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Thomas Jefferson University - Raphael Rubin, M.D.
Raphael Rubin, M.D.

Pathology, Anatomy and Cell Biology
1995,Professor,Thomas Jefferson University,Jefferson Medical College,Department of Pathology, Anatomy & Cell Biology,
Mailing Address
132 South 10th St. suite 285 main
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-5031
Fax: 215-923-1969
Raphael.Rubin@jefferson.edu
Qualifications
B.A., Boston University, 6-year Medical Program, 1979

M.D., Boston University School of Medicine, 1979

Board Certification, American Board of Pathology, Anatomic Pathology, 1983

New York, Pennsylvania, Medical Licensure,

Expertise and Research Interests
Surgical Pathology
Gastrointestinal/Liver pathology

Growth factor and tyrosine kinase signaling
Insulin-like growth factor receptor signaling
Effects of alcohol on cell signaling
Other Expertise
CLINICAL APPOINTMENTS 1995-present
Thomas Jefferson University Hospital
1995-present
- Director, Hepatic Pathology
1986-present
- Attending Pathologist, Dept. Surgical Pathology
- Director, Hepatic Pathology



EDITORIAL BOARDS
Reviewing editor: Alcoholism: Clinical and Experimental Research, 2000, Modern Pathology, 1990- present, Human Pathology, 1994-present
Keywords
Alcohol; Alcoholism; Alcoholism Prevention; Alcoholism Treatment; glia; glioma; ligand; stroke; ethanol; granule; phorbol; platelet; cell type; secretion; fibroblast; morphology; neutrophil; arachidonate; cytoskeleton; phospholipid; animal tissue; human subject; messenger rna; laboratory rat; chemoprevention; phospholipase a; phospholipase c; phospholipase d; phosphorylation; laboratory mouse; protein kinase c; radioimmunoassay; membrane activity; northern blotting; stimulant agonist; insulinlike factor; protein metabolism; electron microscopy; platelet activation; tissue cell culture; cell differentiation; phosphatidylinositol; platelet aggregation; fluorescent dye probe; programmed cell death; fetal alcohol syndrome; growth factor receptor; guanosine triphosphate; phospholipase inhibitor; alcoholism alcohol abuse; insulinlike growth factor; thin layer chromatography; biological signal transduction; guanine nucleotide binding protein; electron spin resonance spectroscopy
Publications
  • Since 1999

  • Combes, B., Markin, R.S., Wheeler, D.E. RUBIN, R, West, A.B., Mills, A.S., Eigenbrodt, E.H., Maddrey, W.C., Munoz, S.J., Garcia-Tsao, G., Bonner, G.F., Boyer, J.L., Luketic, V.A., Shiffman, M.L., Peters, M.G., White, H.M., Zetterman, R.K., and Carithers, R.L. Jr. (1999) The effect of ursodeoxycholic acid on the florid duct lesion of primary biliary cirrhosis. Hepatology, 30, 602-605

  • Hallak, H., Seiler, A., Green, J., Ross, B., and RUBIN, R. (2000) Association of Heterotrimeric Gi with the Insulin-Like Growth Factor-I Receptor; Release of Gbg subunits upon receptor activation. J. Biol. Chem. 275, 2255-2258

  • Seiler, A.E.M., Ross, B.,Green, J.S., and RUBIN, R. (2000) Differential effects of ethanol on insulin-like growth factor-I receptor signaling. Alcohol.: Clin. Exp. Res. 24, 140-148

  • Seiler, A.E.M. Ross, B. and RUBIN, R. (2000) Inhibition of insulin-like growth factor-I receptor and IRS-2 signaling by ethanol in SH-SY5Y neuroblastoma cells. J. Neurochem. 76: 573-581

  • Seiler, A.E.M., Henderson, A., and RUBIN, R. (2000) Ethanol inhibits insulin receptor tyrosine kinase. Alcohol.: Clin. Exp. Res. 24, 1869-1872

  • Radomski, J., RUBIN, R. et al. (2000) Results of liver transplantation for nodular regenerative hyperplasia. American Surgeon. 66: 1067-1070.

  • RUBIN, R., Seiler, A., and Rooney, T. (2000) Ethanol-induced inhibition of insulin-like growth factor I signaling. In: Ethanol and intracellular signaling. NIH Press

  • Hallak, H., Ramadan, B. and RUBIN, R. (2001) Hydrogen peroxide induces tyrosine phosphorylation of IRS-1: modulation by NMDA and calcineurin. J. Neurochem. 24: 1869-1872

  • Baig, N.A., Herrine, S., and RUBIN, R. (2001) Liver disease in type II diabetes mellitus. Clinics in Lab. Medicine 21: 193-207

  • Hallak, H. , Seiler, A. E.M. , Green, J.S., Henderson, A., Ross, B.N., and RUBIN, R. (2001) Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells. Alcohol: Clin. Exp. Res. 25:1059-1064

  • Nascimento, A.B., Mitchell, D.G., RUBIN, R, and Weaver, E. (2001) Diffuse desmoplastic breast carcinoma metastases to the liver simulating cirrhosis at MR imaging: report of two cases. Radiology. 221:117-21.

