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Thomas Jefferson University - Emmanuel Besa
Emmanuel Besa

Medical Oncology
Hematologic Malignancies
Thomas Jefferson University
Jefferson Medical College
Kimmel Cancer Center, Division of Neoplastic Diseases
Professor of Medicine
Appointed: 2005
Mailing Address
801 Sheridan Bldg. 125 So. 9th St
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-3781
Fax: 215-955-9641
emmanuel.besa@jefferson.edu
Expertise and Research Interests
Specializes in clinical trials in hematologic malignancies and myelodysplastic syndromes. Awarded MDS Center of Excellence by the Myelodysplastic Syndromes Foundation.
Other Expertise
Special interest is Medical Informatics, developing educational materials on the Web such as Teaching Cases for American Society of Hematology, Chief Editor of Hematology for on line Medical Text in eMedicine.
Industrial Relevance
Special consultant to Pharmaceutical Companies for drug development.
Keywords
Clinical trials; hematologic malignancies; myelodysplastic syndromes; lymphomas; multiple myeloma; acute and chronic leukemias; myeloproliferative diseases; polycythemia vera; essential thrombocythemia; agnogenic myeloid metaplasia; primary myelofibrosis.
Languages
English, Tagalog (Filipino)
Publications
  • Hait WN, Gorshein D, Jepson JH, Besa EC, Gardner FH. 19-nortestostrone decanoate nduced erythropoiesis in the actinomycin-D-treated hyperoxic mouse. Biochemical and Biophysical Research Communications 47: 426-431, 1972.

  • Besa EC, Gorshein D, Hait WA, Gardner FH. Effective erythropoiesis induced by 5²-pregnane-3²-hydroxy-20-one in squirrel monkeys. Journal of Clinical Investigation 52: 2278-2282, 1973.

  • Gorshein D, Hait WN, Besa EC, Jepson JH, Gardner FH. Increased stem cell response to erythropoietin induced by androgens. Endocrinology 93: 777-780, 1973

  • Hait WN, Gorshein D, Besa EC, Jepson JH, Gardner FH. The effect of steroid metabolites on the hematopoietic stem cell pool. Journal of Pharmacology and Experimental Therapeutics 186: 656-661, 1973.

  • Fishman DR, Leonard RA, Gorshein D, Besa EC, Jepson JH, Gardner FH. Stem cell damage induced by hyperoxia. Biomedicine 19: 291-295, 1973.

  • Leonard RA, Jepson JH, Hait WN, Gorshein D, Besa EC, Gardner FH. Enhanced erythropoietic response in steroid-treated mice. Transactions of the Association of American Physicians 86: 167-177, 1973.

  • Gorshein D, Hait WN, Besa EC, Jepson JH, Gardner FH. Rapid stem cell differentiation induced by 19-nortestosterone decanoate. British Journal of Haematology 26: 215-225, 1974.

  • Besa EC, Gorshein D, Gardner FH. Androgens and human blood volume changes. Comparison in normal and various anemic states. Archives of Internal Medicine 133: 418-425, 1974.

  • Norris A, Gorshein D, Besa EC, Leonard RA, Gardner FH. Stimulation and suppression of erythropoiesis in the plethoric mouse by cyclic nucleotides. Proceedings for the Society for Experimental Biology and Medicine 145: 975-978, 1974.

  • Jepson JH, Leonard RA, Gorshein D, Gardner FH, Besa EC. Review of the induction of cycling of erythropoietin sensitive cells by androgens and their 5²-H metabolites. Biomedicine 20: 262-266, 1974.

  • Pollock TW, Besa EC, Gindea AJ, Rosato EF, Miller LD. Role of chronically decreased oxygen-hemoglobin affinity in the control of red cell production. Surgical Forum 26: 88-89, 1975.

  • Gardner FH, Besa EC. The onset of a refractory response to androgens in the anemia of bone marrow failure. Transactions of the American Clinical & Climatological Association 88: 108-118, 1976.

  • Besa EC, Dale DC, Wolff SM, Gardner FH. Etiocholanolone and prednisolone therapy in patients with severe bone marrow failure. Lancet 1: 728-730, 1977.

