John L. Farber, MD

Contact Dr. Farber

132 South 10th Street
Main Building, Suite 285
Philadelphia, PA 19107

(215) 503-5066
(215) 923-2218 fax

Medical School
B.A., Reed College, 1962

San Francisco, University of California, MD

Board Certification
Board certification, American Board of Pathology, Diplomate, Anatomic Pathology

University Appointment
Professor

Other Professional Appointments
EXTRACURRICULAR ACTIVITIES (1997-present)
Board of Scientific Counselors, National Institute of Environmental Health Sciences, 1997-Present

EDITORIAL BOARDS (1997-present):
Experimental and Molecular Pathology 1983-Present
Cell Biology and Toxicology 1985-present
Toxicologic Pathology 1988-1997
Chemico-Biological Interactions 1990-1998
Cell Death and Differentiation 1994-Present
Toxicology In Vitro 1992-Present
International Hepatology Communications 1992-Present
Modern Pathology 1995-Present
Human Pathology 1998-Present

Research and Clinical Interests
Cell Death; Cellular Pathology; Diabetes; Digestive Diseases And Disorders; Digestive System; Kidney (Renal) Functions; Kidney Disease; Mitochondria; Necrosis; Urology

Biochemical mechanisms of cell injury in ischemia of liver cell necrosis; biochemical toxicology of activated oxygen; chemical carcinogenesis.

Publications

Most recent Peer-reviewed Publications

1. Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature
2. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer
3. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy
4. Peritransplant kidney biopsies: Comparison of pathologic interpretations and practice patterns of organ procurement organizations
5. Tacrolimus-induced thrombotic microangiopathy: Natural history of a severe, acute vasculopathy
6. Segmental arterial mediolysis: Report of 2 cases and review of the literature
7. Sirolimus-induced pneumonitis complicated by pentamidine-induced phospholipidosis in a renal transplant recipient: A case report
8. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression
9. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis
10. Cyclophilin D controls mitochondrial pore - Dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice
11. GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice
12. Effects of cardiac-restricted overexpression of the A2A adenosine receptor on adriamycin-induced cardiotoxicity
13. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of bax translocation in HeLa cells
14. Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin.
15. Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin
16. Zinc Replenishment Reverses Overexpression of the Proinflammatory Mediator S100A8 and Esophageal Preneoplasia in the Rat
17. Detailing the role of bax translocation, cytochrome C release, and perinuclear clustering of the mitochondria in the killing of hela cells by TNF
18. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: Inefficacy of genetic or pharmacological disruption of COX-2
19. Fez1/Lzts1 Absence Impairs Cdk1/Cdc25C Interaction during Mitosis and Predisposes Mice to Cancer Development
20. The Presence of B-Cell Nodules Does Not Necessarily Portend a Less Favorable Outcome to Therapy in Patients With Acute Cellular Rejection of a Renal Allograft

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