  • Nascimento, A.B. Mitchell, D.G. RUBIN, R. and Weaver, E. (2002) Sinusoidal spread of liver metastases from renal cell carcinoma: simulation of diffuse liver disease on MR imaging. Abdom Imaging. 27:196-8.

  • Israel, Y., Crews, F.T., Thurman, R.G., Tu, G.C., Garver, E., Ponnappa, B., RUBIN, R., Hoplight, B., Sethna, M., Hanes, R., Wilkie, M.B., and Wheeler, M.D. (2002) Gene and antisense delivery in alcoholism research. Alcohol. Clin. Exp. Res. 26, 582-585

  • Zhang, X.M., Mitchell, D.G., Shi, H., Holland, G.A., Parker, L., Herrine, S.K., Pasqualin, D., and RUBIN, R. (2002) Chronic hepatitis C activity: Correlation with lymphadenopathy on MR Imaging. American Journal of Radiology 179: 417-422

  • Hallak, H., Moehren, G., Tang, J., Kaou, M., Addas, M., Hoek, J.B., RUBIN, R. (2002) Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hepatology 36: 1509-18.

  • Kim, M.-J., Mitchell, D.G., Ito, K., Kim, J.H., Pasqualin, D., and RUBIN, R. (2002) Hepatic iron deposition on magnetic resonance imaging: correlation with inflammatory activity. J. Comp. Assis. Tomog. 26, 988-993

  • Ghiselli, G., Chen, J., Kaou, M., Hallak, H., and RUBIN, R. (2003) Ethanol inhibits fibroblast growth factor-induced proliferation of aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23: 1808-13

  • Hallak, H. and RUBIN, R. (2004) Ethanol Inhibits Palmitoylation of G Protein Gas. J. Neurochem. 89: 919-27

  • RUBIN, R., Harrison, R., Chen, X.-G., Corzitotto, J., Hoek, J.B., and Hallak, H. (2004) Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanol. Biochem. Pharm. 68: 2009-2017

  • Ponnappa, B. Israel, Y., Aini, M. Zhou, F., Russ, R., Cao, Q.-N., Hu, Y. and RUBIN, R. (2005) Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides. Biochem. Pharm. 69: 569-577

  • Brownawell, A.M.,, Berent, S., Brent, R.L., Bruckner, J.V., Doull, J., Gershwin, E.M., Hood, R.D., Matanoski, G.M., RUBIN, R., Weiss, B., and Karol M.H. (2005) The potential adverse health effects of dental amalgam. Toxicol. Rev. 24: 1-10

  • Combes, B., Emerson,S.D., Flye, N., Munoz, S.J&&RUBIN, R., West, A.B., Wheeler, D.E., Contos, M.J., Hofmann, A.F. (2005) Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatmentof primary biliary cirrhosis. Hepatology 42: 1184-1193.

  • Prisco, M. and RUBIN, R. (2007) J. Cell. Physiol. Insulin Receptor Substrate-1 Regulates Murine Embryonic Stem Cell Self-Renewal. In press

  • Mitchell, D.G., Navarro, V., Herrine, S., Bergin, D., Parker, L., Frangos. A, McCue, P., and RUBIN, R. (2007) Compensated Hepatitic C: Grading and Staging by MR. Abdominal Imaging. In press

  • Martin, N., Kim, J., Verma, S., RUBIN, R., Mitchell, D., Bergin, D, and Yeo, C.J. (2007) Intra-abdominal esophageal duplication cysts. J. Gastrointest. Surg. In press

  • BOOKS

  • Editor: Rubins Pathology. RUBIN, R. and Strayer, D. Lipincott, Philadelphia, PA. Fifth edition, March, 2007

  • Fenderson, B and RUBIN, R. Lippincotts Review of Pathology. Lippincott, Philadelphia, PA. 2006

  • Associate Editor: Rubins Pathology. Lippincott, Philadelphia, PA. Fourth edition, 2004

  • Review and analysis of the literature on the health effects of dental amalgem; Life Sciences Research Office; Bethesda, MA 2004 (Co-author)

  • Chapters:

  • Co-author:

  • Liver Pathology: Rubins Pathology. Lipincott, Philadelphia, PA. Fourth and Fifth editions

  • Pancreas Pathology: Rubins Pathology. Lipincott, Philadelphia, PA. Fourth and Fifth editions

  • Endocrine Pathology: Rubins Pathology. Lipincott, Philadelphia, PA. Fourth edition

  • Neoplasia: Pathology. Rubins Pathology, E. ed. Lipincott, Philadelphia, PA. Fourth and Fifth editions

  • Hematopathology. Rubins Pathology. Lipincott, Philadelphia, PA. Fifth edition

Individual Expertise profile of Raphael Rubin, M.D., Copyright © Raphael Rubin, M.D..
Last Updated by Admin : Monday, November 19, 2007 9:10:30 AM



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