Beverly A. S. Reyes, Ph.D.

Contact Dr. Reyes

900 Walnut St.
Suite 417
Philadelphia, PA 19107

215-503-5857
215-503-9238 fax

Graduate School
PhD, Nagoya University, Nagoya, Japan
DVM, Gregorio Araneta University Foundation, Manila, Philippines

University Appointment
Research Assistant Professor (2008)

Research and Clinical Interests
My research focuses on elucidating the neural mechanism by which corticotropin-releasing factor, the hypothalamic neurohormone that initiates the endocrine limb of stress response, and opioids alter the monoaminergic circuits to stress. In addition, my research focuses on adaptations in monoaminergic circuits to drugs of abuse such as morphine and cannabinoids.

Publications

Most recent Peer-reviewed Publications

1. Cellular Adaptations of Dorsal Raphe Serotonin Neurons Associated with the Development of Active Coping in Response to Social Stress
2. Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression
3. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
4. Stress-induced sensitization of cortical adrenergic receptors following a history of cannabinoid exposure
5. Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
6. HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes
7. Intracisternal rSV40 administration provides effective pan-CNS transgene expression
8. Molecular and cellular sex differences at the intersection of stress and arousal
9. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons
10. An evaluation of neuroplasticity and behavior after deep brain stimulation of the nucleus accumbens in an animal model of depression
11. HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy
12. Bone marrow-derived cells migrate to line the vessels of the CNS: Opportunities for gene delivery to CNS vasculature
13. Amygdalar peptidergic circuits regulating noradrenergic locus coeruleus neurons: Linking limbic and arousal centers
14. Gene transfer to the cerebellum
15. Agonist-induced internalization of kappa-opioid receptors in noradrenergic neurons of the rat locus coeruleus
16. Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats
17. Sex differences in corticotropin-releasing factor signaling and trafficking
18. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: Potential role in female vulnerability to stress-related psychopathology
19. HIV-1 gp120-induced injury to the blood-brain barrier: Role of metalloproteinases 2 and 9 and relationship to oxidative stress
20. Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120 - Protection by gene delivery of antioxidant enzymes

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