Division of Pulmonary & Critical Care
Research Overview
Examples of Recent or Ongoing Research Activities:
Asthma, Airways Disease, & Airway Hyperreactivity
Clinical and In Vivo Projects
- Safety of regularly used beta2-agonists
- Protective mechanisms controlling acute airway reactions
- Significance of late phase reactions in abnormal airway reactivity
- Epidemiology of airway hyperreactivity
- Leukotriene antagonists in the treatment of airways disease
- Inhaled corticosteroids in the treatment of airway disease
Basic and In Vitro Projects
- Role of inflammatory cells recruited to the lung in producing lung injury
- Function of ciliated respiratory epithelium and response to environmental and inflammatory stressors; epithelium in airway remodeling.
- Eosinophil-fibroblast interactions and collagen gene expression
- Molecular biology of beta-adrenergic receptor - GTP-binding protein interaction
- Mechanics of inflammatory cell recruitment to the lung
- Molecular mechanisms of programmed cell death in eosinophils
- Cytokine networking in allergic asthma
Mechanisms of Acute Lung Injury &
the Adult Respiratory Distress Syndrome (ARDS)
Clinical and In Vivo Projects
- Physiology of ARDS
- Pharmacological and ventilator strategies in ARDS
- Predictors of outcome
Basic and in Vitro Projects
- Cytokine networking in ARDS
Tobacco Research & Treatment
Other Research Activities
Sarcoidosis
- Predictors of relapse in sarcoidosis
- Noncaseating granuloma - decision analysis and sarcoidosis
Epithelial Biology
- Pathophysiology of ciliary function
- Cloning of structural proteins in cilia
Publications (Top 5)
- Norepinephrine or dopamine for septic shock: Systematic review of randomized clinical trials
- Guest Editorial
- Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma
- What intensivists need to know about hemophagocytic syndrome: An underrecognized cause of death in adult intensive care units
- Review for hospitalists: acute pulmonary embolism.
