Clinical Research Studies > Neuro-Oncologic Neurosurgery and Stereotactic Radiosurgery

Neuro-Oncologic Neurosurgery and Stereotactic Radiosurgery

	David W, Andrews, MD, FACS Professor and Vice Chairman, Department of Neurosurgery Chief, Division of Neuro-Oncologic Neurosurgery and Stereotactic Radiosurgery Director, Radiosurgery Units, Jefferson Hospital for Neuroscience
	James J Evans, MD Assistant Professor Co-Director, Program for Minimally Invasive Cranial Base Surgery and Endoscopic Neurosurgery
	Larry Harshyne, PhD Instructor

The Division of Neuro-Oncologic Neurosurgery and Stereotactic Radiosurgery is devoted to the care of patients and advancement of knowledge for patients with benign and malignant brain tumors. We are committed to the most effective, often least invasive, and ultimately the most innovative care for these patients. We routinely draw from the latest technological advancements to achieve our outcomes, including the use of stereotactic radiosurgery, fractionated stereotactic radiotherapy, and minimally invasive surgery of the skull base through the use of image-guided neuro-endoscopy. In a nationwide survey of 607 hospitals performed by the American College of Surgeons, Jefferson was the leading institution in the treatment of primary brain tumors.

Clinical Studies in Stereotactic Radiosurgery/ Fractionated Stereotactic Radiotherapy

• Prospective archival glioma patient database including parallel clinical, radiographic, histopathological and unsupervised and supervised microarray analyses.   PI: D. Andrews. COIs: J. Evans, W. Curran, L. Harshyne, J. Mason, M. Curtis, A. Flanders.

• In vitro study to determine the capacity of glioma cells and metastatic intracranial tumor cells to cross-prime dendritic cells and induce a measurable antitumor cytotoxic t-cell response. PI: D. Andrews. COIs: D. Hooper, L. Harshyne, P. Flomenberg.

• Overall experience of pituitary tumor patients at Thomas Jefferson University   PI: J. Evans.COIs: D. Cognetti, G. Toshkezi, J. Curry, M. Maltenfort, M. Rosen.

• Growth of the cranial base program: Neurosurgery/Otolaryngology experience  PI: J. Evans.  COIs: D. Cognetti, G. Toshkezi, J. Curry, M. Maltenfort, M. Rosen.

• Surgical treatment of pituitary tumor: Transition from open to endoscopic approach. PI: J. Evans.  COIs: D. Cognetti, G. Toshkezi, J. Curry, M. Maltenfort, M. Rosen, H. Singh, S. Falowski.

• A retrospective review of the radiographic and prognostic qualities of anaplastic astrocytoma subtypes.   PI: D. Andrews.  COI: H. Moulding.