S. Onder Alpdogan, MD

Contact Dr. Alpdogan

925 Chestnut Street
Suite 320A
Philadelphia, PA 19107

(215) 955-8874

Medical School
Hacettepe University, Ankara, Turkey - 1983

Residency
Haseki State University
Marmara University Hospital

Fellowship
Memorial Sloan-Kettering Cancer Center, NY
Yale-New Haven Hospital , New Haven, CT

Board Certification

Hospital Appointment
Thomas Jefferson University Hospital
Methodist Hospital Division of Thomas Jefferson University Hospital

Hospital Appointment
Active Medical Staff

University Appointment
Assistant Professor of Medical Oncology

Research and Clinical Interests
Medical Oncology, Hematology-Oncology, Bone Marrow Transplant, Hematologic Malignancies, Leukemia, Lymphoma

Publications

Most recent Peer-reviewed Publications

1. Interleukin-15 administration increases graft-versus-tumor activity in recipients of haploidentical hematopoietic SCT
2. Double Haploidentical Hematopoietic Stem Cell Transplantation Results in Successful Engraftment of Bone Marrow from Both Donors without Graft-versus-Host or Graft-versus-Graft Effects
3. Immune tolerance and transplantation
4. Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation
5. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease
6. Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation
7. STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease
8. Rapidly proliferating CD44hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation
9. Organ-derived dendritic cells have differential effects on alloreactive T cells
10. IFN-γ and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease
11. Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
12. Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stein cell transplantation
13. Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation
14. DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation
15. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
16. Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells
17. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
18. Absence of β7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
19. CCR2 is required for CD8-induced graft-versus-host disease
20. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation

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