Joseph Cheung, M.D.
Associate Professor

Contact Dr. Cheung

833 Chestnut Street
Suite 700
Philadelphia, PA 19107

(215) 503-6830
(215) 503-4099 fax

Medical School
M.D., Duke University School of Medicine
Ph.D., Pennsylvania State University

Residency
Duke University Medical Center, Durham, NC

Fellowship
Massachusetts General Hospital, Boston, MA

Board Certification
American Board of Internal Medicine; American Board of Internal Medicine-Nephrology

University Appointment
Capizzi Professor of Medicine

Research and Clinical Interests
Calcium and Heart Failure; Regulation of sodium-calcium exchanger by phospholemman; TRP channels in erythropoiesis; Acute Kidney Injury

Publications

Most Recent Peer-reviewed Publications

1. Induced overexpression of Na+/Ca2+ exchanger transgene: Altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration
2. Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): Roles for PACAP in anxiety-like behavior
3. Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain
4. TRPC3 activation by erythropoietin is modulated by TRPC6.
5. Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): Roles for PACAP in anxiety-like behavior
6. Regulation of cardiac myocyte contractility by phospholemman: Na +/Ca2+ exchange versus Na+-K+-ATPase
7. The Blimp-1 gene regulatory region directs EGFP expression in multiple hematopoietic lineages and testis in mice
8. Regulation of cardiac contractility: High time for FXYD
9. Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1
10. Regulation of cardiac Na+/Ca2+ exchanger by phospholemman
11. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: Duplication, conversion, and the birth of new genes
12. Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: Role of Na+/Ca2+ exchange
13. Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na+/Ca2+ exchanger
14. Frequency division multiplexed multichannel high-speed fluorescence confocal microscope
15. Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion
16. Regulation of the transient receptor potential channel TRPM2 by the Ca 2+ sensor calmodulin
17. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage
18. Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger: Role of phosphorylation
19. Phospholemman overexpression inhibits Na+-K+-ATPase in adult rat cardiac myocytes: Relevance to decreased Na+ pump activity in postinfarction myocytes
20. 3D method via time and spatially multiplexed confocal microscope

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