Scott A. Waldman, MD, PhD
Professor, Pharmacology & Experimental Therapeutics

Contact Dr. Waldman

132 S. 10th Street
Suite 1170
Philadelphia, PA 19107

(215) 955-6086

Education
Education

University Appointment
Professor
Pharmacology & Experimental Therapeutics
Department of Biochemistry and Molecular Pharmacology
Thomas Jefferson University Jefferson Medical College

Research and Clinical Interests
Molecular mechanisms regulating guanylyl cyclases, Transcription factors mediating tissue-specific expression of proteins, Molecular markers and cancer, Cyclic GMP and the regulation of the cell cycle, differentiation, metabolic programming and DNA damage and repair. Experimental therapeutics.

Publications

1. Systems-based discovery advances drug development
2. Translational medicine individualizes healthcare discovery, development and delivery
3. Obesity pharmacotherapy: What is next?
4. Immunotherapeutic strategies to target prognostic and predictive markers of cancer
5. Guanylyl cyclase C as a biomarker in colorectal cancer
6. GUCY2C: at the intersection of obesity and cancer
7. Advancing pharmacometrics and systems pharmacology
8. Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer
9. Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer
10. GUCY2C molecular staging personalizes colorectal cancer patient management
11. Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C
12. Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes
13. Molecular staging individualizing cancer management
14. Clinical pharmacology therapeutics 2011: Year in review
15. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
16. The Value Proposition of Molecular Medicine
17. Knowledge cycle transforms therapeutic innovation
18. GUCY2C-targeted cancer immunotherapy: Past, present and future
19. Patient-centric clinical pharmacology advances the path to personalized medicine
20. Cardiovascular health: The global challenge

(This list reflects the most recent 20 publications)