Christopher V. Chambers, MD
 Professor & Director, Clinical Trials

Contact Dr. Chambers

1015 Walnut Street
Suite 401
Philadelphia, PA 19107

(215) 955-2357

Education
A.B. Princeton University, 1976
M.D. Duke University School of Medicine, 1980
Residency, Family Medicine, Thomas Jefferson University Hospital, 1983
Fellowship, Adolescent Medicine, University of California, San Francisco, 1985
Board Certified, Family Medicine
Board Certified, Adolescent Medicine

University Appointment
Professor and Director, Clinical Trials
Family and Community Medicine
Thomas Jefferson University

Research and Clinical Interests
Over the past 10 years, I have been Principal Investigator for more than 10 clinical trials involving vaccines, primarily the HPV (human papilloma virus) vaccine. These phase II and phase III trials have been safety and efficacy studies in various populations including adolescent and young adult women, ages 15-25; older women, ages 26-45; MSMs (men who have sex with men); as well as immunologic studies of the HPV vaccine given in various combinations with other immunizations in adolescents and a head to head trial of the GSK HPV vaccine and the Merck HPV vaccine. In the international pivotal trial of the GSK vaccine, our site was the second highest enroller in the world. In the study of MSMs, we were the third leading enroller.
In addition to our HPV studies, we have also completed a clinical and immunological study of two FDA-approved influenza vaccines. In 2008, we are scheduled to participate in a study of the pertussis vaccine in the elderly and another influenza vaccine study.
My clinical department has nearly 80,000 outpatient visits per year. The department also has several clinical satellite offices and its faculty staffs the Philadelphia Senior Center, which serves another 7,000 clients. The chair of my department, Richard Wender, MD, has helped me build the infrastructure to attract and complete vaccine trials which are consistent with the department’s clinical and research commitment to prevention and chronic disease management.

Publications

1. Effective Strategies to Improve the Management of Heart Failure
2. Cancer Vaccines
3. Immunologic non-inferiority of a newly licensed inactivated trivalent influenza vaccine versus an established vaccine: A randomized study in US adults
4. Screening and Prevention: Cervical Cancer
5. Hematuria: etiology and evaluation for the primary care physician.
6. Development of a scale to measure adults' perceptions of health: Preliminary findings
7. Out-of-hospital cardiac arrest and use of automated external defibrillators
8. Neurocognitive development in adolescent males or adolescent boys are from Pluto
9. Primary care physician beliefs regarding usefulness of self-monitoring of blood pressure
10. A Cohort Study of NSAID Use and the Management of Related Gastrointestinal Symptoms by Primary Care Patients
11. Exercise promotion for patients with significant medical problems
12. Asthma controller medications: What do patients want?
13. Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices
14. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma
15. Attitudes toward sexual responsibility and parenting: An exploratory study of young urban males
16. Attitudes toward sexual responsibility and parenting: An exploratory study of young urban males
17. The Princess and the Pea: An Unusual Complication after a Laparoscopic Cholecystectomy
18. The importance of advance directives in primary care
19. Conversion disorder presenting as gait disturbance in an adolescent.
20. A national survey of admissions criteria and processes in selected allied health professions.

(This list reflects the most recent 20 publications)