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Medical School
Louisiana State University, Shreveport, LA
Residency
The Johns Hopkins Hospital, Baltimore, M.D.
Fellowship
The Johns Hopkins Hospital, Baltimore, M.D.
Certifications
American Board of Internal Medicine, Subspecialty in Cardiovascular Diseases
University Appointment
Magee Professor of Medicine (with Tenure) 2002
Research and Clinical Interests
Our laboratory has focused for over two decades on the cellular signaling mechanisms that contribute to the development of heart muscle disease and heart failure. A longstanding interest has been the role of tumor necrosis factor in the development of the heart failure phenotype. More recently we have been studying the role of adenosine and adenosine receptor subtypes in the development of cardiac hypertrophy and failure. Studies focus on a group of novel transgenic mice that exhibit both constitutive and controlled over-expression of selective adenosine receptor sub-types as well as on mice with genetically altered signaling through the various G-protein-coupled and G-protein-regulated signaling pathways. A second major focus of the laboratory is to understand how polymorphisms in the genes encoding the various signaling proteins influence outcome and response to pharmacologic or surgical therapy in patients with heart failure. These studies include both polymorphism-specific association studies as well as genome wide studies using numerous genetic markers.
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Arthur M. Feldman, M.D., Ph.D.