Senthamil R Selvan, M.Sc., M.Phil., Ph.D

Contact Dr. Selvin

1015 Walnut Street
Suite 1008, College Building
Philadelphia, PA 19107

(215) 503-1326
(215) 923-0797 fax

Education
1974-77 BSc Presidency College, Madras University, Madras, INDIA (Major: Zoology; Ancillary: Chemistry and Geology)
1977-79 MSc Madras University, Madras, INDIA (Special Zoology; Research Project in Parasitology)
1980-83 MPhil Jawaharlal Nehru University, New Delhi, INDIA (Life Sciences-Specialization in Cancer; MPhil Thesis: Chemoprevention of carcinogen-induced changes in ovary)
1983-88 PhD Jawaharlal Nehru University, New Delhi, INDIA (Doctoral Thesis Subject: Immunotoxicology)

Post-graduate Training and Fellowship Appointments:
1988-89 Post-Doctoral Fellow, Virginia Tech, Blacksburg, VA
1989-95 Research Associate, Duke University Medical Center, Durham, NC

University Appointment
Research Associate Professor
Scientific Director, Melanoma Immunotherapy Program

Translational Research Interests
Cancer Immunology and Immunotherapy: Cancer vaccine, and Dendritic cell and NK Cell-based therapy; Immune-monitoring; Tumor-specific antigens recognized by T cells; Tumor-escape mechanisms; GLP/GMP-Cell-based therapeutic product manufacturing and FDA regulations; Animal models

Publications

Most recent Peer-reviewed Publications

1. Expression of IL-8 gene in human monocytes and lymphocytes: Differential regulation by TNF and IL-1
2. Lack of evidence for MHC-unrestricted (atypical) recognition of mucin by mucinous pancreatic tumour-reactive T-cells
3. Spontaneous activation of endothelial cells: A central role for endogenous IL-1α
4. Complement-induced expression of chemokine genes in endothelium: Regulation by IL-1-dependent and -independent mechanisms
5. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
6. Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1
7. Fenretinide: Induction of apoptosis and endogenous transforming growth factor β in PC-3 prostate cancer cells
8. Heparan sulfate in immune responses
9. Expression of multiple chemokine genes by a human mast cell leukemia
10. Influence of arecoline on immune system: III. Suppression of B cell-mediated immune response in mice after short-term exposure
11. Growth modulatory effects of some 6-methylenic steroids on human and hamster pancreatic adenocarcinoma cells in vitro
12. Influence of arecoline on immune system: II. Suppression of thymus-dependent immune responses and parameter of non-specific resistance after short-term exposure
13. Characterization of T lymphocyte clones isolated from BCNU-cured LSA mice
14. Role of IL-2, IL-4 and IL-6 in the growth and differentiation of tumor-specific CD4+ T helper and CD8+ T cytotoxic cells
15. Aldicarb treatment inhibits the stimulatory activity of macrophages without affecting the T-cell responses in the syngeneic mixed lymphocyte reaction
16. Aldicarb suppresses macrophage but not natural killer (NK) cell-mediated cytotoxicity of tumor cells
17. Influence of arecoline on immune system: I. Short term effects on general parameters and on the adrenal and lymphoid organs
18. Inhibitory action of Piper betle on the initiation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rats
19. Influence of butylated hydroxyanisole on oocyte depletion induced by 7,12-dimethylbenz(a)anthracene in mice

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