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Thomas Jefferson University - Emanuel Rubin, M.D.
Emanuel Rubin, M.D.

Pathology, Anatomy and Cell Biology
Thomas Jefferson University
Jefferson Medical College
Department of Pathology
Anatomy & Cell Biology
Gonzalo E. Aponte Professor Appointed: 1986

Mailing Address

Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-5733
Emanuel.Rubin@jefferson.edu
Qualifications
B.S., Villanova University, 1950

M.D., Harvard Medical School, 1954

Diplomate, Board Certification, American Board of Pathology

Other Expertise

CURRENT HOSPITAL APPOINTMENTS
Thomas Jefferson University Hospital, Philadelphia, PA,
Attending Physician-in-Chief (Pathology) 1986-present.

CURRENT CONSULTANTSHIPS
Medical Advisory Council, Alcoholic Beverage Medical Research Foundation 1992-.

EDITORIAL POSITIONS
EDITOR-IN-CHIEF: Laboratory Investigation 1982-1995;
FIELD EDITOR (PATHOLOGY): Quarterly Journal of Studies in Alcohol, Federation Proceedings, FASEB Journal;
ASSISTANT EDITOR: Addiction Biology;
EDITORIAL BOARDS: Laboratory Investigation, Human Pathology, Gastroenterology, American Journal of Alcohol and Drug Abuse, Substance and Alcohol Abuse, Medicine and Chirurgie Digestives, Alcohol and Alcoholism, Alcohol Health and Research World, Addiction Biology;
REVIEWING EDITOR: Alcoholism: Clinical and Experimental Research.
Keywords
Pathology
Publications
  • Solem, M., Almas, J., Rubin, E. and Thomas, A. Changes in Activity and Regulation of the Cardiac Ca2+ Channel (L-type) by Protein Kinase C in Chronic Alcohol-Exposed Rats. Alcoholism, Clinical and Experimental Research. 24(8): 1145-1152, 2000

  • Ponnappa, B.C., Rubin, E. Modeling Alcohol's Effects on Organs in Animal Models. Alcohol Research and Health. 24(2): 93-104, 2000

  • Fenderson, B.A., Damjanov, I., Rubin, E. PATHOLOGY Q&A [CD-ROM]. Thomas Jefferson University, Philadelphia, Pa. , 2000

  • Bokkala S, Rubin E, Joseph SK. Effect of chronic ethanol exposure on inositol trisphosphate receptors in WB rat liver epithelial cells. Alcoholism, Clinical and Experimental Research. 23(12): 1875-83, Dec 1999

  • Fenderson BA, Hojat M, Damjanov I, Rubin E. Characteristics of medical students completing an honors program in pathology. Human Pathology. 30(11): 1296-301, Nov 1999

  • Fenderson, B.A., Damjanov, I., Maxwell, K., Veloski, J.J., Rubin, E. Teaching and Evaluation: Based on Keywords and Extended Matching Questions. Pathology Education. 24(1): 17-29, 1999

  • Hoek, J.B. and Rubin, E. Intracellular signal transduction in liver regeneration. In: Liver Growth and Repair. (Strain, A. and Diehl, A.M. eds) Chapter 14, Thompson Science Publishers, London, UK. 366-401, 1999

  • Mutti, L., Giuseppe, C., Giordano, A., Rubin, E. Carcinogenic Effect of Simian Virus 40 and Asbestos Fibers on Rb Family Proteins and Cell Cycle Machinery of malignant Mesothelioma Cells. In: Sourcebook on Asbestos Disease, Peters, G.A. and Peters, B.J., Eds., California, LEXIS Law Publishing. 19: 361- 394, 1999

  • Fenderson, B.A., Damjanov, I., Rubin, E., Eds. PATHOLOGY Q&A. Thomas Jefferson University, Philadelphia, PA. , 1998

  • Rubin, E. and Farber, J.L., Eds. PATHOLOGY. Lippincott-Raven Co., Philadelphia, Pa. Third Edition, 1998

  • Fenderson BA, Damjanov I, Robeson MR, Rubin E. Relationship of students' perceptions of faculty to scholastic achievement: are popular instructors better educators? [see comments]. Human Pathology. 28(5): 522-5, May 1997

  • Fenderson BA, Damjanov I, Robeson MR, Veloski JJ, Rubin E. The virtues of extended matching and uncued tests as alternatives to multiple choice questions. Human Pathology. 28(5): 526-32, May 1997

  • Damjanov, I., Fendersaon B.A., Rubin, E. Eds. PATHOLOGY STUDY GUIDE: Learning Objectives with Short Answers. Thomas Jefferson University, Philadelphia, PA. , 1997

  • Nicolas JM, Rubin E, Thomas AP. Ethanol and cocaine cause additive inhibitory effects on the calcium transients and contraction in single cardiomyocytes. Alcoholism, Clinical and Experimental Research. 20(6): 1077-82, Sep 1996

  • Channareddy S, Jose SS, Eryomin VA, Rubin E, Taraschi TF, Janes N. Saturable ethanol binding in rat liver microsomes. Journal of Biological Chemistry. 271(30): 17625-8, Jul 1996

  • Rubin E. The questionable link between alcohol intake and cancer. Clinica Chimica Acta. 246(1-2): 143-8, Mar 1996

