Philadelphia University + Thomas Jefferson University

Bray, Paul F.

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Paul F. Bray, MD

Contact Dr. Bray

1015 Walnut Street
Suite 324
Philadelphia, PA 19107

(215) 955-8544
(215) 955-9170 fax

Research and Clinical Interests

Dr. Bray's laboratory studies the role of platelets in cardiovascular disease, and disorders of bleeding and excessive blood clotting. His major areas of investigation include: (1) The role of platelets in arterial thrombosis, with the identification and functional characterization of platelet risk factors and their impact on cardiovascular therapy. He studies how genetic variations in platelet adhesive molecules affect both the clinical and platelet phenotypes. (2) Identification of novel genes and gene products involved in platelet reactivity using genome scan and platelet RNA expression array approaches. (3) Studies on gender differences and hormonal effects on platelet function and thrombosis. (4) Pharmacogenetic studies: a) testing for interactions between candidate genes and hormone therapy using DNA samples from the participants in the Women's Health Initiative, and b) candidate gene and genome-wide scan approaches for determining genes that regulate the platelet response to aspirin.

Publications

Most Recent Peer-Reviewed Publications

  1. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume
  2. Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP
  3. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice
  4. Personalized medicine in thrombosis: Back to the future
  5. Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2
  6. Protease receptor antagonism to target blood platelet therapies
  7. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders
  8. Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
  9. Genome-wide association study of platelet aggregation in African Americans
  10. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs
  11. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
  12. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  13. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  14. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  15. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis
  16. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
  17. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  18. Dengue platelets meet sir arthur conan doyle
  19. MicroRNAs in Platelet Production and Activation
  20. Platelet Genomics