Charlene Williams, Ph.D.

Contact Dr. Williams

Center for Translational Medicine
1025 Walnut Street, Suite 403
Philadelphia, PA 19107

(215) 503-4837
(215) 503-5731 fax

Graduate School
Rutgers University

Degree
Ph.D., Biochemistry, 1983

Post-doctoral Fellowship
NRSA, Coriell Institute, Camden, NJ

University Appointment
Assistant Professor, Thomas Jefferson University, 1991
Associate Professor, Thomas Jefferson University, 1996
Adjunct Associate Professor, Drexel University, 1996-1997
Adjunct Associate Professor, Wayne State University, 1998-2002
Professor, Thomas Jefferson University, 2002

Research and Clinical Interests
Molecular genetics of osteo- and inflammatory arthropathies.

Structural Biology, cell biology and biochemistry of gene products associated with the development of certain arthropathies such as chondrocalcinosis and Blau syndrome.

Role of ANK in renal stone disease.

Publications

Most Recent Peer-reviewed Publications

1. The inorganic phosphate/inorganic pyrophosphate axis in the mineralization of cartilage and bone
2. The genetics of osteoarthritis
3. Two-stage biological treatment of olive mill wastewater with whey as co-substrate
4. Transforming growth factor-β1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation
5. New developments in the epidemiology and genetics of gout
6. Role of the progressive ankylosis gene in cartilage mineralization
7. Skeletal dysplasias and the osteoarthritic phenotype
8. Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH
9. Mutations in ANKH cause chondrocalcinosis
10. CARD15 mutations in familial granulomatosis syndromes: A study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy
11. The leatherback turtle, Dermochelys coriacea, exhibits both polyandry and polygyny
12. High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus
13. Additional techniques to improve microfiltration
14. Origin of loggerhead turtles stranded in the northeastern United States as determined by mitochondrial DNA analysis
15. Inferences on the phylogenetic relationships of Succineidae (Mollusca, Pulmonata) based on 18S rRNA gene
16. Coagulation and anaerobic digestion of tannery wastewater
17. Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition
18. Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1
19. Anesthesia for an achondroplastic dwarf with bilateral vocal cord granuloma: Use of a Xomed Hunsaker Mon-Jet ventilation tube
20. First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q

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