  • Israel, Y and Rubin, E. Alcohol-Induced Liver Injury. In: Drug-Induced Hepatotoxicity. Cameron, R.G., Feuer G., de la Iglesia F., eds., Handbook of Experimental Pharmacology: Springer Berlin, 1996. 21: 611-628, 1996

  • Rubin, E. and Urbano-Marquez, A. Clinical Effects of Alcohol on the Cardiovascular System. In: NIAAA Research Monograph, Zakhari, S. and Wassef M., eds., NIH, Bethesda, MD. 31: 127-136, 1996

  • Rubin, E. Alcoholic Liver Disease: New Perspectives. Adv. In Path. Lab. Med., Mosby Yearbook, St. Louis, MO. 9: 393-413, 1996

  • Nalpas B, Feitelson M, Brechot C, Rubin E. Alcohol, hepatotropic viruses, and hepatocellular carcinoma [editorial]. Alcoholism, Clinical and Experimental Research. 19(5): 1089-95, Oct 1995

  • Estruch R, Fernandez-Sola J, Sacanella E, Pare C, Rubin E, Urbano-Marquez A. Relationship between cardiomyopathy and liver disease in chronic alcoholism. Hepatology. 22(2): 532-8, Aug 1995

  • Urbano-Marquez A, Estruch R, Fernandez-Sola J, Nicolas JM, Pare JC, Rubin E. The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. Jama. 274(2): 149-54, Jul 1995

  • Damjanov I, Fenderson BA, Veloski JJ, Rubin E. Testing of medical students with open-ended, uncued questions. Human Pathology. 26(4): 362-5, Apr 1995

  • Rubin, E. Alcohol Abuse. In: Pathology of Environmental and Occupational Disease. J.E. Craighead, Ed., Mosby Year Book. , 1995

  • Rubin, E. Drug tolerance in biomembranes: Commentary for 25th anniversary of NIAAA. Alcohol Health and Research World. 19: 46-47, 1995

  • Rubin, E. and Farber, J.L., Eds. ESSENTIAL PATHOLOGY. J.B. Lippincott Co., Philadelphia, Pa. Second Edition, 1995

  • Fernandez-Sola J, Estruch R, Grau JM, Pare JC, Rubin E, Urbano-Marquez A. The relation of alcoholic myopathy to cardiomyopathy. Annals of Internal Medicine. 120(7): 529-36, Apr 1994

  • Slater SJ, Kelly MB, Taddeo FJ, Ho C, Rubin E, Stubbs CD. The modulation of protein kinase C activity by membrane lipid bilayer structure. Journal of Biological Chemistry. 269(7): 4866-71, Feb 1994

  • Rubin E, Urbano-Marquez A. Alcoholic cardiomyopathy. Alcoholism, Clinical and Experimental Research. 18(1): 111-4, Feb 1994

  • Thomas AP, Rozanski DJ, Renard DC, Rubin E. Effects of ethanol on the contractile function of the heart: a review. Alcoholism, Clinical and Experimental Research. 18(1): 121-31, Feb 1994

  • Victorov, A.V., Janes, N., Moehren, G., Rubin, E., Taraschi, T.F. and Hoek, J.B. Rapid transbilayer movement of phosphatidylethanol in unilamellar phosphatidylcholine vesicles. Journal of the American Chemical Society. 116: 4050-4052, 1994

  • Rubin, E. and Farber, J.L., Eds. PATHOLOGY. J.B. Lippincott Co., Philadelphia, PA. Second Edition, 1994

  • Damjanov, I. and Rubin, E. REVIEW OF PATHOLOGY. J.B. Lippincott Co., Philadelphia, PA. , 1994

  • Ponnappa BC, Dodge GR, Dudkowski B, Hoek JB, Iozzo RV, Rubin E. Stimulation of protein synthesis in isolated pancreatic acini from chronically ethanol-fed rats is due to alterations in post-transcriptional regulation. Biochimica Et Biophysica Acta. 1158(2): 113-9, Oct 1993

  • Slater SJ, Cox KJ, Lombardi JV, Ho C, Kelly MB, Rubin E, Stubbs CD. Inhibition of protein kinase C by alcohols and anaesthetics. Nature. 364(6432): 82-4, Jul 1993

  • Wang DC, Taraschi TF, Rubin E, Janes N. Configurational entropy is the driving force of ethanol action on membrane architecture. Biochimica Et Biophysica Acta. 1145(1): 141-8, Jan 1993

  • Stubbs, C.D. and Rubin, E. Molecular Mechanisms of Ethanol and Anesthetic Actions: Lipid- and Protein-Based Theories. In: Alcohol, Cell Membranes, and Signal Transduction in Brain. C. Alling, et al., Eds., Plenum Press, New York. 1-11, 1993

  • Rubin, E. The chemical pathogenesis of alcohol-induced tissue injury. Alcohol Health and Research World. 17(4): 272-278, 1993

  • Janes N, Hsu JW, Rubin E, Taraschi TF. Nature of alcohol and anesthetic action on cooperative membrane equilibria. Biochemistry. 31(39): 9467-72, Oct 1992

  • Cardellach F, Galofre J, Grau JM, Casademont J, Hoek JB, Rubin E, Urbano-Marquez A. Oxidative metabolism in muscle mitochondria from patients with chronic alcoholism. Annals of Neurology. 31(5): 515-8, May 1992

