Thomas Jefferson University - Charles J Yeo
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Charles J Yeo
Surgery
Thomas Jefferson University
Jefferson Medical College
Department of Surgery
Samuel D. Gross Professor and Chair of Surgery
Member, Kimmel Cancer Center
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Mailing Address
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1015 Walnut Street, 620 Curtis
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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MD, FACS
Undergraduate: Princeton University, 1975
Medical School: Johns Hopkins University School of Medicine, 1979
Internship: Johns Hopkins Hospital
Residency: Johns Hopkins Hospital
Research Fellowship: S.U.N.Y. Downstate Medical Center, Brooklyn, NY
Board Certification: Surgery
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Expertise and Research Interests
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Dr. Yeo's primary interests and research have been in the fields of hepatopancreaticobiliary surgery - the evaluation of patients with pancreatic and related cancer, and the management of patients with unusual pancreatic neoplasms, as well as acute or chronic pancreatitis.
- Editor-in-chief of the two-volume encyclopedic Shackelford's Surgery of the Alimentary Tract, 6th Edition, published in 2007 Press Release
- Serves on the editorial boards of Langenbeck's Archives of Surgery and Surgery
- Associate Editor of Advances in Surgery and Journal of Gastrointestinal Surgery
- Author of over 375 peer reviewed scientific papers, numerous abstracts, and over 85 book chapters
- Travels nationally and internationally teaching and lecturing on the treatment of benign and malignant pancreatic diseases
- Personally performed over 950 Whipple procedures, and has treated well over 1300 patients with pancreatic and related cancers
Dr. Charles J. Yeo was born in East Orange, NJ, and graduated from high school in Spring Valley, New York. He graduated from Princeton University in 1975, summa cum laude with an A.B. degree in Biochemistry. Dr. Yeo then graduated in 1979 from the Johns Hopkins University School of Medicine, receiving the Upjohn Achievement Award and being elected to Alpha Omega Alpha and Phi Beta Kappa. Upon completing his internship and residency in General Surgery at the Johns Hopkins Hospital, he pursued a Research Fellowship at the S.U.N.Y. Downstate Medical Center in Brooklyn, NY. Dr. Yeo joined the faculty of the Johns Hopkins University as an Instructor and Assistant Chief of Service in the Department of Surgery in 1985, and rose to the rank of Professor in 1996. In 1997, he became a Professor in the Department of Oncology. Dr. Yeo directed the Pancreatic Cancer Interdisciplinary Working Group at Johns Hopkins, and served as the Surgical Clerkship Coordinator and Surgical Curriculum Consultant. In 2001, Dr. Yeo received the Alumni Association Excellence in Teaching Award from the Johns Hopkins University School of Medicine. As of October 1, 2005, Dr. Yeo was named the Samuel D. Gross Professor and assumed the chairmanship of the Department of Surgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia, Pennsylvania.
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Publications
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- Yeo, Charles J., ed. Shackelford's Surgery of the Alimentary Tract. Philadelphia: Saunders, 2007.
- Peer Reviewed Publications (PubMed)
- Selected Publications:
- Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway. Showalter SL, Wang Z, Costantino CL, Witkiewicz AK, Yeo CJ, Brody JR, Carr BI. J Gastroenterol Hepatol. 2009 Nov 19.
- The 'RNA-binding ome': future implications for chemotherapeutic efficacy. Brody JR, Witkiewicz AK, Yeo CJ, Gorospe M, Keen JC. Future Oncol. 2009 Nov;5(9):1317-9.
- Toward improving uniformity and standardization in the reporting of pancreatic anastomoses: A new classification system by the International Study Group of Pancreatic Surgery (ISGPS). Shukla PJ, Barreto SG, Fingerhut A, Bassi C, Büchler MW, Dervenis C, Gouma D, Izbicki JR, Neoptolemos J, Padbury R, Sarr MG, Traverso W, Yeo CJ, Wente MN. Surgery. 2009 Oct 29.
