Dr. McKenzie Steven McKenzie, M.D., Ph.D.

Contact Dr. McKenzie

1015 Walnut Street
Suite 409
Philadelphia, PA 19107

(215) 955-3900
(215) 923-3836 fax

Research and Clinical Interests
Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.

Publications

Most recent Peer-reviewed Publications

  1. The clot thickens (or not)
  2. Thrombopoietin following transfusion of platelets in preterm neonates
  3. The yin and yang of Fcγ receptors in ITP
  4. Heparin-induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly
  5. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles
  6. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model
  7. Platelet FcγRIIA binds and internalizes IgG-containing complexes
  8. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcγ receptor IIa-transgenic mice
  9. PF4/heparin complexes are T cell-dependent antigens
  10. A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcγRIIA transgenic mice
  11. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
  12. Heparin-induced thrombocytopenia and other immune thrombocytopenias: Lessons from mouse models
  13. Short-Term Use of Umbilical Artery Catheters May Not Be Associated with Increased Risk for Thrombosis
  14. Mechanisms of Action of Therapeutics in Idiopathic Thrombocytopenic Purpura
  15. Platelet count and sepsis in very low birth weight neonates: Is there an organism-specific response?
  16. Mechanisms of action of IVIg: physiology of Fc receptors.
  17. Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential
  18. Thrombopoietin in preterm infants: Gestational age-dependent response
  19. Humanized mouse models of FcR clearance in immune platelet disorders
  20. Insights from mouse models of heparin-induced thrombocytopenia and thrombosis

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