Each month, Jefferson's acute care program admits approximately 100 patients. The hospital is accredited as a Level I Regional Trauma Center. Two Jeffstat helicopters complement the ambulance fleet for inter-hospital and scene trauma work.

Penetrating injuries make up roughly 20 percent of the cases, providing ample opportunities for residents to learn urgent surgical techniques and resuscitative skills. The majority of patients have blunt injuries that require critical care, consultation with other specialists and management of multisystem failure. In addition, Jefferson is a regional spinal-cord-injury (SCI) center. Each year, it admits many SCI patients, many of whom suffer combined injuries that require stabilization and reconstructive surgery. Jefferson's trauma center has an operating facility and a CAT scan in the emergency department.

Acute Care attendings direct the work of first, second, fourth and fifth-year residents.
Fourth and fifth-year residents respond to all trauma codes as the primary physician,
supervised in surgery by the attending and assisted by junior residents.

Trauma center physicians meet weekly to discuss clinical and system
issues. Jefferson also holds monthly educational conferences for the resident staff.

The Surgical ICU is a separate resident rotation. It is a semi-closed unit with an assigned full time Surgical Attending staff. Formal group rounds are conducted daily. Anesthesia residents and staff complete the pool of available physicians.