233 S. Tenth Street
Suite 506
Philadelphia, PA 19107
(215) 503-3442
Most Recent Peer-reviewed Publications
- β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
- Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis
- Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s
- PSA regulates androgen receptor expression in prostate cancer cells
- α vβ 6 integrin expression is induced in the POET and Pten pc-/- mouse models of prostatic inflammation and prostatic adenocarcinoma
Education
PhD, Pharmacology, Negri Pharmacological Research Institute, Italy
Expertise & Research Interests
Integrin and Growth Factor Receptor Signaling in Cancer
Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells