Dr. Tykocinski Mark L. Tykocinski, M.D.

Contact Dr. Tykocinski

1025 Walnut Street College
Room 100
Philadelphia, PA 19107

(215) 955-1628

Medical School
New York University, New York 1978
Columbia-Presbyterian Medical Center, New York City 1979

Residency
New York University, 1982

Fellowship
National Institute of Allergy and Infectious Diseases, Laboratory of Immunogenetics, NIH, Maryland 1984

University Appointment
Anthony and Gertrude DePalma Professor
Dean, Jefferson Medical College

Research and Clinical Interests

Publications

Most recent Peer-reviewed Publications

  1. Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells
  2. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
  3. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling
  4. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14
  5. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis
  6. CTLA-4·Ig converts naive CD4+ CD25- T cells into CD4+CD25+ regulatory T cells
  7. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
  8. CTLA-4·FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals
  9. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-κB binding sites
  10. CD40·FasL inhibits human T cells: Evidence for an auto-inhibitory loop-back mechanism
  11. α2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: Insights into differential effects on CD45RO and CD45RA T cells
  12. CTLA-4·FasL inhibits allogeneic responses in vivo
  13. Pathology as the enabler of human research
  14. Differential regulation of Th1/Th2 cytokine responses by placental protein 14
  15. Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production
  16. New designs for cancer vaccine and artificial veto cells: An emerging palette of protein paints
  17. CTLA-4 · FasL induces alloantigen-specific hyporesponsiveness
  18. Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45
  19. Quantitative interplay between activating and pro-apoptotic signals dictates T cell responses
  20. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation

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