Thomas Jefferson University - Timothy L. Manser, Ph.D.
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Timothy L. Manser, Ph.D.
Microbiology and Immunology
Professor and Chair
Jefferson Medical College
Thomas Jefferson University
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Mailing Address
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JAH 471, 1020 Locust Street
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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BA, University of California, San Diego, Biology, 1977
Ph.D, University of Utah, Biology, 1982
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Expertise and Research Interests
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Our laboratory''s interests center on the antigen-dependent stages of B cell differentiation in the mouse, leading to the generation of B cell memory and the control of B cell autoreactivity. We are investigating the mechanisms responsible for antigen-driven changes in the structure and function of the antibody repertoire during memory development, as well as the microenvironmental locales (particularly the germinal center (GC)) in which these changes take place. We are predominantly interested in the fate of B cells with autoreactive antigen receptors (either pre-existing or acquired via V region hypermutation) during memory B cell development. Additional projects concern the role of Fc receptors, the BAFF (BLys) pathway, follicular dendritic cells and T cells in the regulation of the B cell response.
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Other Expertise
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RECENT TEACHING EXPERIENCE
1991-present, Graduate and Medical School Courses in Immunology, Thomas Jefferson University
STUDY SECTIONS AND EDITORSHIPS
- Advisory Editor, The Journal of Experimental Medicine, 1991-1997
- Associate Editor, The Journal of Immunology, 1993-1999
- Permanent Member, NIH, NIAID Experimental Immunology Study Section, 1995-1999.
- Section Editor, The Journal of Immunology, 1999-2003
- Editor, BMC Immunology, 2004-present
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Keywords
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B lymphocyte, autoimmunity, immunological memory, immunological tolerance, lymphoid microenvironments
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Publications
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- Representative Publications Since 2001:
- Lentz, V. M. and T. Manser "Cutting Edge: Germinal Centers can be Induced in the Absence of T Cells" (2001) J. Immunol. 167: 15-20.
- Heltemes, L. and T. Manser "Level of BCR Surface Expression Influences both Positive and Negative Selection during Primary B Cell Development" (2002) J. Immunol., 169: 1283-1292.
- Notidis, E., L. Heltemes and T. Manser "Dominant, Heirarchical Induction of Self-tolerance During Foreign Antigen-Driven B Cell Development" (2002) Immunity 17: 317-327.
- Alabyev, B. and T. Manser "Bcl-2 Rescues the Germinal Center Response but does not Alter the Hypermutation Spectrum in MSH2 Deficient Mice" (2002) J. Immunol. 169: 3819-3824.
- Rahman, Z.S.M., S.P. Rao, S. Kalled and T. Manser "Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling Deficient Mice", (2003) J. Exp. Med. 198: 1157-1169.
- Heltemes-Harris, L.M., X. Liu and T. Manser, "Progressive Surface BCR Downregulation Accompanies Efficient Development of Anti-Nuclear Antigen B Cells to Mature, Follicular Phenotype"(2004) J. Immunol. 172: 823-833.
- Manser, T. "Textbook Germinal Centers?" (2004) J. Immunol. 172: 3369-3375.
- Rahman, Z.S.M. and T. Manser "B cells Expressing Bcl-2 and a Signaling-impaired BAFF-R Fail to Mature and are Deficient in the Formation of Lymphoid Follicles and Germinal Centers" (2004) J. Immunol. 173: 6179-6188.
- Liu, X. and T. Manser, "Antinuclear antigen B cells that downregulate surface BCR during development to mature, follicular phenotype do not display features of anergy in vitro" (2005) J. Immunol. 174: 4505-4515.
- Rahman, Z.S.M. and T. Manser, Failed Upregulation of the Inhibitory IgG Fc Receptor FcgRIIB on Germinal Center B cells in Autoimmune-prone Mice is not Associated with Deletion Polymorphisms in the Promoter Region of the FcgRIIB Gene (2005) J. Immunol. 175:1440-1449.
- Rahman, Z.S.M., B. Alabyev and T. Manser. FcgRIIB Regulates Autoreactive Primary Antibody Forming Cell, but not Germinal Center B Cell, Activity (2007) J. Immunol., 178: 897-907.
- Liu, X., L. J. Wysocki and T. Manser Autoantigen-B Cell Antigen Receptor Interactions that Regulate Expression of B Cell Antigen Receptor Loci (2007) J. Immunol., 178: 5035-5047.
- Alabyev, B. Z.S.M. Rahman and T. Manser "Quantitatively Reduced Participation of Anti-nuclear Antigen B Cells that Down Regulate BCR During Primary Development in the Germinal Center/memory B Cell Response to Foreign Antigen" (2007) J. Immunol., 178: 5623-5634.
- Rahman, Z.S.M., H. Niu, D. Perry, E. Wakeland, T. Manser, and L. Morel Expression of the Autoimmune Fcgr2b NZW Allele Fails to be Up-regulated in Germinal Center B Cells and Leads to Increased IgG Production (2007) Genes Immun. 8: 604-612.
- Coffey, F., X. Liu and T. Manser, Toll-like receptor 9 and other MyD88-dependent TLRs are not required for primary and foreign antigen driven development of an anti-chromatin B cell clonotype (2007) J. Immunol. 179: 6663-6672.
- Alabyev, B, R. Vuyyuru and T. Manser, Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen , (2008) Int. Immunol., in press.
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Individual Expertise profile of
Timothy L. Manser, Ph.D., Copyright © Timothy L. Manser, Ph.D..
Last Updated
by Timothy Manser, Ph.D. : Monday, September 15, 2008 10:29:04 AM
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