Philadelphia University + Thomas Jefferson University

Abraham, David

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David Abraham, PhD

Contact Dr. Abraham

233 South 10th Street
Philadelphia, PA 19107

(215) 503-8917
(215) 923-9248 fax

Research and Clinical Interests

Role of eosinophils, neutrophils and macrophages in innate and adaptive immunity to nematode infections. The goal of these studies is to define at a molecular level the mechanisms used by these cells, from both humans and mice, to kill parasites and to identify the immune evasion mechanisms used by the parasites

Vaccine development against parasitic helminths. Multivalent vaccines are being developed against Onchocerca volvulus, the causative agent of river blindness, and against Stongyloides stercoralis. The basis of the vaccines will the combination of recombinant antigens with adjuvants capable of inducing specific types of immune responses.

Publications

Most Recent Peer-Reviewed Publications

  1. Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice
  2. Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice
  3. Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice
  4. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice
  5. CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: Common ground and distinctions
  6. Activity of azithromycin against Leishmania major in vitro and in vivo
  7. Immunity to Onchocerca spp. in animal hosts
  8. Towards a recombinant antigen vaccine against Onchocerca volvulus
  9. Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice
  10. A novel class of peptides that induce apoptosis and abrogate tumorigenesis in vivo
  11. Chronicity in Strongyloides stercoralis infections: Dichotomy of the protective immune response to infective and autoinfective larvae in a mouse model
  12. Strongyloides stercoralis: Role of antibody and complement in immunity to the third stage larvae in BALB/cByJ mice
  13. Strongyloides stercoralis: Eosinophil-dependent immune-mediated killing of third stage larvae in BALB/cByJ mice
  14. Human T-cell stimulation, molecular characterization and in situ mRNA localization of a Brugia malayi recombinant antigen
  15. Solubilization of epicuticular antigen from Dirofilaria immitis third-stage larvae
  16. Binding of concanavalin A to areas compatible with the locations of the amphids and phasmids of larvae of Dirofilaria immitis (Nematoda: Filarioidea) and Toxocara canis (Nematoda: Ascaridoidea)
  17. Litomosoides carinii in jirds (Meriones unguiculatus): Ability to retard development of challenge larvae can be transferred with cells and serum