Joseph E. Rabinowitz, PhD
Research Assistant Professor

Contact Dr. Rabinowitz

1025 Walnut Street
Room 403
Philadelphia, PA 19107

(215) 503-5590

Education
Education

University Appointment
Assistant Professor
Translational Medicine
Thomas Jefferson University

Research and Clinical Interests
I work with 9 serotypes of AAV and am planning to develop other parvovirus delivery systems.

Research Support
Ongoing Research Support:

AHA SDG (Rabinowitz)
American Heart Association
Evaluation of AAV Serotype Modification for Gene Delivery to Cardiac Tissue
The goals of this project are to test various alterations in the virion of AAV serotypes for heart tropism utilizing both mutagenesis and trancapsidation of serotype capsid subunits approaches.

Ro1-HL076646 (Zangrilli)
NIH/NHLBI
Regulation of Inflammation in Asthma by Fas Ligand
Role: Researcher
The goal of this project is to develop viruses for airway epithelial transduction. Initially this will utilize the nine serotypes of Adeno-associated virus then extending to lentiviral mediated transduction.

Publications

1. Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process
2. Coordinated regulation of cardiac Na+/Ca2+ exchanger and Na+-K+-ATPase by phospholemman (FXYD1)
3. MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction
4. Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles
5. AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve
6. Phase 1 gene therapy for duchenne muscular dystrophy using a translational optimized AAV vector
7. S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes
8. A pharmacokinetic analysis of molecular cardiac surgery with recirculation mediated delivery of βARKct gene therapy: Developing a quantitative definition of the therapeutic window
9. Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo
10. The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes
11. Regulation of in vivo cardiac contractility by phospholemman: Role of Na +/Ca 2+ exchange
12. The inotropic peptide βaRKct improves βaR responsiveness in normal and failing cardiomyocytes through Gβγ-mediated L-type calcium current disinhibition
13. Phospholemman: A novel cardiac stress protein
14. Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart
15. Myocardial adeno-associated virus serotype 6-βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
16. Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection
17. Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue
18. Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency
19. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
20. Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors

(This list reflects the most recent 20 publications)