0B68 Zhou, Hongxia - Jefferson Medical College - Thomas Jefferson University
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Hongxia Zhou, PhD

Contact Dr. Zhou

1020 Locust Street
Jefferson Alumni Hall, Suite 508
Philadelphia, PA 19107

(215) 503-1037

Most Recent Peer-reviewed Publications

  1. Reactive astrocytes secrete lcn2 to promote neuron death
  2. Pathogenic mutation in VPS35 impairs its protection aga 1C6D inst MPP+ cytotoxicity
  3. XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats
  4. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
  5. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
  6. Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
  7. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
  8. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
  9. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
  10. Sustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
  11. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
  12. Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS
  13. Developing tTA transgenic rats for inducible and reversible gene expression
  14. A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem
  15. A construct with fluorescent indicators for conditional expression of miRNA
  16. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
  17. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice
  18. Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo
  19. Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes
  20. Transgenic RNAi: Accelerating and expanding reverse genetics in mammals
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