Jean-Marc Navenot, Ph.D.

Contact Dr. Navenot

1020 Locust Street
Jefferson Alumni Hall,
Suite 336C
Philadelphia, PA 19107

(215) 503-5066

Medical School
Ph. D., University of Nantes, France, 1996

University Appointment
Research Assistant Professor

Publications

Most recent Peer-reviewed Publications

1. Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes
2. MicroRNA profiling in lung cancer reveals new molecular markers for diagnosis
3. Paradoxical downregulation of CXC chemokine receptor 4 induced by polyphemusin II-derived antagonists
4. The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma
5. Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists
6. Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis
7. KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis
8. Physical association of GPR54 C-terminal with protein phosphatase 2A
9. Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis
10. Heat shock response in CHO mammalian cells is controlled by a nonlinear stochastic process
11. SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54
12. Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy
13. Structure-activity relationship study on small peptidic GPR54 agonists
14. Characterization of constitutively active mutants of G protein-coupled receptors.
15. Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity
16. Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: A potential mechanism for the metastasis suppressor activity of kisspeptins
17. Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2
18. S-protein is expressed in necrotic fibers in Duchenne muscular dystrophy and polymyositis
19. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
20. Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1

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