  • Ray PK, Besa EC, Idiculla A, Rhoades JE, Jr., Bassett JG, Cooper DR. Efficient removal of abnormal immunoglobulin G from the plasma of a patient with multiple myeloma. Description of a new method for the treatment of the hyperviscosity syndrome. Cancer 45: 2633-2638, 1980.

  • Ray PK, Idiculla A, Rhoades JE, Jr., Besa EC, Bassett JG, Cooper DR. Immunoadsorption of IgG molecules from the plasma of multiple myeloma and autoimmune hemolytic anemia patients. Proceedings of the Haemonetics Research Institute for Advances in Component Seminar. Boston, MA 1979. Journal of Plasma Therapy 1: 33, 1980.

  • Lane SD, Besa EC, Joseph RR. Tamoxiphen and hypercalcemia. Annals of Internal Medicine 92: 514, 1980.

  • Lane SD, Besa EC, Justh G, Joseph RR. Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocytic leukemia. Cancer 47:32-36, 1981.

  • Nowell PC, Shankey V, Finan J, Besa EC. Proliferation, differentiation and cytogenetics of chronic leukemic B lymphocytes cultured with mitomycin-treated normal cells. Blood 57: 444-451, 1981.

  • Besa EC, Bullock LP. The role of the androgen receptor in erythropoiesis. Endocrinology 109: 1983-1989, 1981.

  • Besa EC, Ray PK, Swami VK, Idiculla A, Rhoades JE, Jr., Bassett JG, Cooper DR. Specific immunoadsorption of IgG antibody in a patient with chronic lymphocytic leukemia and autoimmune hemolytic anemia. A new form of therapy for the acute critical stage. American Journal of Medicine 71:1035-1040, 1981.

  • Besa EC, Nowell PC, Geller NL, Gardner FH. Analysis of the androgen response of 23 patients with agnogenic myeloid metaplasia. The value of chromosomal studies in predicitng response and survival. Cancer 49: 308-313, 1982.

  • Knight T, Besa EC, Joseph RR, Baskin SJ. Effect of intermittent and continuous administration of l-cysteine hydochloride on L1210 mouse leukemia. Cancer Treatment Reports 67: 318-319, 1983.

  • Wakayama K, Besa EC, Baskin SJ. Changes in intracellular taurine content of human leukemic cells. Nagoya Journal of Medical Sciences 45: 89-96, 1983.

  • Nowell PC, Besa EC, Emanuel B, Pathak S, Finan J. Two adult siblings with thrombocytopenia and a familial 13:14 translocation. Cancer Genetics and Cytogenetics 11: 169-174, 1984.

  • Besa EC. Use of intravenous immunoglobulins in chronic lymphocytic leukemia. American Journal of Medicine 76(3A): 209-218, 1984.

  • Nowell P, Bergman G, Besa EC, Wilmoth D, Emanuel B. Progressive preleukemia with a chromosomally abnormal clone in a kindred with the Estren-Dameshek variant of Fanconi's anemia. Blood 64: 1135-1158, 1984.

  • Mangan KF, Besa EC, Shadduck RK, Tedrow H, Ray PK. Demonstration of two distinct antibodies in autoimmune hemolytic anemia with reticulocytopenia and red cell aplasia.

  • Experimental Hematology 12: 788-793, 1984.

  • Wakayama K, Besa EC, Baskin SJ. Two components in L1210 cells and their growth characterization. Nagoya Journal of Medical Sciences 46: 125-142, 1984.

  • Feder M, Finan J, Besa EC, Nowell PC. A 2p;11q chromosomal translocation in dysmyelopoietic preleukemia. Cancer Genetics and Cytogenetics 15: 143-150, 1985.

  • Besa EC, MacNab MW, Solan AJ, Lapes MJ, Marfatia U. High dose intravenous IgG in the treatment of pregnancy in women with idiopathic thrombocytopenic purpura. American Journal of Hematology 18: 373-379, 1985.

  • Abrahm J, Besa EC, Hyzinski M, Finan J, Nowell PC. Disappearance of cytogenetic abnormalities and clinical remission during therapy with 13-cis retinoic acid in a patient with myelodysplastic syndrome; inhibition of growth of the patient's monocytoid clone. Blood 67: 1323-1327, 1986.

