Bluemle Life Sciences Building, Room 530
Philadelphia, PA 19107
(215) 503-8917
(215) 923-9248 fax
Most Recent Peer-reviewed Publications
- Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model
- B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact
- Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice
- Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice
- Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment
Medical School
BS, City College of New York, Biology - 1973
MS, Tulane University, Parasitology
- 1977
PhD, University of Pennsylvania, Parasitology
- 1983
Fellowship
University of Pennsylvania (1983-1984)
University of Wisconsin (1984-1987)
Expertise and Research Interests
Role of eosinophils, neutrophils and macrophages in innate and adaptive immunity to nematode infections. The goal of these studies is to define at a molecular level the mechanisms used by these cells, from both humans and mice, to kill parasites and to identify the immune evasion mechanisms used by the parasites
Vaccine development against parasitic helminths. Multivalent vaccines are being developed against Onchocerca volvulus, the causative agent of river blindness, and against Stongyloides stercoralis. The basis of the vaccines will the combination of recombinant antigens with adjuvants capable of inducing specific types of immune responses.