Department of Medical Oncology
S. Onder Alpdogan, MD *
Atrayee Basu Mallick, MD
Avnish Bhatia, MD
Christina Brus, MD
Andrew E. Chapman, DO, FACP
Elena Gitelson, MD, PhD *
Joanne E. Filicko-O'Hara, MD *
Neal Flomenberg, MD *
Michael J. Ramirez
Lewis J. Rose, MD, FACP
Allison Zibelli, MD, FACP
*Practice Focus: Hematologic Malignancies
For further information contact:
Thomas Jefferson University Hospital
Every year in the United States, more than 8,000 people learn they have this disease. Hodgkin lymphoma is most common among teens and adults aged 15 to 35 years and adults aged 55 years and older. Risk factors include certain viruses (Epstein-Barr (EBV) or human immunodeficiency virus (HIV), weakened immune system (such as an inherited condition or from certain drugs used after an organ transplant), and/or a family history of any type of lymphoma.
A cancer of the immune system that is marked by the presence of a type of cell called the Reed-Sternberg cell. The two major types of Hodgkin lymphoma are classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Symptoms include the painless enlargement of lymph nodes, spleen, or other immune tissue. Other symptoms include fever, weight loss, fatigue, or night sweats. Also called Hodgkin disease.
Stage I: The lymphoma cells are in one lymph node group (such as in the neck or underarm). Or, if the lymphoma cells are not in the lymph nodes, they are in only one part of a tissue or an organ (such as the lung).
Stage II: The lymphoma cells are in at least two lymph node groups on the same side of (either above or below) the diaphragm. Or, the lymphoma cells are in one part of a tissue or an organ and the lymph nodes near that organ (on the same side of the diaphragm). There may be lymphoma cells in other lymph node groups on the same side of the diaphragm.
Stage III: The lymphoma cells are in lymph nodes above and below the diaphragm. Lymphoma also may be found in one part of a tissue or an organ (such as the liver, lung, or bone) near these lymph node groups. It may also be found in the spleen.
Stage IV: Lymphoma cells are found in several parts of one or more organs or tissues. Or, the lymphoma is in an organ (such as the liver, lung, or bone) and in distant lymph nodes.
People with Hodgkin lymphoma may be treated with chemotherapy, radiation therapy, or both.
Reference: National Cancer Institute. http://www.cancer.gov/cancertopics/types/hodgkin