  • Hoek JB, Thomas AP, Rooney TA, Higashi K, Rubin E. Ethanol and signal transduction in the liver. Faseb Journal. 6(7): 2386-96, Apr 1992

  • Rubin, E. and Thomas, A. P. Alcohol Effects on the Heart and Cardiovascular System. In: Medical Diagnosis and Treatment of Alcoholism, Third Edition, J. Mendelson, Ed., McGraw Hill, New York. 263-287, 1992

  • Stubbs CD, Kisielewski AE, Rubin E. Chronic ethanol ingestion modifies liver microsomal phosphatidylserine inducing resistance to hydrolysis by exogenous phospholipase A2. Biochimica Et Biophysica Acta. 1070(2): 349-54, Dec 1991

  • Cardellach F, Taraschi TF, Ellingson JS, Stubbs CD, Rubin E, Hoek JB. Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment. Biochemical Journal. 274 ( Pt 2): 565-73, Mar 1991

  • Ellingson JS, Janes N, Taraschi TF, Rubin E. The effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositol in rat liver microsomes as determined by gas chromatography and 1H-NMR. Biochimica Et Biophysica Acta. 1062(2): 199-205, Feb 1991

  • Stewart G, Rubin E, Thomas AP. Inhibition by cocaine of excitation-contraction coupling in isolated cardiomyocytes. American Journal of Physiology. 260(1 Pt 2): H50-7, Jan 1991

  • Taraschi TF, Ellingson JS, Janes N, Rubin E. The role of anionic phospholipids in membrane adaptation to ethanol. Alcohol and Alcoholism. Supplement. 1: 241-5, 1991

  • Frank ED, Honet J, Torjman M, Janes N, Rubin E, Barber M, Taraschi T. Effects of chronic exposure to nitrous oxide on membrane fluidity in rats. Annals of the New York Academy of Sciences. 625: 545-7, 1991

  • Taraschi TF, Lee YC, Janes N, Rubin E. Anesthetic potency and conformational stability in membranes. Annals of the New York Academy of Sciences. 625: 698-706, 1991

  • Rubin, E., Miller, K.W. and Roth, S.H., Eds. MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS. Annals of the New York Academy of Sciences. 625, 1991

  • Ponnappa BC, Hoek JB, Jubinski L, Rubin E. Ethanol withdrawal stimulates protein synthesis in rat pancreatic lobules. Biochimica Et Biophysica Acta. 1036(2): 107-12, Nov 1990

  • Hoek JB, Taraschi TF, Higashi K, Rubin E, Thomas AP. Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding. Biochemical Journal. 272(1): 59-64, Nov 1990

  • Rubin E, Farber JL. Environmental diseases of the digestive system. Medical Clinics of North America. 74(2): 413-24, Mar 1990

  • Taraschi TF, Ellingson JS, Wu-Sun A, Rubin E. Rats withdrawn from ethanol rapidly re-acquire membrane tolerance after resumption of ethanol feeding. Biochimica Et Biophysica Acta. 1021(1): 51-5, Jan 1990

  • Hoek JB, Rubin E. Alcohol and membrane-associated signal transduction. Alcohol and Alcoholism. 25(2-3): 143-56, 1990

  • Rubin, E. and Doria, J. Alcoholic cardiomyopathy. Alcohol Health and Research World. 14(4): 277-284, 1990

  • Damjanov, I. and Rubin, E. PATHOLOGY A Study Guide. J.B. Lippincott Co., Philadelphia, PA. , 1990

  • Rubin, E. and Farber, J.L., Eds. ESSENTIAL PATHOLOGY. J.B. Lippincott Co., Philadelphia, PA. , 1990

  • Stubbs CD, Williams BW, Boni LT, Hoek JB, Taraschi TF, Rubin E. On the use of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine in the study of lipid polymorphism. Biochimica Et Biophysica Acta. 986(1): 89-96, Nov 1989

  • Thomas AP, Sass EJ, Tun-Kirchmann TT, Rubin E. Ethanol inhibits electrically-induced calcium transients in isolated rat cardiac myocytes. Journal of Molecular and Cellular Cardiology. 21(6): 555-65, Jun 1989

  • Rooney TA, Hager R, Rubin E, Thomas AP. Short chain alcohols activate guanine nucleotide-dependent phosphoinositidase C in turkey erythrocyte membranes. Journal of Biological Chemistry. 264(12): 6817-22, Apr 1989

  • Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L, Rubin E. The effects of alcoholism on skeletal and cardiac muscle [see comments]. New England Journal of Medicine. 320(7): 409-15, Feb 1989

  • Hoek JB, Ponnappa BC, Rubin E. Dietary carbohydrates and chronic ethanol both affect rat pancreatic amylase levels [letter]. Journal of Laboratory and Clinical Medicine. 113(2): 248-9, Feb 1989

  • Nie Y, Stubbs CD, Williams BW, Rubin E. Ethanol causes decreased partitioning into biological membranes without changes in lipid order. Archives of Biochemistry and Biophysics. 268(1): 349-59, Jan 1989

  • Rubin, E. How alcohol damages the body. Alcohol Health and Research World. 13: 322-327, 1989

  • Rubin, E. and Damjanov, I., Eds. PATHOLOGY REVIEWS 1989. Humana Press, Clifton, N.J. , 1989

