Wayne Bond Lau, MD

Contact Dr. Lau

Center for
Translational Medicine
1025 Walnut Street
College Building, Suite 808
Philadelphia, PA 19107

(215) 955-8894

Medical School
Jefferson Medical College

Residency
Thomas Jefferson University Hospital, Emergency Medicine

Board Certification
American Board of Emergency Medicine

University Appointment
Assistant Professor of Emergency Medicine

Research and Clinical Interests
Cardiovascular Ischemia/Reperfusion Injury

Publications

Most Recent Peer-reviewed Publications

1. Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion
2. Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2
3. Reduced high-molecular-weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients
4. Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia
5. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK- PGC-1α signaling contributing to increased vulnerability in diabetic heart
6. A Comparison of the Prevalence of Lead-Contaminated Imported Chinese Ceramic Dinnerware Purchased Inside Versus Outside Philadelphia's Chinatown
7. The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury
8. Increased susceptibility to metabolic syndrome in adult offspring of angiotensin type 1 receptor autoantibody-positive rats
9. In reply
10. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart
11. A Patient with a large pulmonary saddle embolus eluding both clinical gestalt and validated decision rules
12. Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats
13. Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection
14. Response to letter regarding article, "signature MicroRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection"
15. Hypoadiponectinaemia in diabetes mellitus type 2: Molecular mechanisms and clinical significance
16. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway
17. Systemic adiponectin malfunction as a risk factor for cardiovascular disease
18. Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms
19. Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells
20. Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice

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