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Thomas Jefferson University - David W. Andrews
David W. Andrews

Neurosurgery
Thomas Jefferson University
Jefferson Medical College
Department of Neurosurgery

Professor of Neurosurgery and Vice Chairman for Clinical Services

Associate Training Program Director

Director, Division of Neuro-oncologic Neurosurgery and Stereotactic Radiosurgery

Director, Stereotactic Radiosurgery Units, Jefferson Hospital for Neuroscience
Mailing Address
909 Walnut St., 2nd floor
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-7000
Fax: 215-503-7038
Qualifications
B.S., Biological Science, Stanford University, 1975
B.A., Political Science, Stanford University, 1975
M.S., Political Science, Stanford University, 1977
M.D., University of Colorado, 1983
Expertise and Research Interests
Subspecialization in:

* Surgical and radiosurgical treatment of brain tumors
* Neuro-oncologic neurosurgery with image-guidance and intraoperative motor and speech corticography
* Neuroendoscopic neurosurgery
* Biologically-based treatment of malignant gliomas
* MRI-based stereotactic biopsy
* Conventional fraction stereotactic radiotherapy


Dr. Andrews trained at the New York Hospital-Cornell Medical Center and completed a one year fellowship in Neuro-oncology at the Memorial Sloan-Kettering Cancer Center. At the inception of his academic career, he received a prestigious Physician Scientist Award conferred by the National Cancer Institute to pursue basic research devoted to the molecular biology of gliomas for a 5 year period. His mentor was Dr. Carlo Croce, a member of the National Academy of Science and one of the leading cancer researches in America today.

Drawing from his background in molecular biology, Dr. Andrews was the first physician at Thomas Jefferson University and in the Delaware Valley to participate in a prospective randomized trial involving gene therapy trial for the treatment of glioma which closed in 1999. Dr. Andrews currently serves as Co-Principal Investigator of a unique FDA-approved antisense DNA protocol designed for the treatment of glioma and has thus far successfully treated 12 patients. With this Phase I study still open, he has submitted four additional Phase I through Phase III proposals to the FDA for approval based on the early promising results in the Phase I trial.

Dr Andrews is recognized as a world leader in radiosurgery and established the first Radiosurgery Program in the Delaware Valley in 1991. He has lectured throughout the world as an invited speaker on radiosurgery topics and is noted for techniques in stereotactic radiotherapy which he has pioneered and has described successful treatments of tumors involving or near special sensory nerves such as the optic nerve or cochlear nerve.

Invited Lectures :

* 1993 Hopital Princesa, Madrid, Spain, Inauguration of Radiosurgery in Spain
* 1994 Barcelona, Spain, Inauguration of Radiosurgery in Barcelona (panelist)
* 1994 Madrid, Spain, First Spanish Stereotactic Radiosurgery Congress
* 1994 Philadelphia, PA, the Pan-Philadelphia Neurosurgery Conference
* 1995 Salzburg, Austria, The Cornell-Austrian Seminars in Medicine
* 1995 Mexico City, Mexico, The Neuroscience Institute
* 1995 Gainseville, FL, The Second X-Knife Society Meeting
* 1995 Taipei, Taiwan, the Australo-Asian Neurosurgery Congress
* 1996 The Mayo Clinic, Rochester, MN
* 1996 Paris, France, The French Neurosurgery Congress
* 1996 Philadelphia, PA, The Third X-Knife Society Meeting
* 1997 Madrid, Spain, The Third Biannual International Stereotactic Radiosurgery Society (panelist)
* 1997 Orlando, FL, The Fourth X-Knife Society Meeting
* 1997 San Francisco, CA, Joint AANS-CNS Course on Functional and Stereotactic Neurosurgery (faculty)
* 1998 Bangkok, Thailand, Inauguration of Radiosurgery in Thailand
* 1998 Snowmass, Colorado, The Mayfield Clinic-Cleveland Clinic Winter Neuroscience Symposium (faculty)
* 1999 Sydney, Australia, The Fourth Biannual International Stereotactic Radiosurgery Society (panelist)
* 1999 Allentown, PA, Inauguration and Contintuing Education Course/ Radiosurgery, Lehigh Valley Hospital
* 1999 Barcelona (Sitges), Spain, The Second Spanish Radiosurgery Society (panelist)
* 1999 Milwaukee, WS, Biannual Acoustic Neuroma Association (panelist/lecturer)* 1999 Snowbird, UT, The American Society of Functional and Stereotactic Radiosurgery (panelist)
* 1999 Boston, MA, The Congress of Neurological Surgery (panelist)
* 2000 Snowmass, CO, The Mayfield Clinic-Cleveland Clinic Winter Neuroscience Symposium (faculty)
* 2000 Munich, Germany, Klinicum Grosshaden
* 2000 San Antonio, TX, The Congress of Neurological Surgery (faculty)
* 2000 Sao Paolo, Brazil Radiosurgery Symposium (faculty/ Visiting Professor)