- Changes in operative case experience for general surgery residents: has the 80-hour work week decreased residents' operative experience? Kairys JC, DiMuzio PJ, Crawford AG, Grabo DJ, Yeo CJ. Adv Surg. 2009;43:73-90.
- Reconstruction Following the Pylorus Preserving Whipple Resection: PJ, HJ, and DJ. Kennedy EP, Brumbaugh J, Yeo CJ.J Gastrointest Surg. 2009 Oct 20. [Epub ahead of print]
- Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein-1 in Pancreatic Cancer Cells. Chehl N, Gong Q, Chipitsyna G, Aziz T, Yeo CJ, Arafat HA. J Gastrointest Surg. 2009 Oct 9. [Epub ahead of print]
- Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. Cotton RT, Li D, Scherer SE, Muzny DM, Hodges SE, Catania RL, Witkiewicz AK, Brody JR, Kennedy EP, Yeo CJ, Brunicardi FC, Gibbs RA, Gingras MC, Fisher WE. HPB (Oxford). 2009;11(5):435-44.
- Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. HPB (Oxford). 2009;11(5):373-81.
- Margin Positive Pancreaticoduodenectomy Is Superior to Palliative Bypass in Locally Advanced Pancreatic Ductal Adenocarcinoma. Lavu H, Mascaro AA, Grenda DR, Sauter PK, Leiby BE, Croker SP, Witkiewicz A, Berger AC, Rosato EL, Kennedy EP, Yeo CJ. J Gastrointest Surg. 2009 Sep 16. [Epub ahead of print]
- Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. Surgery. 2009 Aug;146(2):232-40.
- Acinar Cell Carcinoma With a Prominent Intraductal Growth Pattern: Case Report With Review of the Literature. Toll AD, Mitchell D, Yeo CJ, Hruban RH, Witkiewicz AK. Int J Surg Pathol. 2009 Jul 7. [Epub ahead of print]
- Assessment of pancreatic cancer care in the United States based on formally developed quality indicators. Bilimoria KY, Bentrem DJ, Lillemoe KD, Talamonti MS, Ko CY; Pancreatic Cancer Quality Indicator Development Expert Panel, American College of Surgeons. J Natl Cancer Inst. 2009 Jun 16;101(12):848-59. Epub 2009 Jun 9.
- The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Costantino CL, Witkiewicz AK, Kuwano Y, Cozzitorto JA, Kennedy EP, Dasgupta A, Keen JC, Yeo CJ, Gorospe M, Brody JR. Cancer Res. 2009 Jun 1;69(11):4567-72.
- Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. Witkiewicz AK, Costantino CL, Metz R, Muller AJ, Prendergast GC, Yeo CJ, Brody JR. J Am Coll Surg. 2009 May;208(5):781-7; discussion 787-9.
- Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. Berger AC, Howard TJ, Kennedy EP, Sauter PK, Bower-Cherry M, Dutkevitch S, Hyslop T, Schmidt CM, Rosato EL, Lavu H, Nakeeb A, Pitt HA, Lillemoe KD, Yeo CJ. J Am Coll Surg. 2009 May;208(5):738-47; discussion 747-9.
- Assessment of "gene-environment" interaction in cases of familial and sporadic pancreatic cancer. Yeo TP, Hruban RH, Brody J, Brune K, Fitzgerald S, Yeo CJ. J Gastrointest Surg. 2009 Aug;13(8):1487-94. Epub 2009 May 21.
- Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival. Brody JR, Costantino CL, Berger AC, Sato T, Lisanti MP, Yeo CJ, Emmons RV, Witkiewicz AK. Cell Cycle. 2009 Jun 15;8(12):1930-4. Epub 2009 Jun 15.
- Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA. Int J Cancer. 2009 Jul 15;125(2):276-85.
- DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. J Clin Oncol. 2009 Apr 10;27(11):1806-13.
- Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. Brody JR, Costantino CL, Potoczek M, Cozzitorto J, McCue P, Yeo CJ, Hruban RH, Witkiewicz AK. Mod Pathol. 2009 May;22(5):651-9. Epub 2009 Mar 6.
- Impact of obesity on perioperative morbidity and mortality after pancreaticoduodenectomy. Williams TK, Rosato EL, Kennedy EP, Chojnacki KA, Andrel J, Hyslop T, Doria C, Sauter PK, Bloom J, Yeo CJ, Berger AC. J Am Coll Surg. 2009 Feb;208(2):210-7. Epub 2008 Dec 18.
- Implementation of a critical pathway for distal pancreatectomy at an academic institution. Kennedy EP, Grenda TR, Sauter PK, Rosato EL, Chojnacki KA, Rosato FE Jr, Profeta BC, Doria C, Berger AC, Yeo CJ. J Gastrointest Surg. 2009 May;13(5):938-44. Epub 2009 Feb 4.
- Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence. Brody JR, Hucl T, Costantino CL, Eshleman JR, Gallmeier E, Zhu H, van der Heijden MS, Winter JM, Wikiewicz AK, Yeo CJ, Kern SE. Cancer Res. 2009 Feb 1;69(3):984-91. Epub 2009 Jan 20.
- Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Showalter SL, Huang YH, Witkiewicz A, Costantino CL, Yeo CJ, Green JJ, Langer R, Anderson DG, Sawicki JA, Brody JR. Cancer Biol Ther. 2008 Oct;7(10):1584-90. Epub 2008 Oct 3.
- Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome. Witkiewicz AK, Nguyen KH, Dasgupta A, Kennedy EP, Yeo CJ, Lisanti MP, Brody JR. Cell Cycle. 2008 Oct;7(19):3021-5. Epub 2008 Oct 23.
- Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Hostetter C, Licata LA, Witkiewicz A, Costantino CL, Yeo CJ, Brody JR, Keen JC. Cancer Biol Ther. 2008 Sep;7(9):1496-506. Epub 2008 Sep 23.
- Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. Witkiewicz AK, Kennedy EP, Kennyon L, Yeo CJ, Hruban RH. Hum Pathol. 2008 Oct;39(10):1548-51. Epub 2008 Jul 11.
- Does this band make sense? Limits to expression based cancer studies. Williams TK, Yeo CJ, Brody J. Cancer Lett. 2008 Nov 18;271(1):81-4. Epub 2008 Jul 7.
- Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two cases. Duffield AS, Jarrar P, Shum C, Ahuja N, Yeo CJ, Sokoll LJ. Clin Chim Acta. 2008 Sep;395(1-2):166-9. Epub 2008 May 8.
- Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection. Witkiewicz A, Williams TK, Cozzitorto J, Durkan B, Showalter SL, Yeo CJ, Brody JR. J Am Coll Surg. 2008 May;206(5):849-54; discussion 854-6. Epub 2008 Mar 4.
- Cumulative operative experience is decreasing during general surgery residency: a worrisome trend for surgical trainees? Kairys JC, McGuire K, Crawford AG, Yeo CJ. J Am Coll Surg. 2008 May;206(5):804-11; discussion 811-3.
- Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? Showalter SL, Showalter TN, Witkiewicz A, Havens R, Kennedy EP, Hucl T, Kern SE, Yeo CJ, Brody JR. Cancer Biol Ther. 2008 Jul;7(7):986-94. Epub 2008 Apr 21. Review.
- Metastatic disease to the pancreas and spleen. Showalter SL, Hager E, Yeo CJ. Semin Oncol. 2008 Apr;35(2):160-71. Review.
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Individual Expertise profile of
Charles J Yeo, Copyright © Charles J Yeo.
Last Updated
by Administration
: Wednesday, December 30, 2009 4:09:44 PM
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