New York University, 1955
Jacob and Sophie Rubin Professor
Research and Clinical Interests
Dr. Fred Gorstein is the Jacob and Sophie Rubin Professor in the Department of Pathology, Anatomy and Cell Biology. Prior to joining the department in 1994, he served as the Chairman of the Department of Pathology at Vanderbilt University in Nashville, Tennessee. Dr. Gorstein received his undergraduate education at the University Heights College of New York University and his MD from NYU School of Medicine in 1955. He trained in internal medicine and hematology on the NYU service of Bellevue Hospital in New York City after which he joined the Pathology Department of the same institution as a resident and USPHS postdoctoral fellow in Pathology in the laboratory of Dr. Baruj Benacerraf. Under the supervision of Dr. Benacerraf and subsequently, Dr. Peter Miescher, Dr. Gorstein investigated the mechanisms of autoimmune disease and immune platelet destruction. These studies, conducted almost a decade prior to the discovery of T and B cells, demonstrated the importance of lymphocytes in the induction of (auto) immune damage. Subsequently, Dr Gorstein joined the laboratory of Germ-Free Animal Research (NIAID) at NIH where utilizing a germ-free system, he and his co-worker, Dr. Bruce Phillips, demonstrated the critical role of a bacterial component in initiating amebic infection in the germ-free animal. In collaboration with Dr. Bertram Gesner, he demonstrated that autoimmune murine thyroiditis could be transferred with lymphocytes. Dr. Gorstein has had a long time interest in gynecologic pathology and served as the director of the combined NYU-Bellevue Hospital Gynecologic Pathology service for several years. In collaborative studies with Drs. Ann Thor, William Rodgers, and Kevin Osteen, utilizing cultured endometrial cells, they demonstrated the role of epithelial-stromal interaction in the regulation of metalloproteinase expression in normal endometrium and endometriosis. These and other studies have been published in over 85 peer-reviewed publications.
Over a period of more than 28 years Dr. Gorstein served as the associate editor and editor-in-chief of Human Pathology until 2005. During this time more than 7500 original research studies were published in the Journal. The Journal was established based on the vision of Dr. Stanley Robbins and several of his colleagues. It was their concept that clinical pathologic correlation and translational research was the keystone of our understanding of the pathogenesis, diagnosis and treatment of disease. The Journal has attempted to be true to these ideals. Monthly editorials, commentaries and open forums provided a voice for the expression of wide-ranging opinions on many topics of contemporary interest to pathologist and physicians in other specialties. Dr. Gorstein has had a long term and continuing interest in undergraduate and graduate education. He has served as the director of Residency Training at two institutions and has been a strong advocate for a competency-based structure for residency programs for more than a decade. Dr. Gorstein has participated in the training of more than 250 residents and clinical fellows in pathology over the past 40 years.
He served as the interim chairman and chairman of Pathology at Vanderbilt University from 1986 until 1994, and more recently as chairman at Thomas Jefferson University until October 2008. He has participated in intramural and national organizations concerned with health policy issues and medical administration. As the chair of the College of American Pathologists Education Committee, he was instrumental in establishing the CAP Foundation Scholars program. He served as the president of UAREP (Universities Associated with Research and Education in Pathology), was an officer of many boards of numerous organizations including the American Registry of Pathology and the Council of the Association of Pathology Chairs. He has been the recipient of distinguished service awards from Vanderbilt University and the Association of Pathology Chairs.
Health Care Policy