Dr. Schwaber James S. Schwaber, Ph.D.

Contact Dr. Schwaber

1020 Locust Street
Jefferson Alumni Hall, Suite 381
Philadelphia, PA 19107

(215) 503-7823

Medical School
Ph. D., University of Miami, 1973

University Appointment
Associate Professor

Director of Daniel Baugh Institute for Functional Genomics and Computational Biology; Department of Pathology, Anatomy & Cell Biology

Other Professional Appointments
Adjunct Professor Chemical Engineering, University of Delaware

Research and Clinical Interests
Dr. Schwaber uses systems biology approaches in mammalian brain to study adaptive neuronal processes. Specifically his interests involve mechanisms by which hypertension arises in homeostatic cardiorespiratory regulatory circuits, by which the symptoms of alcohol withdrawal are produced and by which phase shifting of light causes the brain's master clock to reorganize circadian behavior.

 

Publications

Most recent Peer-reviewed Publications

  1. Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal
  2. Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance
  3. Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus
  4. Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
  5. Adaptive transcriptional dynamics of A2 neurons and central cardiovascular control pathways
  6. Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network
  7. The effect of biological variability on the angiotensin II gene regulatory network in the central regulation of blood pressure
  8. Elucidating the transcriptional regulatory network underlying the Nts response to acute hypertension
  9. A control system hypothesis of the N-methyl-D-aspartate glutamate receptor's role in alcoholism and
  10. Modeling the control of an excitatory neurotransmitter receptor during alcoholism and alcohol withdrawal
  11. A fast carrier chromatin immunoprecipitation method applicable to microdissected tissue samples
  12. Dynamic transcriptomic response to acute hypertension in the nucleus tractus solitarius
  13. From promoter analysis to transcriptional regulatory network prediction using PAINT.
  14. Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus
  15. Quantifying gene network connectivity in silico: Scalability and accuracy of a modular approach
  16. Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling
  17. Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus
  18. A universal reference sample derived from clone vector for improved detection of differential gene expression
  19. Modeling the VPAC2-activated cAMP/PKA signaling pathway: From receptor to circadian clock gene induction
  20. Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: The nucleus tractus solitarius

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