Eugene P. Kennedy, MD
Assistant Professor, Surgery

Contact Dr. Kennedy

1025 Walnut Street
Room 605
Philadelphia, PA 19107

(215) 955-9402

Education
MD, University of Virginia, 1996

University Appointment
Assistant Professor, Surgery
Thomas Jefferson University

Research and Clinical Interests
My interest in therapeutic vaccines for cancer dates to my surgical residency and post-graduate training when I spent three years in the laboratory of Dr. Drew Pardoll at Johns Hopkins. There I worked on several novel approaches to improving the efficacy of GM-CSF based cellular vaccines through augmented costimulation.

Currently, I focus on the treatment of patients with pancreatic cancer. In additional to my clinical practice, I have ongoing projects in both clinical and translational research. I am currently in the process of submitting to the IRB a clinical trial for a phase II cell based pancreatic cancer vaccine. In the lab, I am collaborating with Drs. Brody and Witkiewicz on several projects. We are evaluating the role of Indoleamine 2,3-Dioxygenase (IDO) in pancreatic cancer. The goal of this project is to assess the potential of IDO inhibition as an adjuvant to conventional or vaccine based cancer therapy. Additionally, we are also looking at the humoral response of patients to pancreatic cancer, identifying and developing human antibodies against Prostate Stem Cell Antigen (PSCA) for diagnostic and therapeutic purposes.

Publications

1. Hitler's gift and the era of biosynthesis.
2. Domains of Escherichia coli acyl carrier protein important for membrane- derived-oligosaccharide biosynthesis
3. UTP:α-D-glucose-1-phosphate uridylyltransferase of Escherichia coli: Isolation and DNA sequence of the galU gene and purification of the enzyme
4. Sailing to Byzantium
5. Isolation and characterization of Escherichia coli mutants blocked in production of membrane-derived oligosaccharides
6. Detection and separation of Rhizobium and Bradyrhizobium Nod metabolites using thin-layer chromatography.
7. Membrane-derived oligosaccharides affect porin osmoregulation only in media of low ionic strength
8. Mechanisms of regulation of the biosynthesis of membrane-derived oligosaccharides in Escherichia coli
9. A novel highly unsaturated fatty acid moiety of lipo-oligosaccharide signals determines host specificity of Rhizobium
10. Biosynthesis of membrane-derived oligosaccharides: Membrane-bound glucosyltransferase system from Escherichia coli requires polyprenyl phosphate
11. Biosynthesis and excretion of cyclic glucans by Rhizobium meliloti 1021
12. Isolation of the Rhizobium leguminosarum NodF nodulation protein: NodF carries a 4'-phosphopantetheine prosthetic group
13. Isolation and characterization of the constitutive acyl carrier protein from Rhizobium meliloti
14. Isolation and properties of acyl carrier protein phosphodiesterase of Escherichia coli
15. Osmotic regulation of biosynthesis of membrane-derived oligosaccharides in Escherichia coli.
16. The function of acyl carrier protein in the synthesis of membrane-derived oligosaccharides does not require its phosphopantetheine prosthetic group.
17. Cyclic glucans produced by Agrobacterium tumefaciens are substituted with sn-1-phosphoglycerol residues
18. Metabolism and function of membrane lipids
19. Transfer of phosphoethanolamine residues from phosphatidylethanolamine to the membrane-derived oligosaccharides of Escherichia coli
20. Regulation of the balanced synthesis of membrane phospholipids. Experimental test of models for regulation in Escherichia coli

(This list reflects the most recent 20 publications)