233, S. 10th Street
BLSB 904
Philadelphia, PA 19107
(215) 503-4632
(215) 923-1098 fax
BLSB 904
Philadelphia, PA 19107
(215) 503-4632
(215) 923-1098 fax
Most Recent Peer-reviewed Publications
- Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
- Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
- A novel role for the mitochondrial HTRA2/OMI protease in aging
- Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
- Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
Medical School
PhD Temple University School of Medicine - 1991
Keywords
Apoptosis; Cell death; CPP32; Caspases; Pyrin; Nalp3; Inflammation; Innate immunity; Caspase-1; Pyroptosis; Pyroptosome; ASC; AIM; neurodegeneration; omi;