Philadelphia University + Thomas Jefferson University

Paumet, Fabienne

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Fabienne Paumet, PhD

Contact Dr. Paumet

233 South Tenth Street
Bluemle Life Sciences Building Room 750
Philadelphia, PA 19107

(215) 503-8567

Research and Clinical Interests

MOLECULAR MECHANISMS OF PHAGOCYTOSIS: HOW DO PATHOGENS SUBVERT THIS PROCESS?
*Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
*How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?

DO INTRACELLULAR BACTERIA COMMONLY USE SNARE-LIKE PROTEINS TO MANIPULATE THE HOST MEMBRANE FUSION?
*Screening Salmonella and Legionella genomes
*Study the inhibitory effect of potential SNARE-like bacterial proteins

CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
*Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
*Characterization of the specificity of fusion encoded in the SNARE proteins
*Characterization of intramolecular SNARE regulation

STUDY OF THE PHAGOCYTIC MECHANISM IN MAST CELLS, ONE OF THE MAIN PLAYERS IN ALLERGY

Publications

Most Recent Peer-Reviewed Publications

  1. Chlamydia hijacks ARF GTPases to coordinate microtubule posttranslational modifications and golgi complex positioning
  2. Taking control: Reorganization of the host cytoskeleton by Chlamydia
  3. A functional core of IncA is required for Chlamydia trachomatis inclusion fusion
  4. An α-helical core encodes the dual functions of the chlamydial protein IncA
  5. Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells
  6. Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis
  7. Two Coiled-Coil Domains of Chlamydia trachomatis IncA Affect Membrane Fusion Events during Infection
  8. A Novel Function for SNAP29 (Synaptosomal-Associated Protein of 29 kDa) in Mast Cell Phagocytosis
  9. The impact of bacterial infection on mast cell degranulation
  10. SNARE motif: A common motif used by pathogens to manipulate membrane fusion
  11. Intracellular bacteria encode inhibitory SNARE-like proteins
  12. SNARE protein mimicry by an intracellular bacterium
  13. Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
  14. Concerted auto-regulation in yeast endosomal t-SNAREs
  15. The specificity of SNARE-dependent fusion encoded in the SNARE motif
  16. i-SNAREs: Inhibitory SNAREs that fine-tune the specificity of membrane fusion
  17. Cell fusion | La fusion cellulaire
  18. SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line
  19. Mechanisms of membrane fusion | Mécanisme de la fusion membranaire
  20. A t-SNARE of the endocytic pathway must be activated for fusion