Thomas Jefferson University - Yuri K. Sykulev, M.D., Ph.D.
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Yuri K. Sykulev, M.D., Ph.D.
Microbiology and Immunology
Thomas Jefferson University
Jefferson Medical College
Department of Microbiology and Immunology
Associate Professor
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Mailing Address
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233 S 10th Street
BLSB650
Philadelphia, Pennsylvania 19107
United States
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Publications
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- Anikeeva, N., Mareeva, T., Liu, W., Sykulev, Y. (2009) Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on the infected cells? Clinical Immunology, 2009 130: 98-109. Epub 2008 Oct 8.
- Beal, A. M., Anikeeva, N., Varma, R., Cameron, T. O., Norris, P. J., Dustin, M. L., and Sykulev, Y. (2008) PKC¸ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J. Immunol., 181: 4815-24
- Mareeva T, Martinez-Hackert E., Sykulev, Y. (2008) How a TCR-like antibody recognizes MHC-bound peptide. J Biol. Chem., 283: 29053-9
- Anikeeva, N., Lebedeva, T., Clapp, A. R., Goldman, E. R., Dustin, M. L., Mattoussi, H., and Sykulev, Y. (2006) Quantum Dot/Peptide-MHC Biosensors reveal strong CD8-dependent Cooperation Between Self and Viral Antigens that Augment the T Cell Response, Proc. Natl. Acad. Sci. USA, 103: 16846-16851.
- Anikeeva, N., Martinez-Hackert, E., Kalams, S., Walker, B.D., Hendrickson, W. A. and Sykulev, Y.(2005) Structural basis for degenerate recognition of HIV Peptide Variants by Cytotoxic Lymphocytes. J. Biol. Chem., 281: 20205-20212.
- Norris, P.J., Stone, J.D., Anikeeva, N., Heitman, J.W., Wilson, I.C., Hirschkorn, D.F., Clark, M.J., Moffett, H.F., Cameron, T.O., Sykulev, Y., Stern, L.J., Walker, B.D. (2005) Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope. Molecular Immunology, 43:1349-57.
- Tatiana Lebedeva , Dustin, M., and Yuri Sykulev. Target cells contributions to killing through ICAM-1 organization and signaling. In Antigen Presenting Cell (Eds H. Kropshofer & A.B. Vogt), Wiley-VCH, Weinheim, pp. 199-206.
- Tatiana Lebedeva , Dustin, M., and Yuri Sykulev (2005). ICAM-1 co-stimulates target cells facilitating antigen presentation. Current Opinion in Immunology, 17:251-258.
- Nadia Anikeeva, Kristina Somersalo, Tasha N. Sims, V. Kaye Thomas, Mike L. Dustin and Yuri Sykulev (2005). Distinct role of LFA-1 in effective cytolytic activity of cytotoxic T lymphocytes. Proc.Natl. Acad. Sci. USA, 102:6437-42.
- Lebedeva, T., Anikeeva, N., Kalams, S.A., Walker, B.D., Gaidarov I., Keen, J. H., and Sykulev, Y. (2004) MHC-I-ICAM-1 interactions on the surface of target cells: implication for antigen presentation to cytotoxic T lymphocytes. Immunology, 113: 460-471.
- Mareeva, T., Lebedeva, T., Nadja Anikeeva, N., Manser, T. and Sykulev, Y. (2004) Antibody specific for a peptide-MHC complex: is it TCR-like? J. Biol. Chem., 279: 44243-44249.
- Somersalo, K., Anikeeva, N., Tasha N. Sims, Verda K. Thomas, Roland K. Strong, Thomas Spies, Lebedeva, T., Sykulev, Y., and Dustin, M.L. (2004) Cytotoxic T lymphocytes form an antigen independent ring junction. J. Clinical Investigation, 113: 49-57.
- Anikeeva, N., Lebedeva, T., Kalams, S. and Sykulev, Y. (2003) Soluble HIV-specific T-cell receptor: expression, purification and analysis of the specificity. J. Immunol. Methods, 277: 75-86.
- Anikeeva, N., Lebedeva, T., Krogsgaard, M., Tetin, S. Y., Martinez-Hackert, E., Kalams, S., Davis, M.M., and Sykulev, Y. (2003). Distinct molecular mechanisms account for the specificity of two different T-cell receptors. Biochemistry, 42:4709-4716.
- Philip J. Norris, Marina Sumaroka, Christian Brander, Howell F. Moffett, Steven L. Boswell, Tam Nguyen, Yuri Sykulev, Bruce D. Walker, Eric S. Rosenberg (2001). Multiple effector functions mediated by HIV-1-specific CD4+ T cell clones. J. Virol., 75: 9771-9779.
- Kageyama, S.,. Tsomides, T.J., Fukusen, N., Papayannopoulos, I. A., Eisen, H. N., and Sykulev, Y. (2001). Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule. J. Immunol., 166:3028-3034.
- Sykulev, Y. (2000). From T-cell receptor ligation to effector functions: affinity, kinetics and pattern recognition. The Immunologist, 9, No 3, 215-221.
- Sykulev, Y., Vugmeyster, Y., Brunmark, A., Ploegh, H. L., and Eisen, H.N. (1998). Peptide antagonism and T-cell receptor interactions with peptide-major histocompastibility (MHC) protein complexes. Immunity, 9, 475-483.
- Delaney, J., Sykulev, Y., Eisen, H., and Tonegawa, S. (1998). Difference in the level of expression of class I MHC proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection. Proc. Natl. Acad. Sci. USA, 95, 5235-5240.
- Sykulev, Y., Joo, M., Vturina, I., Tsomides, T.J., and Eisen, H.N. (1996). Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response, Immunity, 4, 565-571.
- Sykulev, Y., Cohen, R.J., and Eisen, H.N. (1995). The law of mass action governs antigen-induced cytolytic activity of CD8+ cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA, 92: 11990-11992.
- Kageyama, S., Tsomides, T.J., Sykulev, Y., and Eisen, H.N. (1995). Variations in the number of peptide-class I MHC complexes required to activate cytotoxic T cell responses. J. Immunol., 154: 567-576.
- Sykulev, Y., Brunmark, A., Tsomides, T.J., Kageyama, S., Jackson, M., Peterson, P.A., and Eisen, H.N. (1994). High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA, 91: 14487-14491.
- Sykulev, Y., Brunmark, A., Jackson, M., Cohen, R.J., Peterson, P.A., and Eisen, H.N. (1994). Kinetics and affinity of reactions between an antigen-specific T-cell receptor and peptide-MHC complexes. Immunity, vol. 1: 15-22.
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Individual Expertise profile of
Yuri K. Sykulev, M.D., Ph.D., Copyright © Yuri K. Sykulev, M.D., Ph.D..
Last Updated
by Yuri Sykulev, M.D., Ph.D. : Friday, November 20, 2009 6:55:33 PM
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