In addition to successfully eliminating tumors, the fractionated stereotactic technique also preserves sight and hearing. He was recently invited to speak before the Acoustic Neuroma Association in Milwaukie to share his experience of fractionated stereotactic radiotherapy with acoustic tumor patients. He is Principal Investigator of a North American prospective radiosurgery randomized trial sponsored by the RTOG and the National Cancer Institute examining patients with brain metastases that has accrued over 300 patients from 60 different participating institutions.

Dr. Andrews is a member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons, the American and World Societies of Functional And Stereotactic Neurosurgery, the International Stereotactic Radiosurgery Society, and the Society of University Neurosurgeons.
Keywords
Neurosurgery; neuro-oncology; radiosurgery; gamma knife; LINAC; brain tumor
Publications
  • Publications (1999- present)

  • Thakur ML, Li JL, Kim Sm, Zhang JJ, and Andrews DW. Targeting tumors with Iodine-123 labeled deoxyuridine: distribution and DNA binding. Cancer Detection and Prevention 23:72-77, 1999

  • Werner-Wasik M, Rudoler S, Preston PE, Downes BM, Andrews DW, Corn B, Rosenstock J, and Curran WJ. Immediate side effects (ISE) of stereotactic radiotherapy and radiosurgery. Int J Radiation Oncol. Biol. Phys. 43:299-304, 1999

  • Hudes, R, Corn B, Werner-Wasik M, Andrews DW, Rosenstock J, Thoron L, Downes B, Curran WJ. A Phase I Dose Escalation Study of Hypofractionated Stereotactic Radiotherapy as Salvage Therapy for Persistent or Recurrent Malignant Glioma. Int. J. Radiation Oncol. Biol. Phys. 43:293-298, 1999

  • Vinitski S, Gonzalez CF, Knobler R, Andrews DW, Iwanaga T, Curtis M. Fast Tissue Segmentation Based on a 4D Feature Map in Characterization of Intracranial Lesions. J Magn Reson Imaging, 9:768-776, 1999

  • Veznedaroglu E., Armonda RA, and Andrews DW. Diagnosis and therapy for pituitary tumors. Current Opinion in Oncology, 11:27-31, 1999

  • Moses RL, Keane WM, Andrews DW, Goel R, Simeone F. Endoscopic transseptal transsphenoidal hypophysectomy with three-dimensional intraoperative localization technology. Laryngoscope, 109:509-512, 1999

  • Kalapurakal JA, Silverman CL, Akhtar CL, Andrews DW, Downes B, and Thomas PRM. Improved trigeminal and facial nerve tolerance following fractionated stereotactic radiotherapy for large acoustic neuromas. British J of Radiology 72:1202-1207, 1999.

  • Kalapurakal JA, Silverman CL, Akhtar CL, Downes B, Andrews DW, Laske DW, and Thomas PRM. Acute hyperthermia following stereotactic radiosurgery for pituitary adenoma. British J of Radiology, 72:1218-1221, 1999

  • Mao V., Keane WM, Atkins JP, Willcox TO, Rosen MR, Andrews DW, Zwillenberg D. Endoscopic Repair of Cerebrospinal Fluid Rhinorrhea. Otolaryngol Head Neck Surg, 122:56-60, 2000.

