Dr. Leeper Dennis B. Leeper, Ph.D.

Contact Dr. Leeper

111 South 11th Street
Bodine Center
Philadelphia, PA 19107

(215) 955-8092
(215) 955-5825 fax

University of Iowa, Ph.D. (Radiation Biology)

Colorado State University, Mentor: William C. Dewey. (Cellular Radiation Biology)

Professional Societies
Radiation Research Society
Society of Thermal Medicine
American Association of Cancer Research
American Society of Therapeutic Radiology & Oncology Cell Proliferation Society
American Association for the Advancement of Science Sigma Xi

Associate Editor, Int. J. Hyperthermia (1985-present)
Member, Radiation Science Review Panel, Breast Cancer Research Program, U.S. Army Medical Research and Material Command (1995, 1996, 2009)
Secretary-Treasurer, Int. Assoc. Hyperthermic Oncology 2000-2004)
Eugene Robinson Award for Scientific Achievement, Society of Thermal Medicine (2002)
Invited North American Lecturer, 18th Japanese Congress of Hyperthermic Oncology, Sept. 8-9, 2001, Tokyo, Japan (2001)
President, North American Hyperthermia Society (1996-97)
Vice-president, Int. Assoc. Hyperthermic Oncology (1996-97)
Co-Chairman, U.S./China Meeting on Role of Hyperthermia in Radiation Oncology - Beijing (1988)
Associate Editor, Int. J. Radiation Biology (1983-88)
Member, Diagnostic Radiology & Nuclear Medicine Study Section, National Institutes of Health (1983-87)
Scientific Award, American Cancer Society, Philadelphia Division for pioneering work in "Hyperthermia Research." (1986)
Councilor for Biology, Radiation Research Society (1983-86)
Chairman, Organizing Committee, North American Hyperthermia Group (1981-85)
Member, Training Grant Study Section, National Cancer Institute (1982-83)

University Appointment
Jefferson Medical College Committee on Research, Chairman:
Chairman: Thomas Jefferson University Radiation Safety Committee
Secretary-Treasurer, Society of Sigma Xi
Member: Committee on Research, Radiation Safety Committee, IACUC, Committee on Appointments and Promotions
Professor, Molecular Radiation Biology

Research and Clinical Interests

  • Mechanisms of hyperthermia damage, interaction of hyperthermia with radiation and chemotherapy and integration into clinical treatment protocols.
  • Radiation-induced activation of cell cycle check points, inhibition of cell cycle progression and induction of apoptosis.
  • Role of the tumor microenvironment and metabolism in developing new patient tailored therapeutic modalities.
  • Tumor physiology
  • Growth at low pH, mechanisms of cellular adaptation and response to therapeutic agents: Hyperthermia, radiation therapy, chemotherapy.
  • Radiation Biology Education




Most recent Peer-reviewed Publications