  • Ponnappa BC, Hoek JB, Jubinski L, Rubin E. Effect of chronic ethanol ingestion on pancreatic protein synthesis. Biochimica Et Biophysica Acta. 966(3): 390-402, Sep 1988

  • Dorio RJ, Hoek JB, Rubin E, Forman HJ. Ethanol modulation of rat alveolar macrophage superoxide production. Biochemical Pharmacology. 37(18): 3528-31, Sep 1988

  • Stubbs CD, Williams BW, Pryor CL, Rubin E. Ethanol-induced modifications to membrane lipid structure: effect on phospholipase A2-membrane interactions. Archives of Biochemistry and Biophysics. 262(2): 560-73, May 1988

  • Ellingson JS, Taraschi TF, Wu A, Zimmerman R, Rubin E. Cardiolipin from ethanol-fed rats confers tolerance to ethanol in liver mitochondrial membranes. Proceedings of the National Academy of Sciences (USA). 85(10): 3353-7, May 1988

  • Hoek JB, Taraschi TF, Rubin E. Functional implications of the interaction of ethanol with biologic membranes: actions of ethanol on hormonal signal transduction systems. Seminars in Liver Disease. 8(1): 36-46, Feb 1988

  • Hoek, J.B., Taraschi, T.F. and Rubin, E. Functional implications of the interaction of ethanol with biologic membranes. Actions of ethanol on hormonal signal transduction systems. Seminars in Liver Disease. 8: 36-46, 1988

  • Taraschi, T.F., Ellingson, J. S. and Rubin, E. Mechanism of Ethanol Action on Biological Membranes. . In Alcoholism: Origins and Outcome, Rose, R. M. and Barrett, J., Raven Press, New York. 221-228, 1988

  • Rubin, E. and Farber, J.L., Eds. PATHOLOGY. J.B. Lippincott Co., Philadelphia, Pa. , 1988

  • Ponnappa BC, Hoek JB, Waring AJ, Rubin E. Effect of ethanol on amylase secretion and cellular calcium homeostasis in pancreatic acini from normal and ethanol-fed rats. Biochemical Pharmacology. 36(1): 69-79, Jan 1987

  • Hoek JB, Thomas AP, Rubin R, Rubin E. Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes. Journal of Biological Chemistry. 262(2): 682-91, Jan 1987

  • Taraschi TF, Ellingson JS, Rubin E. Membrane structural alterations caused by chronic ethanol consumption: the molecular basis of membrane tolerance. Annals of the New York Academy of Sciences. 492: 171-80, 1987

  • Taraschi, T.F. and Rubin, E. The interaction of ethanol with biological membranes: An overview. In: Pathogenesis of Liver Diseases. Farber, E., Phillips, M. J. and Kaufman, N., Eds., Internat. Acad. Path. Monograph., Baltimore, Williams & Wilkins. 113-135, 1987

  • Pryor, C.L., Stubbs, C.D. and Rubin, E. Phospholipase activity is enhanced in liver microsomes from chronic alcoholic rats. In: Alcohol and the Cell. Rubin, E., Ed, Ann. NY Acad. Sci. 492: 207-209, 1987

  • Nie, Y., Stubbs, C.D. and Rubin, E. Chronic ethanol ingestion decreases the partitioning of hydrophobic molecules into cell membranes due to an alteration in the phospholipids. In: Alcohol and the Cell. Rubin, E., Ed., Ann. NY Acad. Sci. 492: 210-211, 1987

  • Thomas, A.P., Hoek, J.B. and Rubin, E. Elevation of inositol 1,4,5-trisphosphate levels after acute ethanol treatment of rat hepatocytes. In: Alcohol and the Cell, Rubin, E., Ed., Ann. NY Acad. Sci. 492: 250-252, 1987

  • Dorio, R.J., Hoek, J.B., Forman, H.J. and Rubin, E. The effect of ethanol on superoxide production in alveolar macrophages. In Alcohol and the Cell, Rubin, E., Ed., Ann. NY Acad. Sci. 492: 324-326, 1987

  • Rubin, E., Ed. ALCOHOL AND THE CELL. Annals of the New York Academy of Sciences. 492, 1987

  • Taraschi TF, Ellingson JS, Wu A, Zimmerman R, Rubin E. Phosphatidylinositol from ethanol-fed rats confers membrane tolerance to ethanol. Proceedings of the National Academy of Sciences (USA). 83(24): 9398-402, Dec 1986

  • Ponnappa BC, Hoek JB, Sarchet K, Rubin E. Dietary carbohydrate level determines the effect of long-term ethanol ingestion on rat pancreatic amylase content. Journal of Laboratory and Clinical Medicine. 107(6): 556-62, Jun 1986

  • Taraschi TF, Ellingson JS, Wu A, Zimmerman R, Rubin E. Membrane tolerance to ethanol is rapidly lost after withdrawal: a model for studies of membrane adaptation. Proceedings of the National Academy of Sciences (USA). 83(11): 3669-73, Jun 1986

  • Ishii Y, Lehrer SS, Ohnishi ST, Rubin E. Effect of ethanol on tropomyosin in solution and in reconstituted thin filaments. Archives of Biochemistry and Biophysics. 246(2): 765-71, May 1986

  • Taraschi TF, Thayer WS, Ellingson JS, Rubin E. Effects of ethanol on the structure and function of rat liver mitochondrial and microsomal membranes. Annals of the New York Academy of Sciences. 488: 127-39, 1986

  • Rubin, E. Editorial: A new format for manuscripts. Laboratory Investigation. 55: 599, 1986

  • Taraschi TF, Wu A, Rubin E. Phospholipid spin probes measure the effects of ethanol on the molecular order of liver microsomes. Biochemistry. 24(25): 7096-101, Dec 1985

  • Rottenberg H, Robertson DE, Rubin E. The effect of temperature and chronic ethanol feeding on the proton electrochemical potential and phosphate potential in rat liver mitochondria. Biochimica Et Biophysica Acta. 809(1): 1-10, Aug 1985

  • Taraschi TF, Rubin E. Effects of ethanol on the chemical and structural properties of biologic membranes. Laboratory Investigation. 52(2): 120-31, Feb 1985

  • Ishii Y, Ohnishi ST, Rubin E. Action of ADP and ethanol on muscle proteins in vitro. Biochemical Pharmacology. 34(2): 203-10, Jan 1985

  • Taraschi, T.F. and Rubin, E. Ethanol and biological membranes: Experimental studies and theoretical considerations. In: Alcohol Related Diseases in Gastroenterology. Seitz, H. K. and Kommerell, B., Eds., Berlin, Heidelberg, Springer-Verlag. 213-231, 1985

  • Ohnishi ST, Flick JL, Rubin E. Ethanol increases calcium permeability of heavy sarcoplasmic reticulum of skeletal muscle. Archives of Biochemistry and Biophysics. 233(2): 588-94, Sep 1984

  • Dorio RJ, Hoek JB, Rubin E. Ethanol treatment selectively decreases neutral amino acid transport in cultured hepatocytes. Journal of Biological Chemistry. 259(18): 11430-5, Sep 1984

  • Kelly-Murphy S, Waring AJ, Rottenberg H, Rubin E. Effects of chronic ethanol consumption on the partition of lipophilic compounds into erythrocyte membranes. Laboratory Investigation. 50(2): 174-83, Feb 1984

  • Rottenberg H, Waring A, Rubin E. Alcohol-induced tolerance in mitochondrial membranes.[letter]. Science. 223(4632): 193-4, Jan 1984

  • Rubin, E. Command performance. JAMA. 13: 1689, 1984

  • Rubin, E. and Damjanov. I., Eds. ADVANCES IN THE BIOLOGY OF DISEASE, Williams & Wilkins, Baltimore, Md. , 1984

  • Berman WJ, Gil J, Jennett RB, Tuma D, Sorrell MF, Rubin E. Ethanol, hepatocellular organelles, and microtubules. A morphometric study in vivo and in vitro. Laboratory Investigation. 48(6): 760-7, Jun 1983

  • Thayer WS, Rubin E. Antimycin inhibition as a probe of mitochondrial function in isolated rat hepatocytes. Effects of chronic ethanol consumption. Biochimica Et Biophysica Acta. 721(4): 328-35, Dec 1982

  • Ponnappa BC, Waring AJ, Hoek JB, Rottenberg H, Rubin E. Chronic ethanol ingestion increases calcium uptake and resistance to molecular disordering by ethanol in liver microsomes. Journal of Biological Chemistry. 257(17): 10141-6, Sep 1982

  • Waring AJ, Rottenberg H, Ohnishi T, Rubin E. The effect of chronic ethanol consumption on temperature-dependent physical properties of liver mitochondrial membranes. Archives of Biochemistry and Biophysics. 216(1): 51-61, Jun 1982

  • Rubin E. Alcohol and the heart: theoretical considerations. Federation Proceedings. 41(8): 2460-4, Jun 1982

  • Rubin E, Rottenberg H. Ethanol-induced injury and adaptation in biological membranes. Federation Proceedings. 41(8): 2465-71, Jun 1982

  • Rottenberg, H., Waring, A.J. and Rubin, E. The molecular basis of alcohol tolerance and drug cross-tolerance in chronic alcoholism. Biophysical Journal. 37: 14-16, 1982

  • Rubin, J.I. and Rubin, E. Myocardial toxicity of alcohols, aldehydes and glycols, including alcoholic cardiomyopathy. In: Cardiovascular Toxicology, Van Stee, E. W., Ed., Raven Press. 353-363, 1982

  • Skarinsky, E. and Rubin, E. The biology of viral hepatitis. In: Current Topics in Inflammation and Infection. Internat. Academy of Pathology Monograph #23. Baltimore, Waverly Press. 156-187, 1982

  • Rottenberg H, Waring A, Rubin E. Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs. Science. 213(4507): 583-5, Jul 1981

  • Thayer WS, Rubin E. Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption. Journal of Biological Chemistry. 256(12): 6090-7, Jun 1981

  • Waring AJ, Rottenberg H, Ohnishi T, Rubin E. Membranes and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol. Proceedings of the National Academy of Sciences (USA). 78(4): 2582-6, Apr 1981

  • Schanne FA, Zucker AH, Farber JL, Rubin E. Alcohol-dependent liver cell necrosis in vitro: a new model. Science. 212(4492): 338-40, Apr 1981

  • Giknis, M.L.A., Damjanov, I. and Rubin, E. Ethanol narcophylaxis: Prolongation of ethanol-induced sleeping time by preconditioning. Res. Commun. Sub.Abuse. 2: 85-92, 1981

  • Rubin, E. Alcohol: Tonic or toxic?. Cardiovascular Reviews and Reports. 2: 23-29, 1981

  • Rubin, E. (Book Review). Liver biopsy interpretation, P. J. Scheuer, 3rd Ed., Bailliere Tindall, London, 1980. Human Pathology. 12: 296, 1981

  • Rubin, E. Viral hepatitis: A symposium. Human Pathology. 12: 1060-1122, 1981

  • Rosa J, Rubin E. Effects of ethanol on amino acid uptake by rat liver cells. Laboratory Investigation. 43(4): 366-72, Oct 1980

  • Rubin E. Iatrogenic hepatic injury. Human Pathology. 11(4): 312-31, Jul 1980

  • Thayer WS, Ohnishi T, Rubin E. Characterization of iron-sulfur clusters in rat liver submitochondrial particles by electron paramagnetic resonance spectroscopy. Alterations produced by chronic ethanol consumption. Biochimica Et Biophysica Acta. 591(1): 22-36, Jun 1980

  • Rottenberg H, Robertson DE, Rubin E. The effect of ethanol on the temperature dependence of respiration and ATPase activities of rat liver mitochondria. Laboratory Investigation. 42(3): 318-26, Mar 1980

  • Rottenberg H, Robertson DE, Rubin E. The temperature dependence of respiration and ATPase in rat liver mitochondria is altered by ethanol. Advances in Experimental Medicine and Biology. 132: 345-53, 1980

  • Thayer WS, Rubin E. Effects of chronic ethanol consumption on the respiratory chain of rat liver submitochondrial particles. Advances in Experimental Medicine and Biology. 132: 385-92, 1980

  • Giknis, M.L.A., Damjanov, I. and Rubin, E. The differential transplacental effects of ethanol in four mouse strains. Neurobehavioral Toxicology. 2: 235-237, 1980

  • Rubin, E. Cardiovascular effects of alcohol. Proceedings of Fifth Biennial Symposium on Alcoholism, Cardiff, Wales. Pharmacology, Biochemistry and Behavior. 13: 37-41, 1980

  • Rubin E. Acute and chronic viral hepatitis. Federation Proceedings. 38(13): 2665-73, Dec 1979

  • Burke JP, Rubin E. The effects of ethanol and acetaldehyde on the products of protein synthesis by liver mitochondria. Laboratory Investigation. 41(5): 393-400, Nov 1979

  • Thayer WS, Rubin E. Effects of chronic ethanol intoxication on oxidative phosphorylation in rat liver submitochondrial particles. Journal of Biological Chemistry. 254(16): 7717-23, Aug 1979

  • Sun AS, Alvarez LJ, Reinach PS, Rubin E. 5'-Nucleotidase levels in normal and virus-transformed cells: implications for cellular aging in vitro. Laboratory Investigation. 41(1): 1-4, Jul 1979

  • Rubin E. Alcoholic myopathy in heart and skeletal muscle. New England Journal of Medicine. 301(1): 28-33, Jul 1979

  • Cederbaum AI, Dicker E, Rubin E, Cohen G. Effect of thiourea on microsomal oxidation of alcohols and associated microsomal functions. Biochemistry. 18(7): 1187-91, Apr 1979

  • Rubin, E. Metabolic and pathologic changes in muscle during acute and chronic administration of ethanol. In: Biochemistry and Pharmacology of Ethanol, Majchrowicz, E. and Noble, E. P., Eds., New York, Plenum Press. I: 623-639, 1979

  • Rubin, E. Effects of alcohol and acetaldehyde in vitro and in vivo, on subcellular constituents of the heart. Workshop on Cardiomyopathies, Jennings, R. B. and Morgan, H. E., Chairman, NIH Publication #79-1608. 6, 1979

  • Cederbaum AI, Dicker E, Lieber CS, Rubin E. Ethanol oxidation by isolated hepatocytes from ethanol-treated and control rats. Biochemical Pharmacology. 27(1): 7-15, Jan 1978

  • Cederbaum AI, Dicker E, Rubin E. Transfer and reoxidation of reducing equivalents as the rate-limiting steps in the oxidation of ethanol by liver cells isolated from fed and fasted rats. Archives of Biochemistry and Biophysics. 183(2): 638-46, Oct 1977

  • Cederbaum AI, Dicker E, Rubin E, Cohen G. The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes. Biochemical and Biophysical Research Communications. 78(4): 1254-62, Oct 1977

  • Retig JN, Kirchberger MA, Rubin E, Katz AM. Effects of ethanol on calcium transport by microsomes phosphorylated by cyclic AMP-dependent protein kinase. Biochemical Pharmacology. 26(5): 393-6, Mar 1977

  • Cederbaum AI, Rubin E. The oxidation of acetaldehyde by isolated mitochondria from various organs of the rat and hepatocellular carcinoma. Archives of Biochemistry and Biophysics. 179(1): 46-66, Feb 1977

  • Cederbaum AI, Dicker E, Lieber CS, Rubin E. Factors contributing to the adaptive increase in ethanol metabolism due to chronic consumption of ethanol. Alcoholism, Clinical and Experimental Research. 1(1): 27-31, Jan 1977

  • Cederbaum, A.I. and Rubin, E. Sensitivity to acetaldehyde of pyruvate oxidation by mitochondria from liver, kidney, brain and muscle. Biochemical Pharmacology. 26: 1349-1353, 1977

  • Geller, S.A. and Rubin, E. The effects of alcohol on striated and smooth muscle. In: Metabolic Aspects of Alcoholism, Lieber, C. S., Ed., Baltimore, University Park Press. 187-213, 1977

  • Rubin, E. and Cederbaum, A.I. Organelle pathology of alcohol-induced hepatic injury. In: Alcohol and the Liver. Fischer, M. M. and Rankin, J. G., Eds., New York, Plenum Press. 167-196, 1977

  • Puskin S, Rubin E. Effects of ADP, ethanol and acetaldehyde on the relaxing complex of human muscle and its adsorption by polystyrene particles. Archives of Biochemistry and Biophysics. 177(2): 574-84, Dec 1976

  • Cederbaum AI, Rubin E. Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury. Biochemical Pharmacology. 25(19): 2179-85, Oct 1976

  • Gordon GG, Altman K, Southren AL, Rubin E, Lieber CS. Effect of alcohol (ethanol) administration on sex-hormone metabolism in normal men. New England Journal of Medicine. 295(15): 793-7, Oct 1976

  • Cederbaum AI, Becker FF, Rubin E. Ethanol metabolism by a transplantable hepatocellular carcinoma. Role of microsomes and mitochondria. Journal of Biological Chemistry. 251(17): 5366-74, Sep 1976

  • Cederbaum AI, Rubin E. Fatty acid oxidation, substrate shuttles, and activity of the citric acid cycle in hepatocellular carcinomas of varying differentiation. Cancer Research. 36(9 pt.1): 2980-7, Sep 1976

  • Cederbaum AI, Rubin E. Kinetic properties of alcohol dehydrogenase in hepatocellular carcinoma and normal tissues of rat. Cancer Research. 36(7 PT 1): 2274-7, Jul 1976

  • Cederbaum AI, Madhavan TV, Rubin E. Effect of chronic clofibrate administration on mitochondrial fatty acid oxidation. Biochemical Pharmacology. 25(11): 1285-92, Jun 1976

  • Rubin E, Katz AM, Lieber CS, Stein EP, Puszkin S. Muscle damage produced by chronic alcohol consumption. American Journal of Pathology. 83(3): 499-515, Jun 1976

  • Cederbaum AI, Rubin E. Protective effect of cysteine on the inhibition of mitochondrial functions by acetaldehyde. Biochemical Pharmacology. 25(8): 963-73, Apr 1976

  • Rubin E, Lieber CS, Altman K, Gordon GG, Southren AL. Prolonged ethanol consumption increases testosterone metabolism in the liver. Science. 191(4227): 563-4, Feb 1976

  • Rubin, E. and Cederbaum, A.I. Molecular localization of mitochondrial injury produced by chronic ethanol consumption and acetaldehyde. 2nd International Gstaad Symposium. The Liver. Quantitative Aspects of Structure and Function. Preisig, R., Bircher, J. and Paumgartner, G., Eds. 192-204, 1976

  • Cederbaum, A.I., Lieber, C.S. and Rubin, E. The effects of chronic ethanol consumption and acetaldehyde on hepatic mitochondria. In: Diseases of the Liver and Biliary Tract, 5th Quadr. Meeting International Association of the Study of the Liver, Acapulco, Leevy, C. M., Ed., Basel, S. Karger. 85-91, 1976

  • Lieber, C.S., Rubin, E., DeCarli, L.M. and Feinman, L. Respective roles of ethanol and protein deficiency in the pathogenesis of alcoholic hepatitis and cirrhosis. In: Diseases of the Liver and Biliary Tract. 5th Quadr. Meeting International Association of the Study of the Liver, Acapulco, Leevy, C. M., Ed., Basel, S. Karger. 92-98, 1976

  • Rubin, E. Primary hepatocellular carcinoma - a resume. In: Liver Cell Cancer. Cameron, H. M., Linsell, D. A. and Warwick, G. P., Eds., Elsevier Scientific Publ. Co. 279-286, 1976

  • Rubin, E. and Cederbaum, A.I. Organelle pathology of alcoholic liver disease. In: Alcohol and the Liver. Israel, Y. and Khanna, J. M., Eds., New York City, Plenum Press. 167-193, 1976

  • Lieber, C.S., Feinman, L. and Rubin, E. Alcohol and the liver. In: Gastroenterology, Vol. III, Bockus, H. L., Ed., Philadelphia, W. B. Saunders Co. 342-365, 1976

  • Gang, H., Rubin, E. and Kamath, S.A. Hepatic plasma membrane enzymes in acute alcoholism. Proc. IVth Internat.Congress on Liver Diseases. Basel, Switzerland. , 1976

  • Cederbaum AI, Pietrusko R, Hempel J, Becker FF, Rubin E. Characterization of a nonhepatic alcohol dehydrogenase from rat hepatocellular carcinoma and stomach. Archives of Biochemistry and Biophysics. 171(1): 348-60, Nov 1975

  • Cederbaum AI, Rubin E. Molecular injury to mitochondria produced by ethanol and acetaldehyde. Federation Proceedings. 34(11): 2045-51, Oct 1975

  • Cederbaum AI, Lieber CS, Beattie DS, Rubin E. Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria. Journal of Biological Chemistry. 250(13): 5122-9, Jul 1975

  • Cederbaum AI, Lieber CS, Rubin E. Effect of acetaldehyde on fatty acid oxidation and ketogenesis by hepatic mitochondria. Archives of Biochemistry and Biophysics. 169(1): 29-41, Jul 1975

  • Puszkin S, Rubin E. Adenosine diphosphate effect on contractility of human muscle actomyosin: inhibition by ethanol and acetaldehyde. Science. 188(4195): 1319-20, Jun 1975

  • Rubin E, Lieber CS. Relation of alcoholic liver injury to cirrhosis. Clinics in Gastroenterology. 4(2): 247-72, May 1975

  • Cederbaum AI, Rubin E. Differential effects of acetate on palmitate and octanoate oxidation: segregation of acetyl CoA pools. Archives of Biochemistry and Biophysics. 166(2): 618-28, Feb 1975

  • Lieber CS, DeCarli L, Rubin E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proceedings of the National Academy of Sciences (USA). 72(2): 437-41, Feb 1975

  • Williams JW, Tada M, Katz AM, Rubin E. Effect of ethanol and acetaldehyde on the (Na K )-activated adenosine triphosphatase activity of cardiac plasma membranes. Biochemical Pharmacology. 24(1): 27-32, Jan 1975

  • Kamath SA, Rubin E. The use of cation-bound microsomes for studies of protein synthesis. Laboratory Investigation. 32(1): 10-6, Jan 1975

  • Rubin E. Symposium on pathology of the gastrointestinal tract--Part I. Introduction. Human Pathology. 6(1): 5-6, Jan 1975

  • Rubin E. Editorial: The specialist and the subspecialist: pathologist vs. clinician. Human Pathology. 6(1): 127-8, Jan 1975

  • Rubin, E. and Cederbaum, A.I. Effects of ethanol and acetaldehyde on hepatic mitochondria. In: Alcoholic Liver Pathology. Khanna, J. M., Israel, Y. and Kalant, H., Eds., Addiction Research Foundation, Toronto, Canada. 305-329, 1975

  • Rubin, E., Editor. Symposium on pathology of the gastrointestinal tract. Part II. Human Pathology. 6: 157-250, 1975

  • Cederbaum AI, Lieber CS, Rubin E. Effects of chronic ethanol treatment of mitochondrial functions damage to coupling site I. Archives of Biochemistry and Biophysics. 165(2): 560-9, Dec 1974

  • Swartz MH, Repke DI, Katz AM, Rubin E. Effects of ethanol on calcium binding and calcium uptake by cardiac microsomes. Biochemical Pharmacology. 23(17): 2369-76, Sep 1974

  • Cederbaum AI, Rubin E. Effects of clofibrate on mitochondrial function. Biochemical Pharmacology. 23(14): 1985-96, Jul 1974

  • Kamath SA, Rubin E. A short procedure to measure phospholipid exchange in mitochondria and microsomes. Analytical Biochemistry. 59(1): 172-7, May 1974

  • Kamath SA, Rubin E. Effects of carbon tetrachloride and phenobarbital on plasma membranes. Enzymes and phospholipid transfer. Laboratory Investigation. 30(4): 494-9, Apr 1974

  • Kamath SA, Rubin E. Alterations in the rate of phospholipid exchange between cell membranes. Laboratory Investigation. 30(4): 500-4, Apr 1974

  • Rubin E, Lieber CS. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. New England Journal of Medicine. 290(3): 128-35, Jan 1974

  • Cederbaum AI, Rubin E. Effects of pyrazole, 4-bromopyrazole and 4-methylpyrazole on mitochrondrial function. Biochemical Pharmacology. 23(2): 203-13, Jan 1974

  • Rubin, E. and Cederbaum, A.I. Effect of chronic ethanol consumption and acetaldehyde on mitochondrial functions and the transfer of reducing equivalents. In: Alcohol and Aldehyde Metabolizing Systems, Thurman, R. G., Yonetani, T., Williamson, J. R. and Chance, B. Eds., New York, Academic Press. 435-455, 1974

  • Rubin, E. and Lieber, C.S. The effects of alcohol on the human liver. In: The Liver and its Diseases. Schaffner, F., Sherlock, S. and Leevy, C., Eds., New York, International Medical Book Corp. 236-244, 1974

  • Rubin, E. Morphologic studies of alcoholic liver injury. In: Alcohol and Abnormal Protein Biosynthesis. Rothschild, M. A., Oratz, M. and Schreiber, S. S., Eds., Pergamon Press. 295-319, 1974

  • Rubin, E. Alcohol and the liver. IV. Congreso de la Sociedad Latinoamericana de Hepatologia. In: Hepatologia. Beker, S. G. and Grases, P. J., Eds. 134-136, 1974

  • Cederbaum AI, Lieber CS, Rubin E. Effect of acetaldehyde on activity of shuttles for the transport of reducing equivalents into the mitochondria. Febs Letters. 37(1): 89-92, Nov 1973

  • Rubin E, Lieber CS. Experimental alcoholic hepatitis: a new primate model. Science. 1
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