Thomas Jefferson University - Thomas N. Tulenko, Ph.D.
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Thomas N. Tulenko, Ph.D.
Surgery
Professor and Director
Division of Surgical Research
Departments of Surgery
Biochemistry and Molecular Pharmacology
Thomas Jefferson University
Jefferson Medical College
Member, Kimmel Cancer Center
Appointed
2000
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Mailing Address
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1025 Walnut Street, Suite 605
Philadelphia, Pennsylvania 19107
United States
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Expertise and Research Interests
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Membrane defects in the pathophysiology of human diseases
Atherosclerosis
Cardiovascular Pharmacology
Clinical Lipidology and the treatment of dyslipidemias
Stem cells and regenerative medicine
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Keywords
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Biochemistry; Pathobiology; Vascular Diseases; Vascular Injury; Heart Failure; Smith-Lemli-Opitz Syndrome, stem cells
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Publications
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- Levitan, I., Christian, A., Rothblat, G.R. and Tulenko, T.N Alterations in cell volume regulation in endothelial cells following cholesterol enrichment of the cell membrane. J. Gen Physiol. 115(4): 405-416. 2000.
- Tulenko, T.N, Sumner, A. E. Chen, M., Huang, Y, Ferdinand, F.D. and L. Laury-Kleintop. The Smooth Muscle Cell Membrane During Atherogenesis: A Potential Target For Amlodipine In Atheroprotection. Am. Heart J. 141:1-10. 2001.
- Tulenko, T.N, Sumner, A. E. The Physiology of Lipoproteins. J. Nuc. Cardiol. 9:638-49, 2002
- Mason, R.P. Tulenko, T.N and Jacobs, R.F. Direct evidence for cholesterol crystalline domains in biological membranes: Role in human pathobiology. Biochim. Biophys. Acta 1610:198 207. 2003
- Troup, G.M, Tulenko, T.N, Lee, S.P. and Wrenn, SP. Detection and characterization of laterally phase separated cholesterol domains in model lipid membranes. Colloids and Surfaces B: Biointerfaces 29:217-231. 2003
- Tulenko, T.N Regulating cross talk between vascular smooth muscle cells Arterioscl., Thromb. Vasc. Biol. 23:1707-1709, 2003
- Huang, Y., *Walker, K., Hanely, F., Narula, J., Houser, S.R. and Tulenko, T.N Impaired systolic and diastolic function following a cholesterol-rich diet. Circulation 109:97-102. 2004.
- LaBelle, EF, Tulenko, TN. LDL, IGF-1, and VSMC Apoptosis: Linking Atherogenesis to Plaque Rupture in Vulnerable Lesions. Cardiovasc. Res. 61:204 205, 2004
- Guarino AJ, Tulenko TN, Wrenn SP. Cholesterol crystal nucleation from enzymatically modified low-density lipoproteins: combined effect of sphingomyelinase and cholesterol esterase. Biochemistry. 43(6):1685-93, 2004.
- Troup, G.M. Tulenko, T.N, Lee, S.P. and Wrenn, SP. Estimating the size of laterally phase separated cholesterol domains in model membranes with Förster resonance energy transfer: a simulation study. Colloids and Surfaces B: Biointerface. 2004.
- Capuzzi, D.M., Morgan, J.M., Carey, C.M., Intenzo, C., Tulenko, T.N and Cressman, M.D. Rosuvastatin alone or with extended-release niacin: A new therapeutic option for patients with combined hyperlipidemia. Preventive Cardiology 7(4):176-81, 2004.
- Patrick J. Schaner, Niels D. Martin, Thomas N. Tulenko, Irving M. Shapiro, Nicholas A. Tarola, Rhoda F. Leichter, R. Anthony Carabasi, Paul J. DiMuzio. Decellularized vein as a potential scaffold for vascular tissue engineering. J Vasc Surg 40:146-53, 2004
- Andrew J. Guarino, A.J., Lee, S.P. Tulenko, T.N,and Wrenn, S. Aggregation kinetics of low density lipoproteins upon exposure to sphingomyelinase. J Colloid Interface Sci 279:109-116, 2004
- Kahn, K, Battaglia, K., Huang, Y,, Mason, RP., Stepp, D., Petrov, A., Tulenko, TN, Influence of Serum Cholesterol on Atherogenesis and Intimal Hyperplasia After Angioplasty: Inhibition by Amlodipine. Am J Physiol Heart Circ Physiol. 288:H591-H600, 2005.