  • Rainov NG and the GLI328 International Study Group. A phase III clinical evaluation of Herpes Simplex Virus Type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Human Gene Therapy, 11:2389-2401, 2000.

  • Andrews DW, Resnicoff M, Flanders AM, Kenyon L, Curtis M, Merli G, Baserga R, Iliakis G, and Aiken RD. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type-1 receptor in malignant astrocytomas. J Clin Oncology, 19:2189-2200, 2001.

  • Andrews DW, Suarez O, Goldman HW, Downes, B, Bednarz G, Corn BW, Werner-Wasik M, Boulos PT, Rosenstock J, Curran Jr. WJ. Stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of acoustic schwannomas: comparative observations of 125 tumors treated at one institution. Int. J. Radiation Oncol. Biol. Phys, 50:1265-1278, 2001.

  • Buchheit WA and Andrews DW. How should we examine surgical proficiency in neurosurgery? Acta Neurochirg 2001; 149: 149-152.

  • Andrews DW, Faroozan R, Yang BP, Hudes RS, Werner-Wasik M, Kim SM, Sergott RC, Savino P, Shields J, Shields C, Downes B, Simeone FA, Goldman HW, Curran WJ Jr. Fractionated stereotactic radiotherapy for the treatment of optic nerve sheath meningiomas: Preliminary observations of 33 optic nerves in 30 patients with historical comparison to observation with or without prior surgery. Neurosurgery, 51:890-904, 2002.

  • Nau JA, Shields CL, Shields JA, Andrews DW. Optic nerve glioma in a patient with von Hippel-Lindau Syndrome. J of Pediatric Ophthalmology & Strabismus, Vol. 40:57-58, 2003.

  • Cho J, Harrop JE, Veznadaroglu E, Andrews DW. Concomitant use of computer image-guidance, linear/sigmoid incisions after minimal shave, and liquid wound dressing with 2-octylcyanoacrylate for tumor craniotomy/craniectomy: Analysis of 225 consecutive surgical cases with matched historical control. Neurosurgery 52: 832-839 (2003).

  • Bloomer CW, Kenyon L, Hammond E, Hyslop T, Andrews DW, Curran WJ, and Dicker AP Cycloocygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas American Journal of Clinical Oncology 2003; 26: S75-80.

  • Linn CC, Kenyon L, Hyslop T, Hammond E. Andrews DW, Curran WJ, and Dicker AP Cycloocygenase-2 (COX-2) expression in human meningioma as a function of tumor grade. American Journal of Clinical Oncology 2003; 26: S98-102.

  • Febles C, Goldman HW, Werner-Wasik M, Rosenwasser RH, Curran WJ, and Andrews DW A comparison of treatment outcomes with Gamma Knife radiosurgery versus Glycerol rhyzotomy in the management of trigeminal neuralgia Int. J. Radiation Oncol. Biol. Phys 2003; 57:S253.

  • Andrews DW, Scott CE, Sperduto P, Gaspar LE, Schell M, Werner-Wasik M, Demas WR, Ryu JK, Fontanesi J, Rotman M, Mehta M, and Curran WJ. Phase III randomized trial comparing whole brain radiation therapy with or without stereotactic radiosurgery for patients with one to three brain metastases: Results of the RTOG 9508 trial Lancet 2004; 363: 1665-1672.

  • Veznedaroglu E, Andrews DW, Benitez R, Downes B, Bednarz G, Corn BW, Werner-Wasik M, Rosenstock J, Curran Jr. WJ, and Rosenwasser RH. LINAC hypofractionated stereotactic radiotherapy for the treatment of large arteriovenous malformations with or without prior partial embolization. Neurosurgery 2004; 55: 519-531.

  • Spector AR, Artz GJ, Andrews DW, Cunnane MF, Rao VM, Keane WM Metastases of a parotid adenocarcinoma to the pituitary gland: case report. (in press)

  • Behling E, Birbe R, Veznadaroglu E, Andrews DW, Flanders A, and Kenyon LC,

  • Gliosarcoma arising from an anaplastic ependymoma, a case report of a rare

  • entity Human Pathology 2004; 35: 512-516.

