Dr. Tliba Omar Tliba , PhD

Contact Dr. Tliba

901 Walnut Street
Suite 919
Philadelphia, PA 19107

(215) 503-7467
(215) 503-9052 fax

Education
Doctor of Veterinary Medicine, First Class Honors, El-Tarf Veterinary School, Annaba, Algeria, 1996

MS, Immunophysiology of infectious diseases, Pasteur Institute, Paris, France, 1999

PhD, Immunology, University of Francois Rebellais, Tours, France, 2001

Fellowship
Postdoctoral fellowship, Pulmonary Division, University of Pennsylvania, Philadelphia, PA, 2002-2005

University Appointment
Associate Professor, Department of Pharmaceutical Sciences, 2008

Professional Organizations
American Society for Pharmacology and Experimental Therapeutics
American Thoracic Society

Research/Clinical Interests
Molecular mechanisms mediating glucocorticoid resistance in chronic inflammatory diseases

Publications

Most recent Peer-reviewed Publications

  1. Cytokines alter glucocorticoid receptor phosphorylation in airway cells: Role of phosphatases
  2. Steroid resistance in severe asthma: Current mechanisms and future treatment
  3. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
  4. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1
  5. Airway smooth muscle as an immunomodulatory cell
  6. Transcriptional regulation of cytokine function in airway smooth muscle cells
  7. Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: Relevance to pulmonary lymphangioleiomyomatosis
  8. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production (Journal of Immunology (2009) 182 (7888-7896))
  9. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production (Journal of Immunology (2009) 182 (7888-7896))
  10. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production
  11. Noncontractile functions of airway smooth muscle cells in asthma
  12. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells
  13. Essential role of IFNβ and CD38 in TNFα-induced airway smooth muscle hyper-responsiveness
  14. Regulation of inflammation by airway smooth muscle
  15. Cytokines induce an early steroid resistance in airway smooth muscle cells: Novel role of interferon regulatory factor-1
  16. Interferon β augments Tuberous Sclerosis Complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
  17. Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
  18. Airway smooth muscle cell as an inflammatory cell: Lessons learned from interferon signaling pathways
  19. Inhibition of tumor necrosis factor-α-inducible inflammatory genes by interferon-γ is associated with altered nuclear factor-κB transactivation and enhanced histone deacetylase activity
  20. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-α and interferon-γ by a mechanism involving the up-regulation of the glucocorticoid receptor β isoform

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