- Troup, G., Boesze-Battaglia, K., Huang, Y., Xie, Y., Kirk,, T., Hanley, F., Tulenko, TN. Membrane cholesterol and the formation of cholesterol domains in the pathogenesis of cardiovascular disease. Macromol. Symp. 219: 25-38, 2005
- Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN, Wrenn SP, Narula J. Atherosclerotic plaque progression and vulnerability to rupture: Angiogenesis as a source of intraplaque hemorrhage. Arterioscler. Thromb. Vasc. Biol. 25(10):2054-2061, 2005.
- Tulenko, T,N. Boeze-Battaglia, K., Mason, R. P. Tint, G.S., Steiner, R.D., Connor, W. E. and Labelle, E. F. A membrane defect in the pathogenesis of the Smith-Lemli-Opitz syndrome. J. Lipid Res. 47(1):134-43, 2006Guarino A. J, Tulenko T .N, Wrenn S. P. Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size: biological significance. Chem Phys Lipids. 142(1-2):33-42, 2006.
- DiMuzio P, Tulenko T. Tissue engineering applications to bypass graft development: The use of adipose-derived stem cells. J Vasc Surg. 45:99A-103A, 2007.
- Dimuzio P, Fischer L, McIlhenny S, Dimatteo C, Golesorhki N, Grabo D, Tarola N, Mericli A, Shapiro I, Tulenko T. Development of a tissue engineered bypass graft seeded with stem cells. Vascular. 14 (6): 338-42. 2006.
- Brody JR and Tulenko, TN. No K01 Offered from the NCI: What's the Message? Cancer Biol Ther. 26:7, 2007.
- Fischer L, McIlhenny S, Tulenko T, Golesorkhi N, Zhang P, Larson R, Lombardi J, Shapiro I, DiMuzio P. Endothelial differentiation of adipose-derived stem cells: Effects of endothelial growth supplement and shear force. J Surg Res., 152:157-66, 2009.
- Zhang P, Baxter J, Vinod K, Tulenko TN, Dimuzio P. Endothelial Differentiation of Amniotic Fluid-derived Stem Cells: Synergism of biochemical and shear force stimuli. Stem Cells Dev. 2009 Jun 9. [Epub ahead of print]
- Burd, ID., Ness, A., Berghella, V and Tulenko, T.N Clostridium botulinum toxin A inhibits contractility in pregnant human myometrium in vitro. Reprod Sci. 2009 Jul 14. [Epub ahead of print]
- Harris, L.J., Abdollahi. H., Zhang, P., McIlhenny, S., Tulenko, T.N, DiMuzio, P. Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. (In press).
- McIlhenny, SE, Hager, ES, Grabo, DJ, DiMatteo, C, Shapiro, IM, Tulenko, TN, DiMuzio, PJ. Linear shear conditioning improves vascular graft retention of adipose-derived stem cells by up-regulation of the a5b1 integrin. Tissue Engineering (In press).
- Harris, L.J., Abdollahi. H., Tarola, N.A., DiMatteo, C., McIlhenny, S., Zhang, P., Tulenko, T.N, DiMuzio, P. Isolation of adipose-derived stem cells from patients with vascular disease. (Submitted).
- Abdollahi. H., Harris, L.J., McIlhenny, S., Zhang, P., Ferroni, M., Srinivas, V., Shapiro, I., Tulenko, T.N, DiMuzio, P. The effect of hypoxia on adult stem cell differentiation, function and angiogenesis (Submitted).
- Harris, L.J., Abdollahi. H., Zhang, P., McIlhenny, S., Tulenko, T.N, DiMuzio, P. Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. (Submitted).
- Tulenko, T. N., Ren, G, Kaulin, Y., Steiner, R. D., Connor, W. E., Hanley, F. and Cox, R. H. Altered caveolae and caveolar function in skin fibroblast from patients with the Smith-Lemli-Opitz (SLOS) syndrome. (Submitted).
- Tulenko, T.N Back to Cholesterol: How the molecule contributes to cardiovascular disease. (Submitted)
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Individual Expertise profile of
Thomas N. Tulenko, Ph.D., Copyright © Thomas N. Tulenko, Ph.D..
Last Updated
by Admin
: Thursday, September 24, 2009 1:33:35 PM
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