  • Silberstein LE, Robertson GA, Hannam-Harris AG, Moreau L, Besa EC, Nowell PC. Etiologic aspects of cold agglutinin disease: Evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an Anti Pr cold autoantibody is derived from a chromosomally aberrant B-cell clone. Blood 67: 1705-1709, 1986.

  • Nowell PC, Vonderheid EC, Besa EC, Hoxie JA, Moreau L, Finan JB. The most common chromosome change in 86 chronic B cell or T cell tumors: A 14q 32 translocation. Cancer Genetics and Cytogenetics 19: 219-227, 1986.

  • Nowell PC, Besa EC, Stelmach T, Finan JB. Chromosome studies in preleukemic states. V. Prognostic significance of single versus multiple abnormalities. Cancer 58: 2571-2575, 1986.

  • Kagan J, Finan J, Letofsky J, Besa EC, Nowell PC. ±-Chain locus of the T-cell antigen receptor is involved in the t(10;14) chromosome translocation of the T-cell acute lymphocytic leukemia. Proc Natl Acad Sci USA 84: 4543-4546, 1987.

  • Besa EC. Approach to mild anemia in the elderly. Clinics in Geriatric Medicine 4: 43-55, 1988.

  • Koeffler HP, Heitjan D, Mertelsmann R, Kolitz JE, Schulman P, Itri L, Gunter P, Besa EC. Randomized study of 13- cis Retinoic acid v placebo in the myelodysplastic disorders. Blood 71: 703- 708, 1988.

  • Besa EC. Rapid transient reversal of anemia and long term effects of maintenance intravenous immunoglobulin for autoimmune hemolytic anemia in patients with lymphoproliferative disorders. American Journal of Medicine 84: 691-698, 1988.

  • Moore JS, Prystowsky MB, Hoover RG, Besa EC, Nowell PC. Defective T cell-mediated, isotype-specific immunoglobulin regulation in B cell chronic lymphocytic leukemia. Blood 71:1012-1020, 1988.

  • Nowell PC, Moreau L, Growney P, Besa EC. Karyotypic stability in chronic B cell leukemia. Cancer Genetics and Cytogenetics 33: 155-160, 1988.

  • Nowell PC, Besa EC. Prognostic significance of single chromosome abnormalities in preleukemic states. Cancer Genet Cytogenet 42: 1-7, 1989.

  • Huebner K, Nagarajan L, Besa EC, Angert E, Lange BJ, Cannizzaro LA, van den Berghe H, Santolli D, Finan J, Croce CM, Nowell PC. Order of Genes on Human Chromosome 5q with Respect to 5q Interstitial Deletions. Am J Hum Genet 46:26-36, 1990.

  • Kagan J, Finger LR, Besa E, Croce CM. Detection of minimal residual disease in leukemic patients with the t(10;14)(q24;q11) chromosomal translocation. Cancer Research 50:5240-5244, 1990.

  • Goldberg H, Lusk E, Moore J, Nowell PC, Besa EC. Survey of exposure to known and potential genotoxins in primary myelodysplastic syndrome: Correlation with chromosome patterns and data on patients without hematologic disease. Cancer Research, 50:6876-6881, 1990.

  • Besa EC, Abrahm JL, Bartholomew MJ, Hyzinsky M, Nowell PC. Treatment with 13-cis retinoic acid of transfusion-dependent patients with myelodysplastic syndrome and decreased toxicity with addition of alpha-tocopherol. Am J Med, 89: 739-747, 1990.

  • Friedman DF, Cho AE, Goldman J, Carmack CE, Besa EC, Hardy RR, Silberstein LE. The role of clonal selection in the pathogenesis of autoreactive human B cell lymphoma. J Exp Med 174:525-537, 1991.

  • Besa EC: Recent advances in the treatment of chronic lymphocytic leukemia: Defining the role of intravenous immunoglobulin. Seminars in Hematology 29: Suppl 2: 14-23, 1992.

