Scott Dessain, MD, PhD
Associate Professor, Medical Oncology

Contact Dr. Dessain

1015 Walnut Street
Room 812
Philadelphia, PA 19107

(215) 955-4160

Education
B.A., Brown University, Biochemistry with Honors, 1985
M D, Yale University School of Medicine, Ph D, Biology
Diplomate, American Board of Internal Medicine, 1997
Subspecialty Certification, Medical Oncology, 2001
Medical Licensure, Pennsylvania, 2002

University Appointment
Associate Professor
Medical Oncology
Thomas Jefferson University

Research and Clinical Interests
My main interest is human antibodies that bind infectious pathogens and cancer cell markers. My lab has been collaborating with Eugene Kennedy, MD and Jonathan Brody, PhD of Surgery to develop a project to clone human antibodies that bind to pancreatic cancer cells. Similarly, my lab has worked with Dr. Takami Sato to analyze the antibody immune response that can occur in melanoma patients and is directed at melanoma cancer cell line antigens. Membership in the JVC will facilitate collaborations with others involved in vaccine research. It will enable the parallel study of the T-cell and B-cell immune responses to different vaccines and immunizing stimuli.

Publications

1. Molecular assembly of botulinum neurotoxin progenitor complexes
2. Hemophagocytic lymphohistiocytosis: A syndrome with diverse etiologies and treatment options
3. Patients hospitalized with pH1N1 influenza in an academic community medical center
4. Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein
5. Inherent anti-amyloidogenic activity of human immunoglobulin γ heavy chains
6. Combination Antiplatelet Therapy for Secondary Stroke Prevention: Enhanced Efficacy or Double Trouble?
7. Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: A case report
8. Human Antibody Therapeutics for Viral Disease: Preface
9. Exploring the native human antibody repertoire to create antiviral therapeutics
10. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
11. Human monoclonal antibody and vaccine approaches to prevent human rabies
12. Neutralization of Botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain
13. Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins
14. A natural human IgM antibody that neutralizes botulinum neurotoxin in vivo
15. A human monoclonal antibody that binds serotype A botulinum neurotoxin
16. Treatment of Adenovirus Disease in Stem Cell Transplant Recipients with Cidofovir
17. A mouse model of human breast cancer metastasis to human bone
18. High efficiency creation of human monoclonal antibody-producing hybridomas
19. Enumeration of the simian virus 40 early region elements necessary for human cell transformation
20. Erratum: Enumeration of the simian virus 40 early region elements necessary for human cell transformation (Molecular and Cellular Biology (2002) 22:7 (2111-2123))

(This list reflects the most recent 20 publications)