Paul F. Bray, MD
Director, Hematology Division
The Cardeza Foundation faculty is dedicated to hematologic research, education and clinical care. Physician members of the foundation comprise the Division of Hematology in the Department and are actively involved in inpatient and outpatient training of residents and fellows.
The elective for medical residents is designed to develop competence in evaluating and managing hematologic problems. It also aims to provide an understanding of the pathophysiologic basis of hematologic problems, and to provide an understanding of the pathophysiologic basis of hematologic disorders. Medical residents participate in the care of inpatients on the hematology service and in hematologic consultations. Outpatient experience in hematology is also available. During the rotation, residents learn to perform and interpret bone marrow aspirations and biopsies.
In addition to Hematology Grand Rounds and research seminar, there are two weekly clinical conferences primarily for residents and fellows.
Clinical research and laboratory research are performed under the guidance of a member of the faculty of the Cardeza foundation or the Division of Medical Oncology. In addition, laboratory research is available under the guidance of several members of the Kimmel Cancer Institute.
Current active research areas in the division include:
- The role of human endothelial cells in hemostasis.
- The regulatory role of matrix in angiogenesis and endothelial cell differentiation.
- The role of extracellular matrix-smooth muscle cell interactions in vascular disease.
- The mechanisms of action of lupus anticoagulants and their relationship to thrombosis.
- Role of proteoglycan interactions with cytokines and extracellular matrix proteins in hematopoiesis, hematopoietic cell function and uterine decidual function; structure/function relationships and regulation of gene expression of proteoglycans in these cells.
- The cellular and developmental expression of thrombopoietin.
- The mechanisms of growth and maturation of mega-karyocytes and related cells.
- The mechanisms of action of erythropoietin in red-cell production and the factors modulating erthropoietin production at the gene level.
- The mechanism of hypoxia-induced gene expression.
- The effect of abnormal hemoglobins and of blood-group antigens on the structure and function of the red cell membrane.
705 Curtis Building
1015 Walnut Street
Philadelphia, PA 19107
We participate in the National Residency Match Program and utilize the Electronic Residency Application Service (ERAS).
- Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
- Neuropathy, neuropathic pain, and sickle cell disease
- Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms
- Population level survival of patients with chronic myelocytic leukemia in Germany compared to the US in the early 21st century
- 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity