University Home | Hospital | Pulse Employment | Contact Us | Search | News 
Thomas Jefferson University Search Jefferson
Jefferson Medical College Jefferson College of Graduate Studies Jefferson College of Health Professions
Menu

Thomas Jefferson University - John L. Farber, M.D.
John L. Farber, M.D.

Pathology, Anatomy and Cell Biology
Thomas Jefferson University
Jefferson Medical College
Department of Pathology
Anatomy & Cell Biology
Professor Appointed: 1986

Thomas Jefferson University
Jefferson Medical College
Pharmacology
Professor

Mailing Address
1020 Locust Street
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (215) 503-5066
Fax: (215) 923-2218
John.Farber@jefferson.edu
Qualifications
B.A., Reed College, 1962

San Francisco, University of California, M.D.,

Board certification, American Board of Pathology, Diplomate, Anatomic Pathology

Medical licensure, Commonwealth of Pennsylvania, 1970

Other Expertise

EXTRACURRICULAR ACTIVITIES (1997-present)
Board of Scientific Counselors, National Institute of Environmental Health Sciences, 1997-Present

EDITORIAL BOARDS (1997-present):
Experimental and Molecular Pathology 1983-Present
Cell Biology and Toxicology 1985-present
Toxicologic Pathology 1988-1997
Chemico-Biological Interactions 1990-1998
Cell Death and Differentiation 1994-Present
Toxicology In Vitro 1992-Present
International Hepatology Communications 1992-Present
Modern Pathology 1995-Present
Human Pathology 1998-Present
Keywords
Apoptosis; Cell Death; Cellular Pathology; Diabetes; Digestive Diseases And Disorders; Digestive System; Kidney (Renal) Functions; Kidney Disease; Mitochondria; Necrosis; Urology
Publications
  • Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima YA, Farber JL, Tanaka M. A possible role for centrosome overduplication in radiation-induced cell death. Oncogene. 19(46): 5281-90, 2000

  • Fong LY, Nguyen VT, Farber JL, Huebner K, Magee PN. Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. Cancer Research. 60(16): 4589-95, Aug 2000

  • Tafani M, Schneider TG, Pastorino JG, Farber JL. Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. American Journal of Pathology. 156(6): 2111-21, Jun 2000

  • Rubin, E., and Farber, J.L. (eds). Essential Pathology, 3rd Ed. Lippincott Williams & Wilkins, Philadelphia, PA. , 2000

  • Pastorino JG, Tafani M, Rothman RJ, Marcineviciute A, Hoek JB, Farber JL. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. Journal of Biological Chemistry. 274(44): 31734-9, Oct 1999

  • Pastorino JG, Tafani M, Farber JL. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. Journal of Biological Chemistry. 274(27): 19411-6, Jul 1999

  • Glascott PA Jr, Farber JL. Assessment of physiological interaction between vitamin E and vitamin C. Methods in Enzymology. 300: 78-88, 1999

  • Rubin E, Farber, JL (eds). Pathology, 3rd Ed. Lippincott-Raven, Philadelphia, PA. , 1999

  • Fong LY, Farber JL, Magee PN. Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats. Carcinogenesis. 19(9): 1591-6, Sep 1998

  • Albertine KH, Steiner RM, Radack DM, Golding DM, Peterson D, Cohn HE, Farber JL. Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma. Chest. 113(4): 997-1006, Apr 1998

  • Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. Journal of Biological Chemistry. 273(13): 7770-5, Mar 1998

  • Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, Akaike T, Maeda H, Koprowski H. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proceedings of the National Academy of Sciences (USA). 94(6): 2528-33, 1997

  • Simbula G, Glascott PA Jr, Akita S, Hoek JB, Farber JL. Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition. American Journal of Physiology. 273(2 Pt 1): C479-88, Aug 1997

  • Spitsin SV, Farber JL, Bertovich M, Moehren G, Koprowski H, Michaels FH. Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-kappa B. Molecular Medicine. 3(5): 315-26, May 1997

  • Sanchez-Gongora E, Pastorino JG, Alvarez L, Pajares MA, Garcia C, Vina JR, Mato JM, Farber JL. Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA. Biochemical Journal. 319 ( Pt 3): 767-73, Nov 1996

  • Pastorino JG, Simbula G, Yamamoto K, Glascott PA Jr, Rothman RJ, Farber JL. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. Journal of Biological Chemistry. 271(47): 29792-8, Nov 1996

  • Glascott PA Jr, Gilfor E, Serroni A, Farber JL. Independent antioxidant action of vitamins E and C in cultured rat hepatocytes intoxicated with allyl alcohol. Biochemical Pharmacology. 52(8): 1245-52, Oct 1996

  • Glascott PA Jr, Tsyganskaya M, Gilfor E, Zern MA, Farber JL. The antioxidant function of the physiological content of vitamin C. Molecular Pharmacology. 50(4): 994-9, Oct 1996

  • Fong LY, Li JX, Farber JL, Magee PN. Cell proliferation and esophageal carcinogenesis in the zinc-deficient rat. Carcinogenesis. 17(9): 1841-8, Sep 1996

  • Snyder JW, Serroni A, Savory J, Farber JL. The absence of extracellular calcium potentiates the killing of cultured hepatocytes by aluminum maltolate. Archives of Biochemistry and Biophysics. 316(1): 434-42, Jan 1995

  • Hoek JB, Farber JL, Thomas AP, Wang X. Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition. Biochimica et Biophysica Acta. 1271(1): 93-102, 24 1995

  • Glascott PA Jr, Gilfor E, Farber JL. Relationship of the metabolism of vitamins C and E in cultured hepatocytes treated with tert-butyl hydroperoxide. Molecular Pharmacology. 48(1): 80-8, 1995

  • Mizumoto K, Farber JL. Growth inhibition and cell killing by N-methyl-N-nitrosourea: metabolic alterations that accompany poly\(ADP-ribosyl\)ation. Archives of Biochemistry and Biophysics. 319(2): 512-8, 1995

  • Pastorino JG, Wilhelm TJ, Glascott PA Jr, Kocsis JJ, Farber JL. Dexamethasone induces resistance to the lethal consequences of electron transport inhibition in cultured hepatocytes. Archives of Biochemistry and Biophysics. 318(1): 175-81, 1995

  • Pastorino JG, Snyder JW, Hoek JB, Farber JL. Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition. American Journal of Physiology. 268(3 Pt 1): C676-85, 1995

  • Rubin E, Farber, JL (eds). Essential Pathology, 2nd Ed. J.B. Lippincott Co., Philadelphia, PA. , 1995

  • Farber JL. Mechanisms of cell injury. In: Pathology of Human Environmental and Occupational Disease, Craighead, J.E., ed., Mosby-Year Book, Philadelphia, Pa. , 1995

  • Farber JL. Mechanisms of cell injury by activated oxygen species. Environmental Health Perspectives. 102 Suppl 10: 17-24, Dec 1994

  • Pastorino JG, Simbula G, Gilfor E, Hoek JB, Farber JL. Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. Journal of Biological Chemistry. 269(49): 31041-6, Dec 1994

  • Mizumoto K, Rothman RJ, Farber JL. Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide. Molecular Pharmacology. 46(5): 890-5, Nov 1994

  • Russo MA, Morgante E, Mariani MF, Yeh HI, Farber JL, van Rossum GD. Effects of ouabain and chloride-free medium on isoosmotic volume control and ultrastructure of hepatocytes in primary culture. European Journal of Cell Biology. 64(2): 229-42, Aug 1994

  • Rubin E, Farber, JL (eds). Pathology. 2nd Ed., J.B. Lippincott Co., Philadelpha, PA. , 1994

  • Mizumoto K, Glascott PA Jr, Farber JL. Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate. Biochemical Pharmacology. 46(10): 1811-8, Nov 1993

  • Tsukidate K, Yamamoto K, Snyder JW, Farber JL. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. American Journal of Pathology. 143(3): 918-25, Sep 1993

  • Snyder JW, Alexander GM, Ferraro TN, Grothusen JR, Farber JL. N-methyl-4-phenylpyridinium (MPP ) potentiates the killing of cultured hepatocytes by catecholamines. Chemico-biological Interactions. 88(2-3): 209-23, Sep 1993

  • Yamamoto K, Tsukidate K, Farber JL. Differing effects of the inhibition of poly(ADP-ribose) polymerase on the course of oxidative cell injury in hepatocytes and fibroblasts. Biochemical Pharmacology. 46(3): 483-91, Aug 1993

  • Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. Journal of Biological Chemistry. 268(19): 13791-8, Jul 1993

  • Snyder JW, Pastorino JG, Thomas AP, Hoek JB, Farber JL. ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide. American Journal of Physiology. 264(3 Pt 1): C709-14, Mar 1993

  • Rothman RJ, Serroni A, Farber JL. Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Molecular Pharmacology. 42(4): 703-10, Oct 1992

  • Sakaida I, Thomas AP, Farber JL. Phospholipid metabolism and intracellular Ca2 homeostasis in cultured rat hepatocytes intoxicated with cyanide. American Journal of Physiology. 263(3 Pt 1): C684-90, Sep 1992

  • Snyder JW, Pastorino JG, Attie AM, Farber JL. Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium. Biochemical Pharmacology. 44(4): 833-5, Aug 1992

  • Glascott PA Jr, Gilfor E, Farber JL. Effects of vitamin E on the killing of cultured hepatocytes by tert-butyl hydroperoxide. Molecular Pharmacology. 41(6): 1155-62, Jun 1992

  • Yamamoto K, Farber JL. Metabolism of pyridine nucleotides in cultured rat hepatocytes intoxicated with tert-butyl hydroperoxide. Biochemical Pharmacology. 43(5): 1119-26, Mar 1992

  • Farber JL. The biochemistry of cell death. J. Toxicol. Pathol. 5: 1-9, 1992

  • Harman AW, Kyle ME, Serroni A, Farber JL. The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen. Biochemical Pharmacology. 41(8): 1111-7, Apr 1991

  • Sakaida I, Thomas AP, Farber JL. Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. Journal of Biological Chemistry. 266(2): 717-22, Jan 1991

  • Kyle ME, Farber JL. Biochemical mechanisms of toxic cell injury. In Handbook of Toxicologic Pathology, Hachek-Hock, W. M. and Rousseaux, C.G., eds., Academic Press, Orlando, Fla. 71-80, 1991

  • Farber JL. The role of calcium in lethal cell injury. Chemical Research in Toxicology. 3(6): 503-8, 1990

  • Kehrer JP, Jones DP, Lemasters JJ, Farber JL, Jaeschke H. Mechanisms of hypoxic cell injury. Summary of the symposium presented at the 1990 annual meeting of the Society of Toxicology. Toxicology and Applied Pharmacology. 106(2): 165-78, Nov 1990

  • Kyle ME, Sakaida I, Serroni A, Farber JL. Metabolism of acetaminophen by cultured rat hepatocytes. Depletion of protein thiol groups without any loss of viability. Biochemical Pharmacology. 40(6): 1211-8, Sep 1990

  • Coleman JB, Casini AF, Serroni A, Farber JL. Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. Toxicology and Applied Pharmacology. 105(3): 393-402, Sep 1990

  • Nakae D, Yoshiji H, Amanuma T, Kinugasa T, Farber JL, Konishi Y. Endocytosis-independent uptake of liposome-encapsulated superoxide dismutase prevents the killing of cultured hepatocytes by tert-butyl hydroperoxide. Archives of Biochemistry and Biophysics. 279(2): 315-9, Jun 1990

  • Farber JL, Kyle ME, Coleman JB. Mechanisms of cell injury by activated oxygen species. Laboratory Investigation. 62(6): 670-9, Jun 1990

  • Nakae D, Yamamoto K, Yoshiji H, Kinugasa T, Maruyama H, Farber JL, Konishi Y. Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen. American Journal of Pathology. 136(4): 787-95, Apr 1990

  • Sakaida I, Kyle ME, Farber JL. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Molecular Pharmacology. 37(3): 435-42, Mar 1990

  • Farber JL. The role of calcium ions in toxic cell injury. Environmental Health Perspectives. 84: 107-11, Mar 1990

  • Rubin E,Farber JL. Environmental diseases of the digestive system. Medical Clinics of North America. 74(2): 413-24, Mar 1990

  • Rubin E, Farber, JL (eds). Essential Pathology. J.B. Lippincott Co., Philadelphia, PA. , 1990

  • Kyle ME, Nakae D, Sakaida S, Serroni A, Farber JL. Protein thiol depletion and the killing of cultured hepatocytes by hydrogen peroxide. Biochemical Pharmacology. 38(21): 3797-805, Nov 1989

  • Farber JL, Holowecky OO, Serroni A, van Rossum GD. Effects of ouabain on potassium transport and cell volume regulation in rat and rabbit liver. Journal of Physiology. 417: 389-402, Oct 1989

  • Masaki N, Sakaida I, Farber JL. Protease inhibitors do not prevent the killing of cultured hepatocytes by cystamine. Biochemical and Biophysical Research Communications. 163(1): 412-7, Aug 1989

  • Coleman JB, Gilfor D, Farber JL. Dissociation of the accumulation of single-strand breaks in DNA from the killing of cultured hepatocytes by an oxidative stress. Molecular Pharmacology. 36(1): 193-200, Jul 1989

  • Masaki N, Thomas AP, Hoek JB, Farber JL. Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization. Archives of Biochemistry and Biophysics. 272(1): 152-61, Jul 1989

  • Masaki N, Kyle ME, Serroni A, Farber JL. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Archives of Biochemistry and Biophysics. 270(2): 672-80, May 1989

  • Masaki N, Kyle ME, Farber JL. tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Archives of Biochemistry and Biophysics. 269(2): 390-9, Mar 1989

  • Kyle ME, Serroni A, Farber JL. The inhibition of lipid peroxidation by disulfiram prevents the killing of cultured hepatocytes by allyl alcohol, tert-butyl hydroperoxide, hydrogen peroxide and diethyl maleate. Chemico-biological Interactions. 72(3): 269-75, 1989

  • Nakae D, Oakes JW, Farber JL. Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea. Archives of Biochemistry and Biophysics. 267(2): 651-9, Dec 1988

  • Farber JL, Leonard TB, Kyle ME, Nakae D, Serroni A, Rogers SA. Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes. Archives of Biochemistry and Biophysics. 267(2): 640-50, Dec 1988

  • Kyle ME, Nakae D, Serroni A, Farber JL. 1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals. Molecular Pharmacology. 34(4): 584-9, Oct 1988

  • Miccadei S, Nakae D, Kyle ME, Gilfor D, Farber JL. Oxidative cell injury in the killing of cultured hepatocytes by allyl alcohol. Archives of Biochemistry and Biophysics. 265(2): 302-10, Sep 1988

  • Miccadei S, Kyle ME, Gilfor D, Farber JL. Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes. Archives of Biochemistry and Biophysics. 265(2): 311-20, Sep 1988

  • Kyle ME, Nakae D, Sakaida I, Miccadei S, Farber JL. Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide. Journal of Biological Chemistry. 263(8): 3784-9, Mar 1988

  • Rubin E, Farber, JL (eds). J.B. Lippincott Co., Philadelphia, PA. Pathology. , 1988

  • Farber JL. Calcium ions and ischemic liver cell injury. In Calcium-dependent Processes in the Liver, Heilmann, C., ed., MTP Press Limited, Lancaster, England. 213, 1988

  • Farber JL. Cultured hepatocytes in the study of the hepatotoxicity of acetaminophen. In Alternative Methods in Toxicology, Goldberg, A.M., ed., Mary Ann Leibert, Inc., New York. 6: 49-60, 1988

  • Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochemical and Biophysical Research Communications. 149(3): 889-96, Dec 1987

  • Gerson RJ, Serroni A, Gilfor D, Ellen JM, Farber JL. Killing of cultured hepatocytes by the mixed-function oxidation of ethoxycoumarin. Biochemical Pharmacology. 35(23): 4311-9, Dec 1986

  • Starke PE, Hoek JB, Farber JL. Calcium-dependent and calcium-independent mechanisms of irreversible cell injury in cultured hepatocytes. Journal of Biological Chemistry. 261(7): 3006-12, Mar 1986

  • Farber JL. Biochemical mechanisms of toxic cell injury. Klinische Wochenschrift. 64 Suppl 7: 142-3, 1986

  • Farber John L. The biochemical pathology of toxic cell death. In: The Pathologist and the Environment, Scarpelli, D., and Craighead, J., eds., Williams and Wilkins, Baltimore. 19-31, 1986

  • Farber JL. Xenobiotics, drug methabolism, and the liver. In The Liver (Farber, E. and Philips, J., eds.) Williams and Wilkins, Baltimore. 43-53, 1986

  • Starke PE, Gilbertson JD, Farber JL. Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxide. Biochemical and Biophysical Research Communications. 133(2): 371-9, Dec 1985

  • Kane AB, Petrovich DR, Stern RO, Farber JL. ATP depletion and loss of cell integrity in anoxic hepatocytes and silica-treated P388D1 macrophages. American Journal of Physiology. 249(3 Pt 1): C256-66, Sep 1985

  • Starke PE, Farber JL. Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction. Journal of Biological Chemistry. 260(18): 10099-104, Aug 1985

  • Finkelstein SD, Gilfor D, Farber JL. Alterations in the metabolism of lipids in ischemia of the liver and kidney. Journal of Lipid Research. 26(6): 726-34, Jun 1985

  • Okayasu T, Curtis MT, Farber JL. Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury. Archives of Biochemistry and Biophysics. 236(2): 638-45, Feb 1985

  • Gerson RJ, Casini A, Gilfor D, Serroni A, Farber JL. Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen. Biochemical and Biophysical Research Communications. 126(3): 1129-37, Feb 1985

  • Starke PE, Farber JL. Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes. Journal of Biological Chemistry. 260(1): 86-92, Jan 1985

  • Curtis MT, Gilfor D, Farber JL. Lipid peroxidation increases the molecular order of microsomal membranes. Archives of Biochemistry and Biophysics. 235(2): 644-9, Dec 1984

  • Okayasu T, Curtis MT, Farber JL. Cytochalasin delays but does not prevent cell death from anoxia. American Journal of Pathology. 117(2): 163-6, Nov 1984

  • Petrovich DR, Finkelstein S, Waring AJ, Farber JL. Liver ischemia increases the molecular order of microsomal membranes by increasing the cholesterol-to-phospholipid ratio. Journal of Biological Chemistry. 259(21): 13217-23, Nov 1984

  • Rubin R, Farber JL. Mechanisms of the killing of cultured hepatocytes by hydrogen peroxide. Archives of Biochemistry and Biophysics. 228(2): 450-9, Feb 1984

  • Farber JL. The role of calcium in liver cell death. In: Mechanisms of Hepatocyte Injury and Death, Keppler, D., ed., pp. , MTP Press Limited, Lancaster, England. 111-118, 1984

  • Farber JL, Gerson RJ. Mechanisms of irreversible cell injury with hepatoxic chemicals. Pharmacological Reviews. 36(2 Suppl): 71S-75S, 1984

  • Farber JL. Editorial: How do mineral dusts cause lung injury?. Laboratory Investigation. 49: 379, 1983

  • Russo MA, Kane AB, Farber JL. Ultrastruct pathology of phalloidin-intoxicated hepatocytes in the presence and absence of extracellular calcium. American Journal of Pathology. 109(2): 133-44, Nov 1982

  • Farber JL. Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Laboratory Investigation. 47(2): 114-23, Aug 1982

  • Casini A, Giorli M, Hyland RJ, Serroni A, Gilfor D, Farber JL. Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene. Journal of Biological Chemistry. 257(12): 6721-8, Jun 1982

  • Farber JL. The role of calcium in liver cell death. In: Progress in Liver Diseases Popper, H. and Chaffner, F., eds., Grune & Stratton, Inc. VII: 347, 1982

  • Casini AF, Farber JL. Dependence of the carbon-tetrachloride--induced death of cultured hepatocytes on the extracellular calcium concentration. American Journal of Pathology. 105(2): 138-48, Nov 1981

  • Farber JL, Young EE. Accelerated phospholipid degradation in anoxic rat hepatocytes. Archives of Biochemistry and Biophysics. 211(1): 312-20, Oct 1981

  • Farber JL. The role of calcium in cell death. Life Sciences. 29(13): 1289-95, Sep 1981

  • Mittnacht S Jr, Farber JL. Reversal of ischemic mitochondrial dysfunction. Journal of Biological Chemistry. 256(7): 3199-206, Apr 1981

  • Schanne FA, Zucker AH, Farber JL, Rubin E. Alcohol-dependent liver cell necrosis in vitro: a new model. Science. 212(4492): 338-40, Apr 1981

  • Farber JL, Chien KR, Mittnacht S Jr. Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. American Journal of Pathology. 102(2): 271-81, Feb 1981

  • Chien KR, Sherman SC, Mittnacht S Jr, Farber JL. Microsomal membrane structure and function subsequent to calcium activation of an endogenous phospholipase. Archives of Biochemistry and Biophysics. 205(2): 614-22, Dec 1980

  • Kane AB, Stanton RP, Raymond EG, Dobson ME, Knafelc ME, Farber JL. Dissociation of intracellular lysosomal rupture from the cell death caused by silica. Journal of Cell Biology. 87(3 Pt 1): 643-51, Dec 1980

  • Schanne FA, Pfau RG, Farber JL. Galactosamine-induced cell death in primary cultures of rat hepatocytes. American Journal of Pathology. 100(1): 25-38, Jul 1980

  • Kane AB, Young EE, Schanne FA, Farber JL. Calcium dependence of phalloidin-induced liver cell death. Proceedings of the National Academy of Sciences (USA). 77(2): 1177-80, Feb 1980

  • Farber JL. Molecular mechanisms of toxic cell death. In: The Scientific Basis of Toxiciy Assessment, Witschi, H.P., ed., North Holland, Amsterdam, The Netherlands. 201, 1980

  • Chien KR, Peau RG, Farber JL. Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction. American Journal of Pathology. 97(3): 505-29, Dec 1979

  • Schanne FA, Kane AB, Young EE, Farber JL. Calcium dependence of toxic cell death: a final common pathway. Science. 206(4419): 700-2, Nov 1979

  • Mittnacht S Jr, Sherman SC, Farber JL. Reversal of ischemic mitochondrial dysfunction. Journal of Biological Chemistry. 254(19): 9871-8, Oct 1979

  • Schneiderman S, Farber JL, Baserga R. A simple method for decreasing the toxicity of polyethylene glycol in mammalian cell hybridization. Somatic Cell Genetics. 5(2): 263-9, Mar 1979

  • Farber JL. Reaction of the liver to injury: Necrosis. In: Toxic Liver Injury, Farber, E., and Fisher, M., eds., Marcell Dekker, Inc. 215, 1979

  • Farber JL, Martin JT, Chien KR. Irreversible ischemic cell injury. Prevention by chlorpromazine of the aggregation of the intramembranous particles of rat liver plasma membranes. American Journal of Pathology. 92(3): 713-32, Sep 1978

  • Chien KR, Abrams J, Serroni A, Martin JT, Farber JL. Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. Journal of Biological Chemistry. 253(13): 4809-17, Jul 1978

  • Chien KR, Abrams J, Pfau RG, Farber JL. Prevention by chlorpromazine of ischemic liver cell death. American Journal of Pathology. 88(3): 539-57, Sep 1977

  • Chien KR, Farber JL. Microsomal membrane dysfunction in ischemic rat liver cells. Archives of Biochemistry and Biophysics. 180(1): 191-8, Apr 1977

  • Farber JL, El-Mofty SK, Schanne FA, Aleo JJ Jr, Serroni A. Intracellular calcium homeostasis in galactosamine-intoxicated rat liver cells. Active sequestration of calcium by microsomes and mitochondria. Archives of Biochemistry and Biophysics. 178(2): 617-24, Jan 1977

  • Herzog J, Farber JL. Inhibition of rat liver RNA polymerases by action of the methylating agents dimethylnitrosamine in vivo and methyl methanesulfonate in vitro. Cancer Research. 36(5): 1761-70, May 1976

  • Farber JL, El-Mofty SK. The biochemical pathology of liver cell necrosis. American Journal of Pathology. 81(1): 237-50, Oct 1975

  • Organtini JE, Joseph CR, Farber JL. Increases in the activity of the solubilized rat liver nuclear RNA polymerases following partial hepatectomy. Archives of Biochemistry and Biophysics. 170(2): 485-91, Oct 1975

  • Herzog J, Serroni A, Briesmeister BA, Farber JL. N-hydroxy-2-acetylaminofluorene inhibition of rat live RNA polymerases. Cancer Research. 35(8): 2138-44, Aug 1975

