Description | Animal study to evaluate a new continuous subcutaneous tissue insulin infusion (CSII) catheters over 5 days of use. |
| Hospital Feasibility 2: A Feasibility Evaluation of the Medtronic Hospital Glucose Management System (HGMS) in Critically Ill Adult Subjects | |
| Sponsor | Medtronic Diabetes |
| Investigators | Jeffrey Joseph, DO, David Gratch, DO, Brian Hipszer, PhD, Murray Cohen, MD, Michael Weinstein, MD |
| Description | The subcutaneous tissue continuous glucose monitoring system being developed by Medtronic is being evaluated in hospitalized patients managed in the ICU. |
| A Pilot Study to Evaluate the Accuracy of Subcutaneous Tissue Interstitial Fluid Continuous Glucose Monitoring Sensors Developed by Medtronic Minimed in Diabetic Volunteers during Mild Hyperglycemia and Hypoglycemia | |
| Sponsor | Medtronic Diabetes |
| Investigators | Jeffrey Joseph, DO, Boris Mraovic, MD, Serge Jabbour, MD, Brian Hipszer, PhD |
| Description | The subcutaneous tissue continuous glucose monitoring system being developed by Medtronic for use in the hospital is being evaluated in diabetic volunteers using a hypoglycemia clamp protocol. |
| Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics | |
| Sponsor | National Institutes of Health NIH/NIDDK (1R21DK081088-01A1) |
| Investigators | Inna Chervoneva, PhD,,, Brian Hipszer, PhD, Jeffrey Joseph, DO, Tanya Atanasovich, PhD |
| Description | Secondary analyses of data collected in clinical studies to develop subject-specific statistical models for population-based analysis of glucose metabolism with application to glucose management of diabetic patients. |
| Evaluation of Continuous Glucose Monitoring Technologies | |
| Sponsor | Teleflex Incorporated |
| Investigators | Jeffrey Joseph, DO, Brian Hipszer, PhD |
| Description | Evaluation of continuous glucose monitoring systems for in-hospital use. |
| Correlation Between Hyperglycemia and Glycosuria in Surgical Patients | |
| Sponsor | Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators | Jeffrey Joseph, DO, Zvi Grunwald, MD, Brian Hipszer, PhD, Inna Chervoneva, PhD, David Gratch, DO, Intekab Ahmed, MD |
| Description | Human clinical trial to correlate changes in a surgical patient’s BG level with the rate of urine production, urine color, urine specific gravity, and the urine glucose concentration. |
| Observational Study of Recurrent Hypoglycemia in Hospitalized Patients using a Continuous Glucose Monitoring System | |
| Sponsor | Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators | Jeffrey Joseph, DO, Zvi Grunwald, MD, Kevin Furlong, DO, Photi Galanis, MD, Nathan Negin, MD, Rachael Sorokin, MD, Brian Hipszer, PhD, Inna Chervoneva, PhD, |
| Description | Two Medtronic CGMS iPro Recorders are used to measure the subcutaneous tissue interstitial fluid glucose concentration every 5 minutes for 3 to 6 days in hospitalized patients at high-risk for hypoglycemia. |
| Observational Study of a Continuous Glucose Monitoring System During Labor, Delivery, and Post-partum | |
| Sponsor | Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators | Michelle Beam, DO,, Jane Huffnagle, DO, Jeffrey Joseph, DO, Suzanne Huffnagle, DO, Brian Hipszer, PhD, Michele Mele, MD, Elia Elia, MD, Wlodzimierz Grodecki, MD |
| Description | Medtronic CGMS iPro Glucose Recorder glucose measurements will be compared to the standard hospital glucose measurement method (fingerstick capillary blood sample and Accu-Chek glucose meter and strip). Glucose sensor accuracy will be evaluated during labor, delivery, and post-partum. |
| Economic Cost of Hypoglycemia | |
| Sponsor | Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators | Jeffrey Joseph, DO, Brian Hipszer, PhD, Boris Mraovic, MD, Rachael Sorokin, MD |
| Description | A nurse survey and an Accu-Chek database analysis will be used to determine the economic cost of diagnosing and treating hypoglycemia at Thomas Jefferson University Hospital (TJUH) |
