Dr. Walker Janice L. Walker, Ph.D.

Contact Dr. Walker

1020 Locust Street
Jefferson Alumni Hall, Suite 571
Philadelphia, PA 19107

(215) 503-7845

Medical School
Ph. D., Thomas Jefferson University, 2000

University Appointment
Research Assistant Professor

Research and Clinical Interests
The role of unique precursors for the mesenchymal cells involved in injury response and the lens fibrotic disease Posterior Capsule Opacification, the role of mesenchymal cells in directing collective migration/invasion as well as processes critical to cancer cell progression and metastasis.

 

Publications

Most recent Peer-reviewed Publications

  1. Unique precursors for the mesenchymal cells involved in injury response and fibrosis
  2. Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions
  3. Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer
  4. Integrins in lens development and disease
  5. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: Insights into the formation of acinar and ductal structures
  6. γ-Secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung
  7. A Skp2 autoinduction loop and restriction point control
  8. Activation of Src kinases signals induction of posterior capsule opacification
  9. ERK activity and G1 phase progression: Identifying dispensable versus essential activities and primary versus secondary targets
  10. Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts
  11. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression
  12. Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension
  13. A signaling role for the uncleaved form of 36 integrin in differentiating lens fiber cells
  14. Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinases
  15. Role for α6 integrin during lens development: Evidence for signaling through IGF-1R and ERK
  16. α6 Integrin is regulated with lens cell differentiation by linkage to the cytoskeleton and isoform switching
  17. Integrins and development: How might these receptors regulate differentiation of the lens
  18. Coordinated integrin-matrix ligand expression during lens differentiation
  19. POSSIBLE REGULATORY ROLE for a6 INTEGR1N in LENS DIFFERENTIATION
  20. Kinetics of cytolytic T lymphocyte binding to target cells in suspension

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