Ph.D., Moscow Institute of Physics and Technology, Biophysics, 1986
Research Assistant Professor
Research and Clinical Interests
Research interests are focused on the experimental and computational analyses of growth factor and hormone receptor signaling networks. We apply a cross-disciplinary approach that combines experimental studies, nonlinear systems analysis and interactive computational models to achieve a qualitative understanding of integrated signaling responses in normal and malignant cells. Currently our projects encompass: studies of the crosstalk between epidermal growth factor and prolactin-mediated signaling in breast cancer cells; molecular mechanisms and components controlling an alternative MEK-independent route of ERK activation in ER-positive breast cancer cells and the effects of ethanol on this compensatory circuit; system-level research of deregulated invasion and metastasis of squamous carcinoma cells. Through a combination of network analysis, mathematical modeling and experimentation, we plan to identify key switches that promote carcinogenesis and develop novel strategies to effectively treat human cancers with molecular therapeutics.