  • Besa EC: Myelodysplastic syndromes (Refractory anemia): A perspective of the biologic, clinical, and therapeutic issues. The Medical Clinics of North America 76:599-617, 1992

  • Tuszynski GP, Smith M, Rothman VL, Capuzzi DM, Joseph RR, Katz J, Besa EC, Treat J, Switalska HI. Thrombospondin levels in patients with malignancy. Thrombosis and Haemostasis:67:607-610, 1992.

  • Zeigler ZR, Rosenfeld CS, Nemunaitis JJ, Besa EC, Shadduck RK. Increased macrophage colony stimulating factor levels in immune thrombocytopenic purpura. Blood 81:1251-1254, 1993.

  • Nowell PC, Moore JS, Fox FE, Capocasale RJ, Kant JA, Besa EC. Richters syndrome associated with loss of response to transforming growth factor-beta. Leukemia Research 18:85-89, 1994.

  • Besa EC. Hematologic effects of androgens revisited: An alternative therapy in various hematologic conditions. Seminars in Hematology 31:134-146, 1994.

  • Nathan FE, Herman JH, Keashen-Schnell M, McFarland JG, Besa EC, Hadley C, Catalano PM. Anti-BAK neonatal alloimmune thrombocytopenia: Possible prevention by intravenous immunoglobulin. Pediatric Hematology and Oncology, 11:325-329, 1994.

  • Moore JS, Friedman DF, Silberstein LE, Besa EC, Nowell PC. Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia. Critical Reviews in Oncology/Hematology. 20:141-164, 1995.

  • Besa EC, Nieman LZ, Joseph RR. Interactive computer-based programs for a cancer learning center. Journal of Cancer Education 10:137-140, 1995.

  • Zeigler ZR, Rosenfeld CS, Andrews III DF, Nemunaitis J, Raymond JM, Shadduck RK, Kramer RE, Gryn JF, Rintels PB, Besa EC, George JN. Plasma vonWillebrand factor vWF:AG) and thrombomodulin (TM) levels in adult thrombotic thrombocytopenic purpura/Hemolytic uremic syndrome (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM). Am J Hematology 53:213-229, 1996.

  • Besa, EC. Myelodysplastic syndromes: Recent advances in the biology and therapy of this complex disease. Cancer Therapeutics 1:52-63, 1998.

  • Besa, EC, Kunselman S, Nowell PC and the Central Pennsylvania Oncology Group. A pilot trial of 13-cis-retinoic acid and apha-tocopherol with recombinant human erythropoietin in myelodysplatic syndrome patients with progressive or transfusion-dependent anemias. Leukemia Research 22:741-749, 1998.

  • Anthony MT, Zeigler ZR, Lister J, Raymond JM, Shadduck RK, Kramer RE, Gryn JF, Rintels PB, Besa EC, George JN, Silver B, Joyce R, and Bodensteiner D. Plasminogen activator inhibitor (PAI-1) antigen levels in primary TTP and secondary TTP post-bone marrow transplantation. Am J Hematol 59:9-14, 1998.

  • Besa, EC, Kim, PW and Haurani, FI. Treatment of the primary defective iron reutilization syndrome: Revisited. Ann Hematol 79: 465-468, 2000.

  • Zeigler ZR, Shadduck RK, Gryn JF, Rintels PB, George JN, Besa EC, Bodensteiner D, Silver B, Kramer RE: Cryoprecipitate poor plasma does not improve early response in primary adult thrombotic thrombocytopenic purpura (TTP).J Clin Apheresis. 16(1):19-22, 2001.

  • Kumar A, Kulkarni R, Besa EC.: Metastasis of an esophageal carcinoma to the soft tissue in the elbow. Oncology Spectrums: 1:382-383, 2001.

  • Kulkarni R, Kumar A, Besa EC: Unusually prolonged complete remission with fludarabine and cyclophosphamide followed by Rituximab in refractory, previously treated, CLLa case report. Oncology Spectrums: 2:610-611, 2001.

Individual Expertise profile of Emmanuel Besa, Copyright © Emmanuel Besa.
Last Updated by Rodney Murray : Monday, January 8, 2007 1:51:39 PM



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