  • Chen C, Andrews DW, Hudes RS, Werner-Wasik M, Chervoneva I, Bednarz G, Downes B, Curran WJ. Surgical resection prior to salvage stereotactic radiation therapy in patients with persistent or progressive malignant glioma is associated with extended survival. (submitted)

  • Paek, S-H., Downes MB, Bednarz G, Werner-Wasik M, Curran WJ, and Andrews DW. Integration of surgery with fractionated stereotactic radiotherapy (FSR) for the treatment of patients with nonfunctioning pituitary macroadenomas International Journal of Radiation Oncology Biology Physics 2005; 61(3): 795-808.

  • Tang J, Flomenberg, P, Harshyne L, Kenyon, L, and Andrews, DW Glioblastoma patients exhibit circulating tumor-specific CD8 T cells (submitted)

  • Paek, S-H, Cho J, Sperling M, and Andrews DW. Re-evaluation of surgery for the treatment of brain metastases: Review of 208 patients with single or multiple brain metastases treated at one institution utilizing modern neurosurgical techniques. Neurosurgery, (in revision)

  • Behbehani RS, McElveen T, Curran WJ, Andrews, DW, Sergott RC, and Savino PJ Steeotactic fractionated radiotherapy for parasellar meningiomas: a preliminary report of visual outcomes British J Ophthalmology, (in press)

  • Febles C, Goldman HW, Rosenwasser, RH, Downes, MB, Bednarz G, Werner-Wasik M, Curran WJ, and Andrews, DW Outcome assessments of glycerol rhizotomy v. Gamma Knife radiosurgery utilizing a common pain scale questionnaire for patients with trigeminal neuralgia treated at one institution. International Journal of Radiation Oncology Biology Physics, (in revision)

  • Heron DE, Henderson SL, Downes MB, Bednarz G, Werner-Wasik M, Curran Jr. WJ, and Andrews DW. Fractionated stereotactic radiotherapy for the treatment of craniopharyingioma: Results of treatment in 22 patients. (in preparation.)

  • Andrews DW, Friedman DP, Cho J, Kenyon L, Prozniak M, and Hooper DC Do patients with anaplastic astrocytomas have a better prognosis if their tumors are non-enhancing or well-circumscribed? Retrospective analysis of 46 WHO Grade III cases. Neurosurgery, (in revision)

  • Cifarelli C, Evans JJ, and Andrews DW Neuroendoscopic biopsy of intraventricular tumors: a review of five unusual cases (in preparation).

  • Book Chapters and Invited Articles

  • Andrews DW, Corn BW and Buchheit WA. Conventional radiation and focussed beam radiation for the treatment of acoustic neurinomas. In: Gildenberg P and Tasker R, eds. Textbook of Functional and Stereotactic Neurosurgery. New York, NY; McGraw-Hill Publishers; 1997.

  • Andrews DW. Surveys in Ophthalmology

  • Andrews DW. [Response to] Radiobiological and dosimetric considerations in radiosurgery. In: Pollock BE, ed. The Technique and Evaluation of Contemporary Stereotactic Radiosurgery.

  • Andrews DW and Downes MB. LINAC-based Stereotactic Radiosurgery with the X-Knife Treatment Planning System. In: M. Schulder, ed., Handbook of Stereotactic Neurosurgery. New York, NY; Marcel Dekker; 2003.

  • Sharan AD, Buono L, and Andrews DW. Stereotactic Frames: Technical Considerations. In: M. Schulder, ed., Handbook of Stereotactic Neurosurgery. New York, NY; Marcel Dekker; 2003

  • Harshyne L, Flomenberg P, and Andrews DW Immunotherapy strategies for the treatment of malignant gliomas Frontiers in Molecular Neurosurgery (in press)

Individual Expertise profile of David W. Andrews, Copyright © David W. Andrews.
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