Basic Research Studies > Models
of Intracerebral Hemorrhage
Models of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating condition
that affects people suddenly and without warning. Although
many patients recover, a significant number of patients are
left suffering from cognitive deficits (e.g. impairments
in tasks of short-term and long-term memory, verbal fluency,
orientation, unilateral sensory neglect, visual field defects,
anosognosia, constructional apraxia and motor impersistence).
However, the neurochemical substrates underlying cognitive
deficits following ICH are not well understood. It has been
suggested that alterations in cholinergic neurotransmission
may contribute to the cognitive deficits following ICH. Cholinergic
neurons are enriched in the basal forebrain and send widespread
projections to brain regions involved with learning, memory
and cognitive processing. The impact of ICH on acetylcholine
production and transmission is not known. This research seeks
to answer whether ICH in the region of the ventral pallidum/basal
forebrain results in a significant decrease in cholinergic
cells and transmission.
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