Mani S. Kavuru, MD

Contact Dr. Kavuru

834 Walnut Street
Suite 650
Philadelphia, PA 19107

(215) 955-6591
(215) 955-0830 fax

Medical School
Northeastern Ohio Universities College of Medicine - 1984

Residency
Cleveland Clinic

Fellowship
Cleveland Clinic

Board Certification
Pulmonary Disease
Critical Care Medicine
Internal Medicine

Hospital Appointment
Thomas Jefferson University Hospital
Methodist Hospital Division of Thomas Jefferson University Hospital

University Appointment
Professor of Medicine, 2010

Research and Clinical Interests
Asthma, Sarcoidosis, Pulmonary Alveolar Proteinosis and rare lung disease, pulmonary function testing, fellow education and research, bronchoscopy, and critical care

Publications

Most Recent Peer-reviewed Publications

1. Alveolar macrophage cathelicidin deficiency in severe sarcoidosis
2. Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
3. Alveolar macrophage activation in obese patients with obstructive sleep apnea
4. An open-label trial of rituximab therapy in pulmonary alveolar proteinosis
5. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes
6. Inflammatory profile and response to anti-tumor necrosis factor therapy in patients with chronic pulmonary sarcoidosis
7. Restoration of PPARγ reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice
8. Sleep and metabolism: An overview
9. Montelukast added to fluticasone propionate does not alter inflammation or outcomes
10. Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism
11. PPARγ regulates the expression of cholesterol metabolism genes in alveolar macrophages
12. Alveolar proteinosis syndrome: Pathogenesis, diagnosis, and management
13. Changes in chest roentgenogram of sarcoidosis patients during a clinical trial of infliximab therapy: Comparison of different methods of evaluation
14. Deletion of PPARγ in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
15. A novel 1,25-dihydroxyvitamin D - Activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP)
16. Efficacy of infliximab in extrapulmonary sarcoidosis: Results from a randomised trial
17. ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis
18. Gene-environment interactions in sarcoidosis: challenge and opportunity
19. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health
20. Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement

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