Teresa Zimmers, PhD
233 S. Tenth Street
Philadelphia, PA 19107
(215) 503-1077 fax
Most Recent Peer-reviewed Publications
- The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: An analysis of the Survival, Epidemiology, and End Results database
- Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia
- Hedgehog signaling regulates bladder cancer growth and tumorigenicity
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia.
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
PhD, The Johns Hopkins University School of Medicine, Molecular Biology & Genetics - 2001
BS, The Massachusetts Institute of Technology, Biology - 1991
Expertise & Research Interests
The overall aim of my research is to understand the molecular mechanisms regulating organ size. The model system and application we have chosen to study is regulation of skeletal muscle mass in disease. Muscle size is highly plastic and extraordinarily responsive to changes in single genes or pathways. Furthermore, skeletal muscle protein stores and metabolic functions play important and essential roles in the physiologic response to injury and disease. We seek to discover the molecular pathways regulating muscle plasticity in the setting of serious illness. My current funding is directed at defining the roles of three different signaling pathways, IL-6/STAT3, myostatin/ACVR2/SMAD pathway, and SHH/Smo/Gli1 in skeletal muscle wasting in cancer and burn injury. My discovery efforts are aimed at integrating these projects, identifying novel modulators of muscle size and defining the transcriptional cascades involved in muscle growth regulation. The long term goal is to develop targeted interventions for muscle preservation and functional recovery in chronic disease.
Cachexia; regeneration; molecular biology; STAT3; IL-6; myostatin; TGF-beta superfamily; liver regeneration; muscle atrophy; microarray; C2C12 cells; primary cultures; translational research; cancer; oncology; burn injury; muscle wasting; ACVR2B; cytokines; inflammation; cachexia phenotyping; integrative physiology; SHH; Gli1; SMO