  • Herzog J, Farber JL. Fibrillar nucleolar remnants do not contain macromolecular precursors of ribosomal RNA. Demonstration by the effects of d-galactosamine. Experimental Cell Research. 93(2): 502-5, Jul 1975

  • El-Mofty SK, Scrutton MC, Serroni A, Nicolini C, Farber JL. Early, reversible plasma membrane injury in galactosamine-induced liver cell death. American Journal of Pathology. 79(3): 579-95, Jun 1975

  • Farber JL, Shinozuka H, Serroni A, Farmar R. Reversal of the ethionine-induced inhibition of rat liver ribonucleic acid polymerases in vivo by adenine. Laboratory Investigation. 31(5): 465-72, Nov 1974

  • Konishi Y, Shinozuka H, Farber JL. The inhibition of rat liver nuclear ribonucleic acid synthesis by galactosamine and its reversal by uridine. Laboratory Investigation. 30(6): 751-6, Jun 1974

  • Shinozuka H, Martin JT, Farber JL. The induction of fibrillar nucleoli in rat liver cells by D-galactosamine and their subsequent re-formation into normal nucleoli. Journal of Ultrastructure Research. 44(3): 279-92, Aug 1973

  • Farber JL, Gill G, Konishi Y. Prevention of galactosamine-induced liver cell necrosis by uridine. American Journal of Pathology. 72(1): 53-62, Jul 1973

  • Shinozuka H, Farber JL, Konishi Y, Anukarahanonta T. D-galactosamine and acute liver cell injury. Federation Proceedings. 32(4): 1516-26, Apr 1973

  • Farber JL, Farmar R. Differential effects of cycloheximide on protein and RNA synthesis as a function of dose. Biochemical and Biophysical Research Communications. 51(3): 626-30, Apr 1973

  • Farber JL, Rovera G, Baserga R. Effect of homologous RNA polymerase on the increase in chromatin template activity of stimulated fibroblasts. Biochemical and Biophysical Research Communications. 49(2): 558-62, Oct 1972

  • Stein G, Farber J. Role of nonhistone chromosomal proteins in the restriction of mitotic chromatin template activity. Proceedings of the National Academy of Sciences (USA). 69(10): 2918-21, Oct 1972

  • Wilson SH, Schrier BK, Farber JL, Thompson EJ, Rosenberg RN, Blume AJ, Nirenberg MW. Markers for gene expression in cultured cells from the nervous system. Journal of Biological Chemistry. 247(10): 3159-69, May 1972

  • Farber J, Stein G, Baserga R. The regulation of RNA synthesis during mitosis. Biochemical and Biophysical Research Communications. 47(4): 790-7, May 1972

  • Farber JL. Pathology of RNA. In: The Pathology of Transcription and Translation, E. Farber, ed., Marcel Dekker, Inc., New York. , 1972

  • Baserga R, Rovera G, Farber J. Control of cellular proliferation in human diploid fibroblasts. In Vitro. 7(2): 80-7, 1971

  • Rovera G, Farber J, Baserga R. Gene activation in WI-38 fibroblasts stimulated to proliferate: requirement for protein synthesis. Proceedings of the National Academy of Sciences (USA). 68(8): 1725-9, Aug 1971

  • Farber J, Baserga R, Gabbay EJ. The effect of a reporter molecule on chromatin template activity. Biochemical and Biophysical Research Communications. 43(3): 675-81, May 1971

  • Farber J, Rovera G, Baserga R. Template activity of chromatin during stimulation of cellular proliferation in human diploid fibroblasts. Biochemical Journal. 122(2): 189-95, Apr 1971

  • Blume A, Gilbert F, Wilson S, Farber J, Rosenberg R, Nirenberg M. Regulation of acetylcholinesterase in neuroblastoma cells. Proceedings of the National Academy of Sciences (USA). 67(2): 786-92, Oct 1970

Individual Expertise profile of John L. Farber, M.D., Copyright © John L. Farber, M.D..
Last Updated by Admin : Wednesday, November 30, 2005 4:24:58 PM



Maintained by George Purkins
Copyright © Thomas Jefferson University. All Rights Reserved.

 Printable Version

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement.
Thomas Jefferson University