Center for Translational Medicine
Research at the Center
Eugene Feiner Laboratory for Vascular Biology & Thrombosis
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George Zallie & Family Laboratory for Cardiovascular Gene Therapy
From Research to the Power to Cure
The Center for Translational Medicine at Jefferson is primarily focused on bridging cutting-edge basic research with clinical medicine in order to more efficiently translate new discoveries at the bench to the realization of improved patient care.
Our Center, which is at the forefront of academic medicine, creates a new culture of collaboration and cooperation, merging a world-class team of basic science investigators with Jefferson’s renowned physicians and clinical investigators.
Research
The research activities of the Center for Translational Medicine are broad and multi-focal. As the number-one killer of both men and women in the U.S., our Center has particular interest and expertise in the area of cardiovascular, blood and pulmonary diseases.
Center laboratories study the regulation and signaling of many molecules vital in the progression in heart muscle diseases utilizing novel genetically engineered mouse models or viral-mediated myocardial gene delivery. Targets include Cellular Receptors, Kinases and Cell Adhesion Proteins (Most, Radice and Chan).
We also study cellular and molecular mechanisms of cardiovascular development in vertebrates (Astrof).
Diseases in the vasculature (Peppel and Sun), Platelets and mitochondrial calcium and reactive oxygen species signaling in human diseases (Sheu).
Finally, our center also leading research in Viral Vector development and Small Animal Surgery.
In the News
12/19/12 — Jifen Li, PhD, was awarded a one-year grant from the W.W. Smith Charitable Trust
10/10/12 — Loss of Protective Heart Failure Protein Linked to Critical Limb Ischemia
08/06/12 — Stephen Hurst was awarded a position on the pre-doctoral training grant
07/06/12 — Tenure Track Faculty Positions Available in Cardiovascular Sciences
02/21/12 — Sophie Astrof, Ph.D., received an AHA Innovative Research Grant to study regulatory mechanisms of gene expression in cardiac neural crest stem cells.
08/29/11 — New Gene Therapy to Reverse Heart Failure Ready for Clinical Trials
